(6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-hydroxy-2-methyl-1H-inden-5-yl)acetamide | 101930-89-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-hydroxy-2-methyl-1H-inden-5-yl)acetamide
• 英文别名: 2-(6,7-dichloro-2-cyclopentyl-1-hydroxy-2-methyl-1,3-dihydroinden-5-yl)acetamide
• CAS: 101930-89-6
• 化学式: C₁₇H₂₁Cl₂NO₂
• 分子量: 342.265
• InChiKey: QJRTTXPWZXPDRK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-hydroxy-2-methyl-1H-inden-5-yl)acetamide 、 2-<(6,7-dichloro-2-cyclopentyl-2-methyl-1-oxoindane-5-yl)oxy>acetamide 生成 2-<(6,7-dichloro-2-cyclopentyl-1-hydroxy-2-methylindan-5-yl)oxy>acetamide
  参考文献：
  名称：

  Treatment of gray matter edema with

  摘要：

  本发明涉及一种新型的取代-3-(2,3-二氢-1H-茚-5-基)-4-羟基-1H-吡咯-2,5-二酮及其类似物和盐。这些化合物通过选择不同的合成路线，根据特定的结构、中间体的选择或首选反应序列进行合成。这些化合物可用于治疗和预防由于头部创伤、中风（特别是缺血性中风）、呼吸停止、心脏骤停、Reye综合症、脑血栓形成、脑栓塞、脑出血、脑肿瘤、脑炎髓膜炎、脊髓损伤、脑积水、术后脑损伤创伤、由脑部感染引起的水肿和各种脑震荡等所致的脑损伤和水肿。

  公开号：

  US04596821A1
• 作为产物：
  描述：

  (+)-(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)acetamide 在 sodium borohydrid 作用下， 以 乙醇 为溶剂， 生成 (6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-hydroxy-2-methyl-1H-inden-5-yl)acetamide
  参考文献：
  名称：

  Treatment of gray matter edema with

  摘要：

  本发明涉及一种新型的取代-3-(2,3-二氢-1H-茚-5-基)-4-羟基-1H-吡咯-2,5-二酮及其类似物和盐。这些化合物通过选择不同的合成路线，根据特定的结构、中间体的选择或首选反应序列进行合成。这些化合物可用于治疗和预防由于头部创伤、中风（特别是缺血性中风）、呼吸停止、心脏骤停、Reye综合症、脑血栓形成、脑栓塞、脑出血、脑肿瘤、脑炎髓膜炎、脊髓损伤、脑积水、术后脑损伤创伤、由脑部感染引起的水肿和各种脑震荡等所致的脑损伤和水肿。

  公开号：

  US04596821A1

文献信息

• Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones
  申请人：Merck & Co., Inc.

  公开号：US04680414A1

  公开（公告）日：1987-07-14

  The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

  本发明涉及新型取代-3-(2,3-二氢-1H-茚-5-基)-4-羟基-1H-吡咯-2,5-二酮及其类似物和盐。这些化合物通过选择特定的结构、中间体或首选反应序列的方法进行合成。这些化合物可用于治疗和预防脑部损伤和水肿，如头部创伤、中风（特别是缺血性中风）、呼吸停止、心脏停搏、Reye综合征、脑血栓形成、脑栓塞、脑出血、脑肿瘤、脑炎、脊髓损伤、脑积水、术后脑损伤、由脑部感染引起的水肿和各种脑震荡。
• Use of
  申请人：Merck & Co., Inc.

  公开号：US04605664A1

  公开（公告）日：1986-08-12

  The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

  本发明涉及新型的取代-3-(2,3-二氢-1H-茚-5-基)-4-羟基-1H-吡咯-2,5-二酮，它们的类似物和盐。这些化合物通过根据特定结构、中间体的选择或首选反应序列从多种合成途径中选择的方法合成。这些化合物可用于治疗和预防脑部损伤和由头部创伤、中风（特别是缺血性）、呼吸停止、心脏骤停、Reye综合征、脑血栓形成、脑栓塞、脑出血、脑肿瘤、脑脊髓炎、脊髓损伤、脑积水、术后脑损伤创伤、由脑部感染和各种脑震荡引起的水肿。
• Substituted-3-
  申请人：Merck & Co., Inc.

