water formic acid | 19215-28-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: water formic acid
• 英文别名: formic acid monohydrate；formic acid ; hydrate；Ameisensaeure; Hydrat；formic acid water；formic acid;hydrate
• CAS: 19215-28-2
• 化学式: CH₂O₂*H₂O
• 分子量: 64.041
• InChiKey: HQVFCQRVQFYGRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.12
• 重原子数：
  4
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[1-(1-Imidazolyl)-butyl]-benzonitrile 、 water formic acid 在 镍铝 乙醚 作用下， 反应 1.0h， 以9.1 g of 4-[1-(1-imidazolyl)butyl]-benzaldehyde is obtained的产率得到4-[1-(1-Imidazolyl)butyl]-benzaldehyde
  参考文献：
  名称：

  N-substituted imidazoles and their use in pharmaceutical agents

  摘要：

  本发明涉及N-取代咪唑，其生产过程以及在制药剂中的应用。根据本发明的化合物具有抗芳香化酶的特性。

  公开号：

  US05045558A1
• 作为试剂：
  描述：

  甲酸 、 2-氨基-4-甲基-3,5-二硝基苯甲腈 、 2-Amino-4-methyl-3,5-dinitrobenzonitrile water formic acid 在 铂 水 、 甲酸 、 water formic acid 、 甲醇 作用下， 以 水 为溶剂， 5.0~95.0 ℃ 、1.24 MPa 条件下， 反应 3.25h， 以to obtain 6-(Formylamino)-7-methyl-1H-benzimidazole-4-carbonitrile (9) (6.4 kg, 65% yield)的产率得到D-myo-纤维醇,1-O-(4-甲氧苯基)甲基-2,4,5,6-四-O-(苯基甲基)-,二(苯基甲基)磷酸酯
  参考文献：
  名称：

  Methods of making 6-[(4,5-dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form

  摘要：

  6-[(4,5-二氢-1H-咪唑-2-基)氨基]-7-甲基-1H-苯并咪唑-4-羧腈，基本上不含2,3,7-三氨基-4,6-二甲基-1,9-苯并二氰基的盐酸单乙酰化物，可用于治疗α-2介导的疾病，如眼压增高。

  公开号：

  US20060122248A1

文献信息

• Novel oximes
  申请人：Roussel Uclaf

  公开号：US04420478A1

  公开（公告）日：1983-12-13

  Novel syn isomers of oximes of 3-azidomethyl-7-amino-thiazolyl-cephalosporanic acids of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms, unsaturated alkyl of 2 to 4 carbon atoms, benzoyl and --(CH.sub.2).sub.n --R.sub.1, n is an integer from 1 to 4, R.sub.1 is selected from the group consisting of NH.sub.2 and --COOA' and A' and A are selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, magnesium, --NH.sub.4, an easily cleavable ester group and a non-toxic, pharmaceutically acceptable organic amine and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic activity and a novel process and novel intermediates for their preparation.

  新型合成氧化亚胺的异构体，其化学式为##STR1## 其中R选自氢、1至4个碳原子的烷基、2至4个碳原子的不饱和烷基、苯甲酰和--(CH.sub.2).sub.n --R.sub.1，n为1至4的整数，R.sub.1选自NH.sub.2和--COOA'，A'和A选自氢、碱金属、碱土金属、镁、--NH.sub.4、易于分解的酯基和非毒性、药学上可接受的有机胺及其非毒性、药学上可接受的酸盐，具有抗生素活性，并提供了其制备的新工艺和新中间体。
• Oximes
  申请人：Roussel Uclaf

  公开号：US04439433A1

  公开（公告）日：1984-03-27

  Novel oximes of the syn isomers of 7-[2-(2-amino-4-thiazolyl)-acetamido]ceph-3-eme-4-carboxylic acid compounds of the fomrula ##STR1## wherein B is --(CH.sub.2).sub.n' --R.sub.5, n' is an integer from 1 to 4, R.sub.5 is ##STR2## R.sub.6 and R.sub.7 are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and when taken together with the nitrogen to which they are attached are selected from the group consisting of phthalimido and 1-pyridinyl, R.sub.1 is selected from the group consisting of chloro, CH.sub.3 O--, alkyl and alkylthio of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms, --CH.sub.2 --S--R.sub.12, acetoxymethyl, carbamoyloxymethyl and ##STR3## R.sub.12 is selected from the group consisting of 2-oxo-(3H)-thiazolin-4-yl-carbonyl, 3-methyl-1,2-oxazol-5-yl-carbonyl, acyl of an alkanoic acid of 2 to 4 carbon atoms and a nitrogen heterocycle, Alka is alkyl of 1 to 4 carbon atoms and A is selected from the group consisting of hydrogen, --NH.sub.4, alkali metal, alkaline earth metal, magnesium, a non-toxic, pharmaceutically acceptable organic amine and easily cleaved ester and their non-toxic, pharmaceutically acceptable acid addition salts; having antibacterial activity and novel intermediates therefore.

