ZP-amide A

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ZP-amide A
• 英文别名: 6-hydroxy-N-(2-hydroxy-2-methylpropyl)-11-oxododeca-2,7,9-trienamide
• 化学式: C₁₆H₂₅NO₄
• 分子量: 295.379
• InChiKey: VCRNTFWOWYDPLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ZP-amide A 在 吡啶 、 4-二甲氨基吡啶 作用下， 以 乙醇 、 正己烷 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Isobutylhydroxyamides from Sichuan Pepper and Their Protective Activity on PC12 Cells Damaged by Corticosterone

  摘要：

  The pericarp of Zanthoxylum bungeanum Maxim., commonly known as Sichuan pepper, is a widely used spice to remove fishy odor and add palatable taste. A phytochemical investigation of the 95% ethanol extract of Sichuan pepper resulted in the isolation of 21 isobutylhydroxyamides, induding 8 new ones named ZP-amides G-N, among which the chiral resolution of racemic ZP-amide A and ZP-amide B was successfully accomplished. The protective activity on corticosterone-treated PC12 cells of the isolated isobutylhydroxyamides was also evaluated. The new compounds 3-5 and the known compounds 1, la, 2, 2a, 11, and 15 improved the survival rate of PC12 cells. The bioactivity studies disdosed the potential of Sichuan pepper to be developed as new neuroprotective functional food.

  DOI：

  10.1021/acs.jafc.7b06057