trifluoromethanesulfonamide morpholinium | 87988-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: trifluoromethanesulfonamide morpholinium
• 英文别名: Morpholine;trifluoromethanesulfonamide
• CAS: 87988-74-7
• 化学式: CH₂F₃NO₂S*C₄H₉NO
• 分子量: 236.215
• InChiKey: WVIKLSVKCLMYKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  89.8
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  三氟甲磺酰胺 、 吗啉 生成 trifluoromethanesulfonamide morpholinium
  参考文献：
  名称：

  KVAM, DONALD C.

  摘要：

  DOI：

文献信息

• N-Perfluoroalkylsulfonylimido derivatives of arenecarboxylic acid amides and their oxidative aza Hofmann rearrangement
  作者：Lev M. Yagupolskii、Irina I. Maletina、Liubov V. Sokolenko、Yurii G. Vlasenko、Sergey A. Buth

  DOI：10.1016/j.jfluchem.2008.03.001

  日期：2008.6

  The analogues of carboxamides in which the sp(2)-hybridized oxygen atom is replaced by more electron-withdrawing groups, =NSO(2)CF(3) and =NSO(2)C(4)F(9), have been synthesized. The resulting N-perfluoroalkylsulfonyl arenecarboxamidines ArC(=NSO(2)R(f))NH(2) (Rf = CF(3), C(4)F(9)) undergo an oxidative Hofmann-type rearrangement to the corresponding carbodiimides ArN=C=NSO(2)R(f) under the action of (diacyloxy-iodo)arenes. Rearrangement of related compounds ArC(=NSO(2)R)NH(2) (R = CH(3), Ph) containing fluorine-free substituents at the sulfonyl group also occurs in similar conditions. It was found that the reactivity of amidines rises with the increasing electron-withdrawing ability of the substituent R. (C) 2008 Elsevier B.V. All rights reserved.