2,3,3-trichloro-2,3-difluoro-propionic acid | 122882-38-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,3,3-trichloro-2,3-difluoro-propionic acid
• 英文别名: 2,3,3-Trichlor-2,3-difluor-propionsaeure；2,3,3-Trichloro-2,3-difluoropropanoic acid
• CAS: 122882-38-6
• 化学式: C₃HCl₃F₂O₂
• 分子量: 213.396
• InChiKey: RYISNIJQCCRLKV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3,3-trichloro-2,3-difluoro-propionic acid 生成 trans-α,β-difluoro-β-chloroacrylic acid
  参考文献：
  名称：

  DAPPERHELD, STEFFEN;HEUMULLER, RUDOLF;WILDT, MANFRED

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 potassium permanganate 作用下， 生成 2,3,3-trichloro-2,3-difluoro-propionic acid
  参考文献：
  名称：

  Invasive fungal sinusitis in the acquired immunodeficiency syndrome

  摘要：

  Invasive fungal sinusitis can present as either an indolent or fulminant process that primarily affects immunocompromised individuals. In this article, the clinical characteristics of four cases of invasive fungal sinusitis in patients with AIDS are analyzed and 22 additional previously reported cases in the literature are reviewed. In addition to HIV infection, other variables common to these cases include facial pain or headache out of proportion to clinical or radiographic findings, CD4 lymphocyte count less than 50 cells/mm(3), absolute neutrophil count less than 1,000 cells/mm(3), subtle radiographic evidence suggesting invasion and an indolent clinical course of the invasive infection. The most common pathogen detected was Aspergillus fumigatus. Maintaining a high index of suspicion, critically assessing these clinical findings, and prudently reviewing CT scans may facilitate early diagnosis and prompt intervention in these patients.

  DOI：

  10.1016/s0030-6665(00)80009-2