  化合物的新型氧肟类似物，其为式子##STR1##的7-[2-(2-氨基-4-噻唑基)-乙酰胺基]头孢-3-酰基-4-羧酸化合物的同构体，其中B为--(CH.sub.2).sub.n' --R.sub.5，n'为1到4的整数，R.sub.5为##STR2## R.sub.6和R.sub.7分别选自氢和1到4个碳原子的烷基组成的群，当它们与它们所连接的氮一起被选自邻苯二甲酰亚胺和1-吡啶基的群时，R.sub.1选自氯，CH.sub.3 O--，1到5个碳原子的烷基和烷基硫醚，3到5个碳原子的环烷基，--CH.sub.2 --S--R.sub.12，醋酸甲氧甲基，氨甲酰氧甲基和##STR3## R.sub.12选自2-氧代-(3H)-噻唑烷-4-基-羰基，3-甲基-1,2-噁唑-5-基-羰基，2到4个碳原子的脂肪酸酰基和一个氮杂环，Alka为1到4个碳原子的烷基，A选自氢，--NH.sub.4，碱金属，碱土金属，镁，一种无毒的、药学上可接受的有机胺和容易被水解的酯及其无毒、药学上可接受的酸盐；具有抗菌活性和新型中间体。
• Guanine derivative
  申请人：Astra Lakemedel Aktiebolag

  公开号：US04798833A1

  公开（公告）日：1989-01-17

  Antivirally active compounds of the formula ##STR1## wherein A is ##STR2## wherein m is 1 or 2, n is 1 or 2, whereby m is 1 when n is 2 and m is 2 when n is 1, R.sub.a ' is (CH.sub.2).sub.p OH, NHCONH.sub.2 or COR.sub.a ", R.sub.a " is hydrogen, hydroxy or amino, p is 1 to 4, R.sub.b ' and R.sub.b " are independently selected from hydrogen or (CH.sub.2).sub.p OH, with the proviso that at least one of R.sub.b ' or R.sub.b " is hydrogen; or R.sub.b ' and R.sub.b " together constitute an additional carbon-carbon bond to form an alkyne; or a physiologically acceptable salt, geometric or optical isomer thereof; pharmaceutical preparations containing the compounds and methods for treatment of virus infections.

  该公式的抗病毒活性化合物为：其中A为，m为1或2，n为1或2，当n为2时，m为1，当n为1时，m为2，Ra'为（CH2）p OH，NHCONH2或CORa"，Ra"为氢，羟基或氨基，p为1至4，Rb'和Rb"分别选择氢或（ ）p OH，但至少其中一个为氢；或Rb'和Rb"共同形成另一个碳-碳键以形成炔烃；或其生理上可接受的盐，几何或光学异构体；含有该化合物的制药制剂和治疗病毒感染的方法。
• Process for the production of 2-fluoropurine derivatives
  申请人：Schering Aktiengesellschaft

  公开号：US05696255A1

  公开（公告）日：1997-12-09

  This invention relates to a process for the production of 2-fluoropurine derivatives from 2-aminopurine derivatives, which are reacted in HF/pyridine or HF/pyridine/H.sub.2 O in the presence of a nitrite.

  本发明涉及一种从2-氨基嘌呤衍生物生产2-氟嘌呤衍生物的过程，该过程在HF/吡啶或HF/吡啶/H.sub.2 O存在亚硝酸盐的情况下进行反应。
• ALPHA HELIX MIMETICS IN THE TREATMENT OF CANCER
  申请人：Kouji Hiroyuki

  公开号：US20110263607A1

  公开（公告）日：2011-10-27

  Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a compound relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

  本发明涉及Alpha-螺旋拟态结构和化合物，其由公式（I）表示，其中一般公式和每个符号的定义如规范中所定义，涉及该化合物的一种化合物以及涉及该化合物的方法。还公开了这些化合物在治疗医疗状况（例如癌症疾病、纤维化疾病）中的应用，以及包含这些拟态物质的制药组合物。