3-methyl-butyric acid N'-acetyl-hydrazide | 82122-72-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-methyl-butyric acid N'-acetyl-hydrazide
• 英文别名: N'-acetyl-3-methylbutanehydrazide
• CAS: 82122-72-3
• 化学式: C₇H₁₄N₂O₂
• 分子量: 158.2
• InChiKey: POOGWLQPEVLNGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methyl-butyric acid N'-acetyl-hydrazide 在 tetraphosphorus decasulfide 作用下， 生成 2-iso-Butyl-5-methyl-1,3,4-thiadiazol
  参考文献：
  名称：

  Lund,H., Acta Chemica Scandinavica (1947), 1973, vol. 27, p. 391 - 395

  摘要：

  DOI：

文献信息

• Composition comprising isovaleramide and ibuprofen
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1576962A1

  公开（公告）日：2005-09-21

  Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and its pharmaceutically acceptable salts, esters, and substituted amides, and other valerian-related compounds, in combination with NSAIDs exhibit clinically significant pharmacological properties which implicate a treatment for acute muscular aches, strains, and sprains which occur from a localized, external insult to a particular muscle or muscle group outside of, or peripheral to, the CNS. The compositions in question generally are non-cytotoxic and do not elicit weakness or sedative activity at doses that are effective for the symptomatic treatment of such pathological conditions.

  缬草的制剂和提取物，以及异戊酰胺、异戊酸及其药学上可接受的盐、酯和取代酰胺，以及其他与缬草有关的化合物，与非甾体抗炎药结合使用，具有显著的临床药理特性，可用于治疗急性肌肉酸痛、拉伤和扭伤，这些症状是由于中枢神经系统以外或外周的特定肌肉或肌肉群受到局部的外部损伤而引起的。这些成分一般不具有细胞毒性，在对症治疗此类病症有效的剂量下，不会引起虚弱或镇静作用。
• Treating a variety of pathological conditions, including spasticity and convulsions, by effecting a modulation of CNS activity with isovaleramide, isovaleric acid, or a related compound
  申请人：NPS PHARMACEUTICALS

  公开号：US20040072900A1

  公开（公告）日：2004-04-15

  Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and certain structurally related compounds exhibit clinically significant pharmacological properties which implicate a treatment for a variety of pathological conditions, including spasticity and convulsions, which are ameliorated by effecting a modulation of CNS activity. The compositions in question generally are non-cytotoxic and do not elicit weakness or sedative activity at doses that are effective for the symptomatic treatment of such pathological conditions.

  缬草制剂和缬草提取物以及异戊酰胺、异戊酸和某些结构相关的化合物具有显著的临床药理特性，可用于治疗各种病症，包括痉挛和抽搐，这些病症可通过调节中枢神经系统的活动而得到改善。这些化合物一般不具有细胞毒性，在有效剂量下不会引起虚弱或镇静作用，可用于此类病症的对症治疗。
• COMPOSITIONS COMPRISING VALERIAN EXTRACTS, ISOVALERIC ACID OR DERIVATIVES THEREOF WITH A NSAID
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1059930A1

  公开（公告）日：2000-12-20
• COMPOSITIONS COMPRISING ISOVALERAMIDE AND IBUPROFEN
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1059930B1

  公开（公告）日：2005-05-11
• TREATMENT OF A VARIETY OF PATHOLOGICAL CONDITIONS, INCLUDING SPASTICITY AND CONVULSIONS, BY EFFECTING MODULATION OF CNS ACTIVITY WITH ISOVALERAMIDE, ISOVALERIC ACID, OR A RELATED COMPOUND
  申请人：NPS PHARMACEUTICALS, INC.

  公开号：EP1176953A2

  公开（公告）日：2002-02-06