2-(3-Methylpentyl)benzaldehyde | 1268267-81-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Methylpentyl)benzaldehyde
• CAS: 1268267-81-7
• 化学式: C₁₃H₁₈O
• 分子量: 190.285
• InChiKey: HTMNWTOIUHTBPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(3-Methylpentyl)benzaldehyde 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 乙醇 、 1,2-二氯乙烷 为溶剂， 反应 27.0h， 生成 5-((1-ethyl-1-methyl-2,3-dihydro-1H-inden-4-yl)methyl)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
  参考文献：
  名称：

  Expeditious Construction of a Carbobicyclic Skeleton via sp³-C−H Functionalization: Hydride Shift from an Aliphatic Tertiary Position in an Internal Redox Process

  摘要：

  Described herein is the first example of an aliphatic, nonbenzylic hydride shift/cyclization sequence that contains two types of novel sp(3)-C-H functionalization: (1) construction of a tetraline skeleton via [1,5]-hydride shift/cyclization and (2) [1,6]-hydride shift/cyclization to form a five-membered ring (indane derivatives).

  DOI：

  10.1021/ja110520p
• 作为产物：
  描述：

  在 manganese(IV) oxide 、 lithium aluminium tetrahydride 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 18.0h， 生成 2-(3-Methylpentyl)benzaldehyde
  参考文献：
  名称：

  Expeditious Construction of a Carbobicyclic Skeleton via sp³-C−H Functionalization: Hydride Shift from an Aliphatic Tertiary Position in an Internal Redox Process

  摘要：

  Described herein is the first example of an aliphatic, nonbenzylic hydride shift/cyclization sequence that contains two types of novel sp(3)-C-H functionalization: (1) construction of a tetraline skeleton via [1,5]-hydride shift/cyclization and (2) [1,6]-hydride shift/cyclization to form a five-membered ring (indane derivatives).

  DOI：

  10.1021/ja110520p

文献信息

• USE OF PIPERIDINE DERIVATIVES FOR PROMOTING ANGIOGENESIS
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1708705B1

  公开（公告）日：2009-02-18
• PHARMACEUTICAL COMPOSITION FOR PROMOTING ANGIOGENESIS
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP1708705A1

  公开（公告）日：2006-10-11
• Pharmaceutical composition for promoting angiogenesis
  申请人：Hashimoto Ayako

  公开号：US20090187025A1

  公开（公告）日：2009-07-23

  The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R 1 represents a hydrogen atom or a lower alkyl group; and R 2 represents a phenyl lower alkyl group).
• US8445516B2
  申请人：——

  公开号：US8445516B2

  公开（公告）日：2013-05-21
• [EN] PHARMACEUTICAL COMPOSITION FOR PROMOTING ANGIOGENESIS<br/>[FR] COMPOSITION PHARMACEUTIQUE FAVORISANT L'ANGIOGENESE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005072734A1

  公开（公告）日：2005-08-11

  The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R1 represents a hydrogen atom or a lower alkyl group; and R2 represents a phenyl lower alkyl group).