2-Acetylamino-3-mercapto-N-methyl-propionamide | 7606-77-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-Acetylamino-3-mercapto-N-methyl-propionamide
• 英文别名: 2-acetamido-N-methyl-3-sulfanylpropanamide
• CAS: 7606-77-1
• 化学式: C₆H₁₂N₂O₂S
• 分子量: 176.239
• InChiKey: RAHKYMLIVZZMIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  59.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  二环霉素 、 2-Acetylamino-3-mercapto-N-methyl-propionamide 以4%的产率得到
  参考文献：
  名称：

  ABUZAR, SYED;KOHN, HAROLD, J. AMER. CHEM. SOC., 112,(1990) N, C. 3114-3121

  摘要：

  DOI：

文献信息

• Derivaitves of 4-Or 5-Aminosalicylic Acid
  申请人：Wallace John L.

  公开号：US20080207564A1

  公开（公告）日：2008-08-28

  The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

  本发明提供了4-或5-氨基水杨酸的新衍生物，以及含有这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，用于治疗肠道疾病，如炎症性肠病（IBD）和肠易激综合征（IBS），以及预防/治疗结肠癌。更具体地说，这些衍生物包括通过偶氮键，酯键，酸酐键，硫酯键或酰胺键连接到4-或5-氨基水杨酸分子的硫化氢释放基团。此外，本发明提供了制备这些化合物的方法以及它们用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
• DERIVATIVES OF 4- OR 5-AMINOSALICYLIC ACID
  申请人：Wallace John L.

  公开号：US20090233886A1

  公开（公告）日：2009-09-17

  The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

  本发明提供了4-或5-氨基水杨酸的新衍生物，以及包含这些4-或5-氨基水杨酸衍生物作为活性成分的制药组合物，用于治疗肠道疾病，如炎症性肠病（IBD）和肠易激综合征（IBS），以及预防/治疗结肠癌。更具体地说，这些衍生物包括通过偶氮，酯，酸酐，硫酯或酰胺连接到4-或5-氨基水杨酸分子上的释放硫化氢的基团。此外，本发明提供了一种制备这些化合物的方法以及它们用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
• Derivatives of 4- or 5-aminosalicylic acid
  申请人：Wallace L. John

  公开号：US20070197479A1

  公开（公告）日：2007-08-23

  The present invention provides new derivatives of 4- or 5-aminosalicylic acid, and a pharmaceutical composition containing these derivatives of 4- or 5-aminosalicylic acid as active ingredients, useful for the treatment of intestinal diseases such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and for the prevention/treatment of colon cancer. More particularly, these derivatives comprise a hydrogen sulfide releasing moiety linked via an azo, an ester, an anhydride, a thioester or an amide linkage to a molecule of 4- or 5-aminosalicylic acid. Furthermore, the present invention provides a process for preparing these compounds and their use for treating IBD and IBS and the prevention/treatment of colon cancer.

  本发明提供了4-或5-氨基水杨酸的新衍生物，以及包含这些4-或5-氨基水杨酸衍生物作为活性成分的药物组合物，用于治疗肠道疾病，如炎症性肠病（IBD）和肠易激综合征（IBS），以及预防/治疗结肠癌。更具体地说，这些衍生物包括通过偶氮，酯，酸酐，硫酯或酰胺键连接到4-或5-氨基水杨酸分子上的释放氢硫化物的基团。此外，本发明提供了制备这些化合物的方法以及它们用于治疗IBD和IBS以及预防/治疗结肠癌的用途。
• MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF
  申请人：Honda Tadashi

  公开号：US20130274480A1

  公开（公告）日：2013-10-17

  The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.

  本发明涉及单环氰基烯酮组合物及其在治疗癌症、炎症性疾病和神经退行性疾病等疾病中的应用方法。
• CONTROLLED RELEASE FROM MACROMOLECULAR CONJUGATES
  申请人：Ashley Gary

  公开号：US20130116407A1

  公开（公告）日：2013-05-09

  The invention relates to conjugates of macromolecular carriers and drugs comprising linkers that release the drug or a prodrug through rate-controlled beta-elimination, and methods of making and using the conjugates.

  该发明涉及大分子载体和药物的共轭物，包括通过速率控制的β-消除释放药物或前药的连接剂，以及制备和使用这些共轭物的方法。