N-octanoylglycinal | 872804-49-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-octanoylglycinal
• 英文别名: N-(2-oxo-ethyl)-octanamide；N-(2-Oxo-aethyl)-octanamid；N-(2-oxoethyl)octanamide
• CAS: 872804-49-4
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.266
• InChiKey: MZEVCHYDXMMNSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-octanoylglycinal 、 2,4-二硝基苯肼 生成 N-[2-(2,4-dinitro-phenylhydrazono)-ethyl]-octanamide
  参考文献：
  名称：

  Brown, Chemistry of Penicillin

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(2,2-dimethoxyethyl)octanamide 生成 N-octanoylglycinal
  参考文献：
  名称：

  N-Acylethanolamines as novel alcohol dehydrogenase 3 substrates

  摘要：

  N-Acylethanolamines (NAEs) are members of the fatty acid amide family. The NAEs have been proposed to serve as metabolic precursors to N-acylglycines (NAGS). The sequential oxidation of the NAEs by an alcohol dehydrogenase and an aldehyde dehydrogenase would yield the N-acylglycinals and/or the NAGs. Alcohol dehydrogenase 3 (ADH3) is one enzyme that might catalyze this reaction. To define a potential role for ADH3 in NAE catabolism, we synthesized a set of NAEs and evaluated these as ADH3 substrates. NAEs were oxidized by ADH3, yielding the N-acylglycinals as the product. The (V/K)(app) values for the NAEs included here were low relative to cinnamyl alcohol. Our data show that the NAEs can serve as alcohol dehydrogenase substrates. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.abb.2010.12.002

文献信息

• [EN] ASPARAGINE DERIVATIVES AND METHODS OF USING SAME<br/>[FR] DÉRIVÉS D'ASPARAGINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：SENDA BIOSCIENCES INC

  公开号：WO2021252640A1

  公开（公告）日：2021-12-16

  The present disclosure relates to compounds of formulas (A) and (I), pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer, such as colorectal cancer, using the same.

  本公开涉及式（A）和（I）的化合物，其药学上可接受的盐，以及任何上述化合物的溶剂化合物，包括相同的药物组合物，制备相同的方法，用于制备相同的中间化合物，以及使用相同的方法治疗或预防疾病，特别是癌症，如结直肠癌。
• Wintersteiner et al., Chemistry of Penicillin
  作者：Wintersteiner et al.

  DOI：——

  日期：——
• MELANIN MODIFICATION COMPOSITIONS AND METHODS OF USE
  申请人：Allergan, Inc.

  公开号：EP2661264A1

  公开（公告）日：2013-11-13
• [EN] MELANIN MODIFICATION COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS DE MODIFICATION DE MÉLANINE ET PROCÉDÉS D'UTILISATION
  申请人：SKINMEDICA INC

  公开号：WO2012094638A1

  公开（公告）日：2012-07-12

  A method for the modification of melanin distribution, and the composition thereof to modify melanin distribution are disclosed. A method for the reduction of melanin distribution, and the composition thereof to reduce melanin distribution are disclosed. A representative composition comprises 4-ethoxybenzaldehyde and one or more additional active agent. s as well as a pharmaceutically acceptable carrier or excipient. Carriers and excipients may be formulated for topical administration. Compositions may also be formaulated for transdermal administration. The compositions may be used for the prevention and treatment of pigmentation disorders, by way of non-limited example, post-inflammatory hyperpigmentation and others. The compositions may be used for lightening skin.