  公开号：US04634717A1

  公开（公告）日：1987-01-06

  The invention relates to novel substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-1H-pyrrole-2,5-diones, their analogs and their salts. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke (particularly ischemic), arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

  本发明涉及新型取代的3-(2,3-二氢-1H-茚-5-基)-4-羟基-1H-吡咯-2,5-二酮及其类似物和盐。这些化合物通过从多种合成途径中选择的方法合成，具体取决于特定结构、中间体的选择或优选反应顺序。这些化合物可用于治疗和预防由于头部创伤、中风(特别是缺血性中风)、呼吸停止、心脏骤停、Reye综合征、脑血栓形成、脑栓塞、脑出血、脑肿瘤、脑炎、脊髓损伤、脑积水、术后脑损伤创伤、由于脑感染和各种脑震荡引起的水肿。
• Substituted-3-(2,3-dihydro-1H-inden-5-yl)-4-Hydroxy-1H-Pyrrole-2,5-diones, their analogs and their salts
  申请人：Merck & Co., Inc.

  公开号：EP0160891A1

  公开（公告）日：1985-11-13

  The invention relates to novel compounds of the formula: in which R and R' are different entities and wherein A is a bond, -0- or -0-(CH2)q; q is 1 to 5; z is 0 or H and OH; R is cycloalkyl, cycloalkyl-lower alkyl, aryl selected from phenyl, halophenyl, methoxyphenyl, hydroxyphenyl, heterocyclic including thienyl, aralkyl selected from benzyl and phenethyl, lower alkyl, lower alkenyl or lower alkynyl; R' is lower alkyl, lower alkenyl; or lower alkynyl; and X and Y are selected from halo and methyl provided that when A is a bond or when A is -O- and z is H and OH, R is not cycloalkyl or alkyl when R' is lower alkyl and both X and Y are chloro when the compounds are racemic. The compounds are useful for the treatment and prevention of injury to the brain and of edema due to head trauma, stroke, arrested breathing, cardiac arrest, Reye's syndrom, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral tumors, encephalomyelitis, spinal cord injury, hydrocephalus, post-operative brain injury trauma, edema due to cerebral infections and various brain concussions.

  本发明涉及式如下的新型化合物： 其中 R 和 R' 为不同的实体，且 A 是键、-0- 或 -0-(CH2)q q 是 1 至 5 z 是 0 或 H 和 OH； R 是环烷基、环烷基-低级烷基、选自苯基、卤代苯基、甲氧基苯基、羟基苯基的芳基、包括噻吩基在内的杂环基、选自苄基和苯乙基的芳烷基、低级烷基、低级烯基或低级炔基； R' 是低级烷基、低级烯基或低级炔基； X和Y选自卤代和甲基，条件是当A为键或当A为-O-且z为H和OH时，R不是环烷基或当R'为低级烷基时，R不是烷基，且当化合物为外消旋体时，X和Y均为氯代。 这些化合物可用于治疗和预防头部创伤、中风、呼吸停止、心脏骤停、雷氏综合征、脑血栓、脑栓塞、脑出血、脑肿瘤、脑脊髓炎、脊髓损伤、脑积水、脑外伤术后创伤、脑部感染引起的水肿以及各种脑震荡引起的脑部损伤和水肿。
• CRAGOE, EDWARD J. , JR.;WOLTERSDORF, OTTO W. , JR.
  作者：CRAGOE, EDWARD J. , JR.、WOLTERSDORF, OTTO W. , JR.

  DOI：——

  日期：——