γ-Glutamyl-S-methylcysteinsulfoxid | 19046-23-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: γ-Glutamyl-S-methylcysteinsulfoxid
• 英文别名: gamma-Glutamyl-S-methylcysteine sulfoxide；2-amino-5-[(1-carboxy-2-methylsulfinylethyl)amino]-5-oxopentanoic acid
• CAS: 19046-23-2
• 化学式: C₉H₁₆N₂O₆S
• 分子量: 280.302
• InChiKey: MQEBEBZYRKXMDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  166
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  γ-Glutamyl-S-methylcysteinsulfoxid 、 盐酸 生成 L-谷氨酸
  参考文献：
  名称：

  LARSEN, PEDER OLESEN;SUNDANL, MARIA;SZHUSTORENSEN, FINN TORVEN;WIESZORKOW+, BIOCHEM. SYST. AND ECOL., 15,(1987) N 5, 575-579

  摘要：

  DOI：

文献信息

• Sulfoxyalkyl organonitro and related compounds and pharmaceutical compounds for use in medicine
  申请人：EpicentRx, Inc.

  公开号：US11008287B2

  公开（公告）日：2021-05-18

  The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoimmune disease, infection, or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(3,3-dinitroaze-tidin-1-yl)-2-oxoethyl)sulfinyl)-D-alanine and variants thereof.

  本发明提供了磺氧基烷基有机硝基和相关化合物、含有此类化合物的组合物，以及使用此类化合物和组合物治疗医学疾病（如患者的神经退行性疾病、自身免疫性疾病、感染或癌症）的方法。本文所述的示例性硫氧烷基有机硝基化合物包括((2-(3,3-二硝基氮杂环丁烷-1-基)-2-氧代乙基)亚磺酰基)-D-丙氨酸及其变体。
• SULFOXYALKYL ORGANONITRO AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOUNDS FOR USE IN MEDICINE
  申请人：EpicentRx, Inc.

  公开号：US20200157047A1

  公开（公告）日：2020-05-21

  The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoimmune disease, infection, or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(3,3-dinitroaze-tidin-1-yl)-2-oxoethyl)sulfinyl)-D-alanine and variants thereof.
• [EN] SULFOXYALKYL ORGANONITRO AND RELATED COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USE IN MEDICINE<br/>[FR] SULFOXYALKYLE ORGANONITRO, COMPOSÉS APPARENTÉS ET COMPOSITIONS PHARMACEUTIQUES DESTINÉES À ÊTRE UTILISÉES EN MÉDECINE
  申请人：EPICENTRIX INC

  公开号：WO2018071741A1

  公开（公告）日：2018-04-19

  The invention provides sulfoxyalkyl organonitro and related compounds, compositions containing such compounds, and methods for using such compounds and compositions to treat medical disorders, such as a neurodegenerative disorder, autoimmune disease, infection, or cancer in a patient. Exemplary sulfoxyalkyl organonitro compounds described herein include ((2-(3,3-dinitroazetidin-l-yl)-2-oxoethyl)sulfinyl)-D-alanine and variants thereof.