N-(35-hydroxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)phthalimide | 1050500-42-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-(35-hydroxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)phthalimide
• 英文别名: 2-(35-Hydroxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)isoindoline-1,3-dione；2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]isoindole-1,3-dione
• CAS: 1050500-42-9
• 化学式: C₃₂H₅₃NO₁₄
• 分子量: 675.771
• InChiKey: QOUVGEIWBFXFEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  47
• 可旋转键数：
  35
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  159
• 氢给体数：
  1
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  N-(35-hydroxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)phthalimide 在 咪唑 、 碘 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 1.5h， 以94.6%的产率得到N-(35-iodo-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)phthalimide
  参考文献：
  名称：

  Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

  摘要：

  We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

  DOI：

  10.1021/ja8041096
• 作为产物：
  描述：

  dodecaethyleneglycol monotosylate 、 potassium phtalimide 以 N,N-二甲基甲酰胺 为溶剂， 以75.6%的产率得到N-(35-hydroxy-3,6,9,12,15,18,21,24,27,30,33-undecaoxapentatriacontyl)phthalimide
  参考文献：
  名称：

  Coupling Across a DNA Helical Turn Yields a Hybrid DNA/Organic Catenane Doubly Tailed with Functional Termini

  摘要：

  We describe the synthesis of a hybrid DNA/organic macrocycle that is prepared by formation of an amide linkage across one full turn of DNA. Formation of a catenane proved that the linkage crossed a turn rather than running along the phosphodiester backbone contour. The product, a doubly tailed catenane, contains 5'- and 3'-termini that can be functionalized further or used to incorporate the catenane structure into other DNA assemblies.

  DOI：

  10.1021/ja8041096

文献信息

• Branched Discrete PEG Constructs
  申请人：Davis Paul D.

  公开号：US20170313656A1

  公开（公告）日：2017-11-02

  Disclosed are general and “substantially pure” branched discrete polyethylene glycol constructs useful in attaching to a variety of biologically active groups, for example, preferential locators, as well as biologics like enzymes, for use in diagnostics, e.g. imaging, therapeutics, theranostics, and moieties specific for other applications. In its simplest intermediate state, a branched discrete polyethylene glycol construct is terminated at one end by a chemically reactive moiety, “A”, a group that is reactive with a biologic material that creates “A”, which is a biologically reactive group, connected through to a branched core (BC) which has attached at least two dPEG-containing chains, indicated by the solid line, , having terminal groups, which can be charged, non-reactive or reactable moieties and containing between about 2 and 64 dPEG residues.