Cytidine, N-(6-aminohexyl)-2a(2)-deoxy- | 105409-84-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: Cytidine, N-(6-aminohexyl)-2a(2)-deoxy-
• 英文别名: 4-(6-aminohexylamino)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
• CAS: 105409-84-5
• 化学式: C₁₅H₂₆N₄O₄
• 分子量: 326.39
• InChiKey: OVUKZURUFLDHKA-OUCADQQQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  120
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Cytidine, N-(6-aminohexyl)-2a(2)-deoxy- 、 (+)生物素-N-琥珀酰亚胺基酯 生成 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[6-[[1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]amino]hexyl]pentanamide
  参考文献：
  名称：

  ROGET, ANDRE;TEOULE, ROBERT;BAZIN, HERVE

  摘要：

  DOI：
• 作为产物：
  描述：

  2'-deoxy-4-thiouridine 、 1,6-己二胺 生成 Cytidine, N-(6-aminohexyl)-2a(2)-deoxy-
  参考文献：
  名称：

  ROGET, ANDRE;TEOULE, ROBERT;BAZIN, HERVE

  摘要：

  DOI：

文献信息

• Analytical method for detecting and measuring specifically sequenced nucleic acid
  申请人：IntraCel Corporation

  公开号：EP0245206A1

  公开（公告）日：1987-11-11

  A waveguide coated with single-stranded probe nucleic acids and carrying an internally reflected wave signal is contacted with an analyte solution containing denatured test DNA or RNA and fluorescent marker dye. Analyte nucleic acid with sequences homologous to that of the probe polynucleotide will hybridize therewith with concomitant binding of the fluorescent dye to the resultant duplex structures. Fluorescence resulting from the interaction of the wave signal at the waveguide/analyte interface with the signal generating centers created within the space probed by the evanescent component of the wave signal is detected and provides useful information on said sequences homologous to that of the probe nucleic acids.

  涂有单链探针核酸并携带内部反射波信号的波导与含有变性测试 DNA 或 RNA 和荧光标记染料的分析溶液接触。 与探针多核苷酸序列同源的分析核酸将与之杂交，同时荧光染料将结合到由此产生的双链结构上。 波导/分析溶液界面上的波信号与波信号的蒸发分量探测空间内产生的信号发生中心相互作用而产生的荧光被检测到，并提供有关与探针核酸序列同源的所述序列的有用信息。
• EP1221052A4
  申请人：——

  公开号：EP1221052A4

  公开（公告）日：2005-03-16
• CONJUGATED POLYMER TAG COMPLEXES
  申请人：Leif, Robert C.

  公开号：EP1221052A1

  公开（公告）日：2002-07-10
• [EN] ANALYTICAL METHOD FOR DETECTING AND MEASURING SPECIFICALLY SEQUENCED NUCLEIC ACIDS
  申请人：BATTELLE MEMORIAL INSTITUTE

  公开号：WO1987006956A1

  公开（公告）日：1987-11-19

  (EN) A waveguide coated with single-stranded probe nucleic acids and carrying an internally reflected wave signal is contacted with an analyte solution containing denatured test DNA or RNA and fluorescent marker dye. Analyte nucleic acid with sequences homologous to that of the probe polynucleotide will hybridize therewith with concommitant binding of the fluorescent dye to the resultant duplex structures. Fluorescence resulting from the interaction of the wave signal at the waveguide/analyte interface with the signal generating centers created within the space probed by the evanescent component of the wave signal is detected and provides useful information on said sequences homologous to that of the probe nucleic acids.(FR) Un guide d'onde revêtu d'acides nucléiques sondes à brin unique, et portant un signal d'onde réfléchi intérieurement, est mis en contact avec une solution d'analyte contenant de l'ADN ou de l'ARN d'essai dénaturé et un colorant fluorescent marqueur. L'acide nucléique d'analyte ayant des séquences homologues à celles du polynucléotide sonde se soumettra à une hybridisation avec celui-ci et le colorant fluorescent se liera de manière concomitante aux structures duplex résultantes. Une fluorescence produite par l'interaction du signal d'onde à l'interface guide d'onde/analyte avec les centres générateurs de signaux créés à l'intérieur de l'espace sondé par le composant évanescent du signal d'onde est détectée et fournit des informations utiles sur lesdites séquences homologues à celles des acides nucléiques sondes.
• [EN] CONJUGATED POLYMER TAG COMPLEXES<br/>[FR] COMPLEXES MARQUEURS DE POLYMERES CONJUGUES
  申请人：LEIF ROBERT C

  公开号：WO2001027625A1

  公开（公告）日：2001-04-19

  Processes are described for: (1) the sequential solid phase synthesis of polymers with at least one tag, which can be a light emitting and/or absorbing molecular species (optical-label), a paramagnetic or radioactive label, or a tag that permits the physical separation of particles including cells. When multiple optical-labels are suitably arranged in three-dimensional space, the energy transfer from one moleculars species to another can be maximized and the radiationless loss between members of the same molecular species can be minimized; (2) the coupling of these polymers to biologically active and/or biologically compatible molecules through peripheral pendant substituents having at least one reactive site; and (3) the specific cleavage of the coupled polymer from a solid phase support. The tagged-peptide or polymers produced by these processes and their conjugates with an analyte-binding species, such as a monoclonal antibody or a polynucleotide probe are described. When functionalized europium macrocyclic complexes, as taught in our U.S. patents 5,373,093 and 5,696,240, are bound to polylysine and other peptides, the emitted light increases linearly with the amount of bound macrocyclic complex. Similar linearity will also result for multiple luminescent macrocyclic complexes of other lanthanide ions, such as samarium, terbium, and dysprosium, when they are bound to a polymer or molecule.