6-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one | 114149-39-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one
• 英文别名: N-[5-(6-oxo-4,5-dihydro-1H-pyridazin-3-yl)-2,3-dihydro-1H-inden-2-yl]benzenesulfonamide
• CAS: 114149-39-2
• 化学式: C₁₉H₁₉N₃O₃S
• 分子量: 369.444
• InChiKey: NVXSHYUWTOVXDJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  96
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-(2-benzenesulphonamido-indan-5-yl)-4-oxobutyric acid 在 一水合肼 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 6-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one
  参考文献：
  名称：

  Benzenesulphonamidoindanyl compounds, medicaments thereof, and processes

  摘要：

  这项发明涉及具有以下结构式的新苯磺胺基茚基化合物##STR1##其中取代基在此定义中对治疗和预防血栓栓塞疾病、动脉硬化和肿瘤转移具有用处。

  公开号：

  US04820705A1

文献信息

• Benzenesulphonamidoindanyl compounds
  申请人：Dr. Karl Thomae GmbH

  公开号：US04929754A1

  公开（公告）日：1990-05-29

  The invention relates to new benzenesulphonamidoindanyl compounds useful in the treatment and prophylaxis of thromboembolic diseases, arteriosclerosis and tumor metastasis.

  该发明涉及新的苯磺酰胺基印丹基化合物，可用于治疗和预防血栓栓塞性疾病、动脉硬化和肿瘤转移。
• Pyridazinone derivatives and processes for preparing the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0579059A1

  公开（公告）日：1994-01-19

  Disclosed are a pyridazinone compound represented by the formula:    wherein (1) R¹ is a substituted or unsubstituted C₁₋₁₀ alkyl, a C₃₋₆ cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R³ is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl; or R¹ and R³ are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula:    where n is 1 or 2; and D is hydrogen or a halogen; or (2) R¹ is a substituted or unsubstituted C₁₋₁₀ alkyl, a substituted or unsubstituted phenyl, a C₃₋₆ cycloalkyl, a lower alkenyl, a heterocyclic group having N, O or S atom or camphor-10-yl; R³ is hydrogen, a substituted or unsubstituted lower alkyl or a lower alkenyl ; or R¹ and R³ are bonded at terminal ends thereof to form a lower alkylene; and Z is a group represented by the formula:    and R² is hydrogen, a substituted or unsubstituted lower alkyl, an aryl or a lower alkenyl; and -A-B- is an ethylene or vinylene each of which may be substituted by 1 or 2 groups selected from the group consisting of a lower alkyl and phenyl group, or a pharmaceutically acceptable salt thereof, and processes for preparing the same.

  本发明公开了一种由式表示的哒嗪酮化合物： 其中(1)R¹是取代或未取代的C₁₋₁₀烷基、C₃₋₆环烷基、低级烯基、具有N、O或S原子的杂环基团或樟脑-10-基；R³ 是氢、取代或未取代的低级烷基或低级烯基；或 R¹ 和 R³ 在其末端键合形成低级亚烷基；以及 Z 是由式表示的基团： 其中 n 为 1 或 2；且 D 为氢或卤素；或 (2) R¹ 为取代或未取代的 C₁₋₁₀ 烷基、取代或未取代的苯基、C₃₋₆ 环烷基、低级烯基、具有 N、O 或 S 原子的杂环基团或樟脑-10-基；R³ 是氢、取代或未取代的低级烷基或低级烯基；或 R¹ 和 R³ 在其末端键合形成低级亚烷基；以及 Z 是由式表示的基团： R²为氢、取代或未取代的低级烷基、芳基或低级烯基；-A-B-为乙烯基或亚乙烯基，其中每个乙烯基或亚乙烯基可被 1 或 2 个选自低级烷基和苯基的基团取代、 或其药学上可接受的盐，以及制备方法。
• Indane derivative and processes for preparing the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0661273A1

  公开（公告）日：1995-07-05

  Disclosed are an indane compound represented by the formula:    wherein R¹ represents a lower alkyl group, a lower alkenyl group or a substituted or unsubstituted monocyclic aromatic heterocyclic group having nitrogen atom as a hetero atom; R² represents hydrogen atom or a lower alkyl group; and A represents a lower alkylene group, or a pharmaceutically acceptable salt thereof and processes for preparing the same.

  本发明公开了一种由式表示的茚满化合物： 其中，R¹代表低级烷基、低级烯基或取代或未取代的单环芳香杂环基团，其氮原子为杂原子；R²代表氢原子或低级烷基；A代表低级亚烷基、 或其药学上可接受的盐及其制备工艺。
• Indane derivatives, processes for preparing the same and synthetic intermediate of the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0661274A1

  公开（公告）日：1995-07-05

  Disclosed are an indane compound represented by the formula:    wherein R¹ is aryl, lower alkyl, cycloalkyl, halogeno-lower alkyl, lower alkenyl, phenyl-substituted lower alkenyl, monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, lower alkoxy, phenoxy, lower alkylamino, lower alkenylamino, phenylamino, lower alkyl substituted by monocyclic or bicyclic aromatic heterocyclic having N, O or S as a hetero atom, or lower alkenyloxy; R² is H or lower alkyl; X is carbonyl or thiocarbonyl; Alk is single bonding arm or lower alkylene; and the dotted line is presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a synthetic intermediate thereof.

  本发明公开了一种由式表示的茚满化合物： 其中R¹是芳基、低级烷基、环烷基、卤代低级烷基、低级烯基、苯基取代的低级烯基、杂原子为N、O或S的单环或双环芳香杂环基、低级烷氧基、苯氧基、低级烷氨基、低级烯氨基、苯氨基、被杂原子为N、O或S的单环或双环芳香杂环基取代的低级烷基或低级烯氧基；R² 是 H 或低级烷基；X 是羰基或硫代羰基；Alk 是单键臂或低级亚烷基；虚线表示存在或不存在双键、 或其药学上可接受的盐、制备方法及其合成中间体。
• Indane derivatives and processes for preparing the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0661273B1

  公开（公告）日：1999-05-19