3-ethylthio-1-phenyl-1H-pyrrole-2,5-dione | 32774-52-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 3-ethylthio-1-phenyl-1H-pyrrole-2,5-dione
• 英文别名: 3-Ethylsulfanyl-1-phenylpyrrole-2,5-dione
• CAS: 32774-52-0
• 化学式: C₁₂H₁₁NO₂S
• 分子量: 233.291
• InChiKey: CJTUGRPLMJTGFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  62.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-苯基马来酰亚胺 、 α-Ethylmercapto-acrylsaeure-methylester 以34%的产率得到
  参考文献：
  名称：

  DOPP, DIETRICH;LIBERA, HUBERT;SAMOURIS, KONSTANTINOS, PHOSPH., SULFUR AND SILICON AND RELAT. ELEM., 58-59,(1991) N-4, C. 193-19+

  摘要：

  DOI：

文献信息

• Copper(I) Iodide-Catalyzed Sulfenylation of Maleimides and Related 3-Indolylmaleimides with Thiols
  作者：Zhen-Hua Yang、Yu-Long An、Ying Chen、Zhi-Yu Shao、Sheng-Yin Zhao

  DOI：10.1002/adsc.201600812

  日期：2016.12.7

  An efficient copper(I) iodide‐catalyzed sulfenylation of maleimides and related 3‐indolylmaleimides with thiols has been developed in the presence of fluoroboric acid. Several 3‐thiomaleimides and 3‐indolyl‐4‐thiomaleimides were obtained with good yields under ligand‐free conditions. The methods are simple, practical and show good functional group tolerance.

  在氟硼酸的存在下，已开发出一种高效的碘化铜（I）催化的马来酰亚胺及相关的3-吲哚基马来酰亚胺与硫醇的亚磺酰基化反应。在无配体条件下，以良好的收率获得了一些3-硫代马来酰亚胺和3-吲哚基-4-硫代马来酰亚胺。该方法简单，实用并且显示出良好的官能团耐受性。
• Reversible Covalent Linkage of Functional Molecules
  申请人：Smith Mark

  公开号：US20120190124A1

  公开（公告）日：2012-07-26

  The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R 1 —H which comprises a first functional moiety of formula F 1 to a second functional moiety of formula F 2 wherein X, X′, Y, R 1 , F 1 and F 2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.

  本发明涉及使用含有式（I）部分的化合物作为试剂，将式R1-H的化合物与第一功能基团式F1组成的化合物与第二功能基团式F2连接起来，其中X、X'、Y、R1、F1和F2的定义如本文所述。本发明还提供相关的过程和产品。本发明有用于创建功能共轭化合物，特别是至少有一个组分分子携带巯基的共轭物。
• Functionalisation of Solid Substrates
  申请人：Smith Mark

  公开号：US20120190579A1

  公开（公告）日：2012-07-26

  The present invention relates to a product comprising a solid substrate and a moiety of formula (I) linked thereto: wherein X, X′ and R are as defined herein. The product is useful for immobilising target molecules such as molecules of biochemical interest to solid substrates for numerous applications, such as affinity chromatography, ELISA, biotechnological assay techniques and solid phase peptide synthesis.

  本发明涉及一种包括固体基质和与之连接的式(I)的基团的产品：其中X、X'和R的定义如本文所述。该产品可用于将靶分子（如生化学感兴趣的分子）固定到固体基质上，用于许多应用，例如亲和层析、ELISA、生物技术分析技术和固相肽合成。
• Thiol Protecting Group
  申请人：Smith Mark

  公开号：US20120190814A1

  公开（公告）日：2012-07-26

  The present invention relates to the use of a compound comprising a moiety of formula (I) as a reagent for protecting a thiol group in a thiol compound wherein X, X′ and Y are as defined herein. The protecting group methodology of the present invention allows straightforward and selective protection of thiol groups. Cleaving of the thiol group to regenerate the thiol functional group is also facile and controllable. The present invention further provides an analogous protecting group methodology directed to protection of disulfide groups.

  本发明涉及使用具有式(I)的部分的化合物作为保护巯基化合物中巯基的试剂，其中X、X'和Y如本文所定义。本发明的保护基方法允许直接和选择性地保护巯基。裂解巯基以再生巯基官能团也是容易和可控的。本发明还提供了一种类似的保护基方法，用于保护二硫键基团。
• Doepp, Dietrich; Libera, Hubert; Samouris, Konstantinos, Phosphorus, Sulfur and Silicon and the Related Elements, 1991, vol. 59, # 1-4, p. 193 - 196
  作者：Doepp, Dietrich、Libera, Hubert、Samouris, Konstantinos

  DOI：——

  日期：——