4-fluorodihydrofuran-3(2H)-one | 2769113-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 4-fluorodihydrofuran-3(2H)-one
• 英文别名: 4-fluorooxolan-3-one
• CAS: 2769113-95-1
• 化学式: C₄H₅FO₂
• 分子量: 104.081
• InChiKey: OZNHASPHPVJBCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三甲基氰硅烷 、 4-fluorodihydrofuran-3(2H)-one 、 N-(7-chloro-6-(piperidin-4-yl)isoquinolin-3-yl)-5-oxaspiro[2.4]heptane-1-carboxamide 在 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 N-(7-chloro-6-(1-(3-cyano-4-fluorotetrahydrofuran-3-yl)piperidin-4-yl)isoquinolin-3-yl)-5-oxaspiro[2.4]heptane-1-carboxamide
  参考文献：
  名称：

  [EN] C-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
  [FR] AMIDES ISOQUINOLINE LIÉS À C EN TANT QU'INHIBITEURS DE LRRK2, COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS ASSOCIÉES

  摘要：

  The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

  公开号：

  WO2023055679A1
• 作为产物：
  描述：

  4-fluorotetrahydrofuran-3-ol 在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 4-fluorodihydrofuran-3(2H)-one
  参考文献：
  名称：

  [EN] C-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF
  [FR] AMIDES ISOQUINOLINE LIÉS À C EN TANT QU'INHIBITEURS DE LRRK2, COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS ASSOCIÉES

  摘要：

  The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I): Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

  公开号：

  WO2023055679A1

文献信息

• [EN] N-LINKED ISOQUINOLINE AMIDES AS LRRK2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF<br/>[FR] AMIDES ISOQUINOLINE LIÉS À N EN TANT QU'INHIBITEURS DE LRRK2, COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS ASSOCIÉES
  申请人：MERCK SHARP & DOHME

  公开号：WO2022093881A1

  公开（公告）日：2022-05-05

  The present invention is directed to certain 2-aminoquinzaoline derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, and R3are as defined herein, which are potent inhibitors of LRRK2 kinase and may be useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease and other diseases and disorders described herein. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

  本发明涉及公式（I）的某些2-氨基喹唑啉衍生物及其药学上可接受的盐，其中R1、R2和R3如本文所定义，它们是LRRK2激酶的强效抑制剂，可用于治疗或预防LRRK2激酶参与的疾病，如帕金森病和本文所述的其他疾病和障碍。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗LRRK-2激酶参与的这些疾病中使用这些化合物和组合物。