(R)-N-(pyridyl-2-methyl)-7-diphenylphosphino-7'-amino-1,1'-spiro-dihydro-indene | 1298133-23-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-N-(pyridyl-2-methyl)-7-diphenylphosphino-7'-amino-1,1'-spiro-dihydro-indene
• 英文别名: (3R)-4'-diphenylphosphanyl-N-(pyridin-2-ylmethyl)-3,3'-spirobi[1,2-dihydroindene]-4-amine
• CAS: 1298133-23-9
• 化学式: C₃₅H₃₁N₂P
• 分子量: 510.618
• InChiKey: VLNBBTCWCUGBJR-PGUFJCEWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  38
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吡啶-2-甲醛 、 (R)-7'-(diphenylphosphino)-2,2',3,3'-tetrahydro-1,1'-spirobis[indene]-7-amine 在 三乙酰氧基硼氢化钠 作用下， 以 1,2-二氯乙烷 为溶剂， 以85%的产率得到(R)-N-(pyridyl-2-methyl)-7-diphenylphosphino-7'-amino-1,1'-spiro-dihydro-indene
  参考文献：
  名称：

  另一个配位基团导致酮的不对称加氢极高效的手性铱催化剂

  摘要：

  营业额！带有三齿螺氨基膦配体的高效手性铱催化剂可催化酮的不对称氢化，具有出色的对映选择性（高达99.9％ee）和极高的周转率（TONs；高达455万）。

  DOI：

  10.1002/anie.201102710

文献信息

• CHIRAL SPIRO-PYRIDYLAMIDOPHOSPHINE LIGAND COMPOUND, SYNTHESIS METHOD THEREFOR AND APPLICATION THEREOF
  申请人：Zhou Qilin

  公开号：US20130225822A1

  公开（公告）日：2013-08-29

  The present invention relates to a chiral spiro-pyridylamidophosphine ligand compound, synthesis method therefor and application thereof. The chiral spiro-pyridylamidophosphine compound is a compound having a structure of Formula (I), a racemate or optical isomer thereof, or a catalytically acceptable salt thereof, and is mainly characterized by having a chiral spiro-dihydro-indene skeleton in its structure. The chiral spiro-pyridylamidophosphine compound may be synthesized with optical active 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene or substituted 7-diaryl/alkylphosphino-7′-amino-1,1′-spiro-dihydro-indene having a spiro-skeleton as chiral starting material. The chiral spiro-pyridylamidophosphine compound may be used as a chiral ligand in asymmetric hydrogenation of a carbonyl compound catalyzed by iridium, in which the reaction activity is very high, the amount of the catalyst may be 0.0001 mol %, and the enantioselectivity of the reaction is up to 99.9% ee.
• US8962839B2
  申请人：——

  公开号：US8962839B2

  公开（公告）日：2015-02-24
• An Additional Coordination Group Leads to Extremely Efficient Chiral Iridium Catalysts for Asymmetric Hydrogenation of Ketones
  作者：Jian-Hua Xie、Xiao-Yan Liu、Jian-Bo Xie、Li-Xin Wang、Qi-Lin Zhou

  DOI：10.1002/anie.201102710

  日期：2011.8.1

  What a turnover! An efficient chiral iridium catalyst that bears a tridentate spiro aminophosphine ligand catalyzes the asymmetric hydrogenation of ketones with excellent enantioselectivities (up to 99.9 % ee) and extremely high turnover numbers (TONs; as high as 4 550 000).

  营业额！带有三齿螺氨基膦配体的高效手性铱催化剂可催化酮的不对称氢化，具有出色的对映选择性（高达99.9％ee）和极高的周转率（TONs；高达455万）。