2-n-dodecylbenzyl chloride | 93-33-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-n-dodecylbenzyl chloride
• 英文别名: 2-dodecylbenzyl chloride；dodecylbenzyl chloride；o-Dodecylbenzyl chloride；1-(chloromethyl)-2-dodecylbenzene
• CAS: 93-33-4
• 化学式: C₁₉H₃₁Cl
• 分子量: 294.908
• InChiKey: ZSKXYSCQDWAUCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-n-dodecylbenzyl chloride 在 十二烷基三甲基氯化铵 、 sodium hydroxide 作用下， 反应 6.0h， 以99.58%的产率得到2-n-dodecylbenzyl alcohol
  参考文献：
  名称：

  一种碱性水解长链烷基苄卤合成长链烷基苄醇的方法

  摘要：

  一种碱性水解长链烷基苄卤合成长链烷基苄醇的方法，涉及一种水热条件相转移催化碱性水解长链烷基苄卤合成长链烷基苄醇的方法，属于有机化合物合成技术领域。在带有搅拌、温控的水热反应釜中加入长链烷基苄卤、碱溶液和长链烷基相转移催化剂，在不断搅拌下将反应物料加热到100～250℃的水热条件下反应0.5～48小时，反应液冷却后静置分层得长链烷基苄醇。本发明将水热强化原理与相转移催化耦合用于长链烷基苄卤的碱性水解反应，创造了一种高选择性和高产率合成长链烷基苄醇的新方法。

  公开号：

  CN107986941A
• 作为产物：
  描述：

  正十二烷基苯 、 聚合甲醛 、 溶剂黄146 以17%的产率得到
  参考文献：
  名称：

  TAKEZAWA, TUNEO;KUSANO, TOHRU, NIPPON KAGAKU KAJSI,(1989) N, S. 1047-1049

  摘要：

  DOI：

文献信息

• Method for producing organic compounds by substituting halogen atoms
  申请人：MITSUI CHEMICALS, INC.

  公开号：EP1486479A1

  公开（公告）日：2004-12-15

  The invention pertains to a method in which a halogen atom of an organic compound is replaced with a group derived from a nucleophilic agent, at high yield and high efficiency, by the following method which includes a step of reacting the nucleophilic agent with an organic material having a halogen atom bonded to a carbon atom having four σ bonds, more specifically: a method for producing an organic compound having Q, the method including a step of reacting a compound represented by general formula (2) with an organic starting material having at least one halogen atom bonded to a carbon atom having four σ bonds so as to replace the halogen atom in the organic starting material with Q:         MQa     (2) (wherein M represents an alkali metal atom, an alkali earth metal atom, or a rare earth metal atom; Q represents a moiety of an inorganic acid or an active hydrogen compound derived by eliminating a proton, wherein Q is a halogen atom different from the halogen atom in the organic starting material having the halogen atom bonded to the carbon atom having the four σ bonds; and a represents an integer of 1 to 3) in the presence of a compound represented by general formula (1) (wherein Z- represents an anion derived by eliminating a proton from an inorganic acid or an active hydrogen compound; R2 is the same or different; R2 each independently represent a C1-C10 hydrocarbon group or two R2 on the same nitrogen atom may be bonded with each other to form a ring with the nitrogen atom).

  这项发明涉及一种方法，其中有机化合物中的卤素原子被来自亲核试剂的基团取代，且产率高效率高，通过以下方法实现，包括以下步骤：将亲核试剂与具有与碳原子形成四个σ键的卤素原子相结合的有机材料反应的步骤，更具体地说：一种用于生产具有Q的有机化合物的方法，包括以下步骤：将由通式（2）表示的化合物与至少一个卤素原子与碳原子形成四个σ键的有机起始材料反应，以将有机起始材料中的卤素原子替换为Q：         MQa     (2) （其中M代表碱金属原子、碱土金属原子或稀土金属原子；Q代表由消除质子衍生的无机酸或活性氢化合物的基团，其中Q是不同于有机起始材料中卤素原子的卤素原子，该卤素原子与具有四个σ键的碳原子相结合；a表示1到3的整数），在通式（1）表示的化合物的存在下 （其中Z-代表由无机酸或活性氢化合物中消除质子衍生的阴离子；R2相同或不同；R2各自独立地表示C1-C10烃基，或者两个R2在同一氮原子上可能与彼此结合形成与氮原子的环）。
• Thiophenyl Alkanoic acids useful as leukotriene antagonists
  申请人：Smithkline Beckman Corporation

  公开号：US04874792A1

  公开（公告）日：1989-10-17

  This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

  本发明涉及具有苯基和硫代取代基的烷酸化合物，其可用作白三烯拮抗剂，并含有这种化合物的药物组合物。本发明还涉及通过给予上述化合物或组合物的有效量来治疗白三烯在其中是因素的疾病。
• Leukotriene antagonists
  申请人：SmithKline Beckman Corporation

  公开号：US04820719A1

  公开（公告）日：1989-04-11

  This invention relates to alkanoic acid compounds having phenyl and thio substituents which are useful as leukotriene antagonists and pharmaceutical compositions containing such compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

  本发明涉及具有苯基和硫代取代基的烷酸化合物，其作为白三烯拮抗剂使用，并含有这种化合物的药物组合物。本发明还涉及通过给予上述化合物或组合物的有效剂量来治疗白三烯是因素的疾病的方法。
• Ester prodrugs
  申请人：SmithKline Beecham Corporation

  公开号：US04937253A1

  公开（公告）日：1990-06-26

  This invention relates to ester prodrugs for alkanoic acid compounds useful as leukotriene antagonists, and pharmaceutical compositions containing such ester prodrug compounds. This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.

  这项发明涉及酯前药，用于烷酸化合物，可作为白三烯拮抗剂，并且包含这种酯前药化合物的药物组合物。此外，这项发明还涉及通过给予上述化合物或组合物的有效量来治疗白三烯是因素的疾病的方法。
• Surface active polymers
  申请人：Macrochem Corporation

  公开号：EP0335624A2

  公开（公告）日：1989-10-04

  Water-soluble or water-swellable polymers ionic in character and having surface-active properties are provided which are based on a lipophilic monomer, which may be an ionic, nonionic and anionic water-soluble monomer, the latter monomer being further characterized by its homopolymer being soluble in water at a pH in the range of 2 to 14. Other monomers may be present. It is preferred that these be water-soluble. The polymers are prepared generally in the usual manner employed for α,β-­ethylenically unsaturated compounds. The products have a myriad of uses, such as thickeners, water-treating aids, sewage treatment, superabsorbers, etc.

  本发明提供了具有表面活性的离子型水溶性或水溶性聚合物，这些聚合物以亲脂性单体为基础，亲脂性单体可以是离子型、非离子型或阴离子型水溶性单体，阴离子型单体的进一步特征是其均聚物在 pH 值为 2 至 14 的范围内可溶于水。也可以加入其他单体。这些单体最好是水溶性的。聚合物的制备方法通常与 α、β-乙烯基不饱和化合物的制备方法相同。产品用途广泛，如增稠剂、水处理助剂、污水处理、超级吸收剂等。