4-bromo-5-(bromomethyl)-2-chloropyridine | 1471259-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-bromo-5-(bromomethyl)-2-chloropyridine
• CAS: 1471259-55-8
• 化学式: C₆H₄Br₂ClN
• 分子量: 285.365
• InChiKey: PUXHBANZQVIZTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 危险类别：
  8
• 危险性防范说明：
  P264,P270,P271,P280,P303+P361+P353,P304+P340,P305+P351+P338,P310,P330,P331,P363,P403+P233,P501
• 危险品运输编号：
  3261
• 危险性描述：
  H302,H314
• 包装等级：
  II

反应信息

• 作为反应物：
  描述：

  4-bromo-5-(bromomethyl)-2-chloropyridine 在 titanium(IV) tetraethanolate 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 19.0h， 生成 (E)-N-(1-(4-bromo-6-chloropyridin-3-yl)pentan-3-ylidene)-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  [EN] 2,7-NAPHTHYRIDINE COMPOUNDS AS MASTL INHIBITORS
  [FR] COMPOSÉS DE 2,7-NAPHTYRIDINE EN TANT QU'INHIBITEURS DE MASTL

  摘要：

  The invention relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein X and R1to R5are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may inhibit the activities of MASTL receptor and may be useful in the treatment, prevention, suppression and amelioration of cancers, or diseases, disorders and conditions mediated by MASTL receptor.

  公开号：

  WO2024003773A1
• 作为产物：
  描述：

  (4-bromo-6-chloropyridin-3-yl)methanol 在 三溴化磷 作用下， 以 二氯甲烷 为溶剂， 以81 %的产率得到4-bromo-5-(bromomethyl)-2-chloropyridine
  参考文献：
  名称：

  [EN] 2,7-NAPHTHYRIDINE COMPOUNDS AS MASTL INHIBITORS
  [FR] COMPOSÉS DE 2,7-NAPHTYRIDINE EN TANT QU'INHIBITEURS DE MASTL

  摘要：

  The invention relates to compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein X and R1to R5are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds the present invention may inhibit the activities of MASTL receptor and may be useful in the treatment, prevention, suppression and amelioration of cancers, or diseases, disorders and conditions mediated by MASTL receptor.

  公开号：

  WO2024003773A1

文献信息

• THERAPEUTIC COMPOUNDS
  申请人：Gilead Sciences, Inc.

  公开号：US20130281433A1

  公开（公告）日：2013-10-24

  Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

  本文披露的化合物包括公式I′的化合物及其盐。还提供了包含本文披露的化合物的药物组合物、制备本文披露的化合物的方法、用于制备本文披露的化合物的中间体以及使用本文披露的化合物治疗HIV感染的治疗方法。
• Therapeutic compounds
  申请人：Gilead Sciences, Inc.

  公开号：US08987250B2

  公开（公告）日：2015-03-24

  Compounds disclosed herein including compounds of formula I′: and salts thereof are provided. Pharmaceutical compositions comprising compounds disclosed herein, processes for preparing compounds disclosed herein, intermediates useful for preparing compounds disclosed herein and therapeutic methods for treating an HIV infection using compounds disclosed herein are also provided.

  本文提供了包括式I′的化合物及其盐。还提供了含有本文所披露的化合物的药物组合物，制备本文所披露的化合物的方法，用于制备本文所披露的化合物的中间体以及使用本文所披露的化合物治疗HIV感染的治疗方法。
• BENZOTHIAZOL- 6 -YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION
  申请人：Gilead Sciences, Inc.

  公开号：EP2788336A1

  公开（公告）日：2014-10-15
• BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING AN HIV INFECTION
  申请人：Gilead Sciences, Inc.

  公开号：EP2788336B1

  公开（公告）日：2016-03-02
• POLYIMIDE FILM
  申请人：Mortech Corporation

  公开号：US20130280512A1

  公开（公告）日：2013-10-24

  Disclosed herein is a polyimide film having inorganic particles. The polyimide film is 12-250 μm in thickness. The polyimide film includes about 50-90 weight parts of polyimide and about 10-50 weight parts of the inorganic particles. The particle size of each of the inorganic particles is about 0.1 μm to about 5 μm. The polyimide film is characterized in that the thermal expansion coefficient is equal to or less than 30 ppm/° C. in any direction, the difference between two thermal expansion coefficients in two mutually perpendicular directions on the film surface is less than 10 ppm/° C., and the Young's modulus of the polyimide film is greater than 4 GPa in any direction. The dimensional stability of the polyimide film measured by the standard of IPC-TM-650 is less than 0.10% in any direction. A method for manufacturing the polyimide film is disclosed as well.