L-3-呋喃丙氨酸

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-3-呋喃丙氨酸
• 英文名称: (2S)-2-azaniumyl-3-(furan-3-yl)propanoate
• 化学式: C7H9NO3
• 分子量: 155.15
• InChiKey: ZAFNLUPTKPOREL-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  76.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2R)-2-formamido-3-(furan-3-yl)propanoic acid 生成 L-3-呋喃丙氨酸
  参考文献：
  名称：

  KRETZSCHMAR, GERHARD;WICKE, HEINRICH;SACHSE, BURKHARD

  摘要：

  DOI：

文献信息

• PAR4 AGONIST PEPTIDES
  申请人：Bristol-Myers Squibb Company

  公开号：US20130289238A1

  公开（公告）日：2013-10-31

  The present invention provides PAR4 agonist peptides. These peptides are useful for developing robust PAR4 receptor assays.

  本发明提供PAR4激动肽。这些肽对于开发强大的PAR4受体测定方法非常有用。
• Nasal pharmaceutical compositions containing a NK-2 antagonist
  申请人：Menarini Ricerche S.p.A.

  公开号：EP1297826A1

  公开（公告）日：2003-04-02

  Pharmaceutical compositions suitable for the nasal administration containing: iii) an NK-2 antagonist or its pharmaceutically acceptable salts iv) a polyacrylic acid and/or its derivatives possibly in combination with other excipients used in the preparation of pharmaceutical composition for nasal administration are described.

  适用于鼻腔给药的药物组合物包含：iii) NK-2拮抗剂或其药用盐iv) 聚丙烯酸和/或其衍生物，可能与其他用于制备鼻腔给药药物组合物的辅料结合使用。
• TEMPLATE-FIXED PEPTIDOMIMETICS WITH CCR10 ANTAGONISTIC ACTIVITY
  申请人：Jung Francoise

  公开号：US20120283168A1

  公开（公告）日：2012-11-08

  Novel template-fixed β-hairpin peptidomimetics of the general formula (I) wherein the single elements T or P are α-amino acid residues connected in either direction which, depending on their positions in the chain, are as defined in the description and the claims, and salts thereof, have the property to antagonize the receptor CCR10. They can be used as medicaments to treat or prevent diseases or conditions in the area of dermatological and cutaneous disorders, inflammation, allergic disorders, respiratory diseases, diseases of the gastro-intestinal tract, ophthalmic diseases, haematology and cancer. These β-hairpin peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  具有以下一般式(I)的小说模板固定β-发夹仿生肽，其中单个元素T或P是α-氨基酸残基，可以连接在任何方向上，具体取决于它们在链中的位置，如描述和索赔中所定义，及其盐，具有拮抗受体CCR10的特性。它们可用作药物，用于治疗或预防皮肤病和皮肤疾病、炎症、过敏性疾病、呼吸道疾病、胃肠道疾病、眼科疾病、血液学和癌症等领域。这些β-发夹仿生肽可以通过基于混合固相和溶液相合成策略的过程制备。
• BETA-HAIRPIN PEPTIDOMIMETICS
  申请人：POLYPHOR AG

  公开号：US20160052971A1

  公开（公告）日：2016-02-25

  Beta-hairpin peptidomimetics of the general formula (I), cyclo[P 1 -p 2 -p 3 -p 4 -p 5 -p 6 -p 7 -p 8 p 9 -p 10 -p 11 -p 12 -T 1 -T 2 ], and pharmaceutically acceptable salts thereof, with P 1 to P 12 , T 1 and T 2 being elements as defined in the description and the claims, have Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli . They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

  一般式（I）的β-发夹肽类似物，其化学式为cyclo[P1-p2-p3-p4-p5-p6-p7-p8p9-p10-p11-p12-T1-T2]及其药用盐，其中P1至P12、T1和T2为描述和索赔中定义的元素，具有抗革兰氏阴性菌活性，例如抑制生长或杀灭肺炎克雷伯氏菌、鲍曼不动杆菌和/或大肠杆菌等微生物。它们可用作药物治疗或预防感染，或用作食品、化妆品、药物或其他营养物质的消毒剂。这些肽类似物可以通过基于混合固相和溶液相合成策略的工艺制造。
• TEMPLATE-FIXED PEPTIDOMIMETICS WITH CXCR7 MODULATING ACTIVITY
  申请人：Gombert Frank Otto

  公开号：US20130225506A1

  公开（公告）日：2013-08-29

  Novel template-fixed β-hairpin peptidomimetics of the general formula (I), wherein the single elements T or P are α-amino acid residues connected from the carbonyl (C═O) point of attachment to the nitrogen (N) of the next element in clockwise direction and wherein said elements, depending on their positions in the chain, are defined in the description and the claims have the property to act on the receptor CXCR7. Thus, these β-hairpin peptidomimetics can be useful in the treatment or prevention of diseases or conditions in the area of dermatological disorders, metabolic diseases, inflammatory diseases, fibrotic diseases, infectious diseases, neurological diseases, cardiovascular diseases, respiratory diseases, gastro-intestinal tract disorders, urological diseases, ophthalmic diseases, stomatological diseases, haematological diseases and cancer; or the mobilisation of stem cells.

  该模板固定的β-折叠肽类似物具有一般式（I），其中单个元素T或P是α-氨基酸残基，从羰基（C═O）连接点连接到顺时针方向下一个元素的氮（N），并且这些元素根据它们在链中的位置在说明书和权利要求中定义，具有作用于CXCR7受体的特性。因此，这些β-折叠肽类似物可用于治疗或预防皮肤疾病、代谢性疾病、炎症性疾病、纤维性疾病、感染性疾病、神经系统疾病、心血管疾病、呼吸系统疾病、胃肠道疾病、泌尿系统疾病、眼科疾病、口腔疾病、血液学疾病和癌症；或干细胞的动员。