13-D-Hydroxy-docosansaeure | 23559-99-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 13-D-Hydroxy-docosansaeure
• 英文别名: (13R)-13-hydroxydocosanoic acid
• CAS: 23559-99-1
• 化学式: C₂₂H₄₄O₃
• 分子量: 356.59
• InChiKey: BYCZEMFWXYCUSJ-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  25
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 13-D-Hydroxy-docosansaeure 生成 13-hydroxy-docosanoic acid methyl ester
  参考文献：
  名称：

  Absolute configurations of 13-hydroxydocosanoic and 17-hydroxyoctadecanoic acids

  摘要：

  13-D-和13-L-羟基二十二酸甲酯已从9-D-和9-L-羟基十八烷酸合成。将这些酯与由波尔多曲霉产生的13-羟基二十二酸甲酯进行比较，结果显示天然产物具有L-构型。已从由顶芽酵母产生的17-羟基十八烷酸制备了已知的2-D-辛醇，表明该酸也具有L-构型。然而，大多数天然存在的长链羟基酸具有D-构型。

  DOI：

  10.1139/v68-616
• 作为产物：
  描述：

  13-hydroxy-docosanoic acid methyl ester 在 sodium hydroxide 作用下， 生成 13-D-Hydroxy-docosansaeure
  参考文献：
  名称：

  Absolute configurations of 13-hydroxydocosanoic and 17-hydroxyoctadecanoic acids

  摘要：

  13-D-和13-L-羟基二十二酸甲酯已从9-D-和9-L-羟基十八烷酸合成。将这些酯与由波尔多曲霉产生的13-羟基二十二酸甲酯进行比较，结果显示天然产物具有L-构型。已从由顶芽酵母产生的17-羟基十八烷酸制备了已知的2-D-辛醇，表明该酸也具有L-构型。然而，大多数天然存在的长链羟基酸具有D-构型。

  DOI：

  10.1139/v68-616

文献信息

• Nucleic Acids and Proteins and Methods for Making and Using Them
  申请人：Mathur Eric J.

  公开号：US20100011456A1

  公开（公告）日：2010-01-14

  The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs.
• NUCLEIC ACIDS AND PROTEINS AND METHODS FOR MAKING AND USING THEM
  申请人：Chang Hwai

  公开号：US20110296543A1

  公开（公告）日：2011-12-01

  The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs. Polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to a biofuel (e.g., a bioethanol, biomethanol, biopropanol or biobutanol, a biodiesel, etc.), biodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.
• US8119385B2
  申请人：——

  公开号：US8119385B2

  公开（公告）日：2012-02-21
• US8962800B2
  申请人：——

  公开号：US8962800B2

  公开（公告）日：2015-02-24
• [EN] MODIFICATION OF SUGAR METABOLIC PROCESS IN TRANSGENIC CELLS, TISSUES AND ANIMALS<br/>[FR] MODIFICATION D'UN PROCESSUS DE METABOLISME DES GLUCIDES DANS DES CELLULES, DES TISSUS ET CHEZ DES ANIMAUX TRANSGENIQUES
  申请人：UNIV PITTSBURGH

  公开号：WO2005117576A2

  公开（公告）日：2005-12-15

  The present invention provides natural or transgenic galactose deficient cells, tissues, organs and animals that have been genetically modified to compensate for the abnormalities in galactose metabolic pathways. The present invention modifies sugar metabolic pathways to prevent the deleterious accumulation of sugar metabolites in animals, tissues, organs, cells and cell lines that possess natural or transgenic abnormalities in the sugar metabolic pathways. Such cells, tissues, organs and animals can be used in research and medical therapy, including xenotransplantation.