1,4-dimethylpyrrolidin-3-amine | 1368129-80-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1,4-dimethylpyrrolidin-3-amine
• CAS: 1368129-80-9
• 化学式: C₆H₁₄N₂
• mdl: MFCD22071631
• 分子量: 114.191
• InChiKey: QWUYUMSIOXRISF-UHFFFAOYSA-N

物化性质

• 沸点：
  126.1±8.0 °C(Predicted)
• 密度：
  0.896±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-methylbenzyl)cyclopropanecarboxylic acid 、 1,4-dimethylpyrrolidin-3-amine 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 N,N-二甲基乙酰胺 、 N,N-二甲基甲酰胺 为溶剂， 以20 %的产率得到N-(1,4-dimethylpyrrolidin-3-yl)-1-(3-methylbenzyl)cyclopropane-1-carboxamide
  参考文献：
  名称：

  WO2023/187677

  摘要：

  公开号：

文献信息

• TRICYCLIC GYRASE INHIBITORS
  申请人：Bensen Daniel

  公开号：US20120238751A1

  公开（公告）日：2012-09-20

  Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

  本文披露了具有式I结构的化合物，以及作为抗菌有效的三环酶抑制剂的药用盐、酯和前药，相关的药物组合物、用途和制备该化合物的方法也在考虑之中。
• [EN] NOVEL COMPOUNDS THAT ARE ERK INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS QUI SONT DES INHIBITEURS D'ERK
  申请人：MERCK SHARP & DOHME

  公开号：WO2013063214A1

  公开（公告）日：2013-05-02

  Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1).

  公开的是具有式(1)的ERK抑制剂及其药学上可接受的盐。还公开了使用式(1)的化合物治疗癌症的方法。
• [EN] SUBSTITUTED PYRROLIDINE COMPOUNDS<br/>[FR] COMPOSÉS PYRROLIDINES SUBSTITUÉS
  申请人：EPIZYME INC

  公开号：WO2016040504A1

  公开（公告）日：2016-03-17

  The present disclosure provides substituted pyrrolidine compounds having Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, B, X, and Z are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.

  本公开提供具有以下化学式（I）的取代吡咯烷化合物及其药学上可接受的盐和溶剂化合物，其中R1、B、X和Z如规范中所述。本公开还涉及使用化合物（I）治疗对SMYD蛋白质（如SMYD3或SMYD2）阻断响应的疾病。本公开的化合物特别适用于治疗癌症。
• METHOD FOR PRODUCING QUINOLONE CARBOXYLIC ACID DERIVATIVE
  申请人：SATO Koji

  公开号：US20100063279A1

  公开（公告）日：2010-03-11

  The present invention relates to a method for producing a quinolone compound having high antibacterial activity and high safety, at high yield and in a simple manner. A quinolonecarboxylic acid derivative (1) of interest is produced through a one-pot manner by reacting a compound (2) with a salt of a cyclic amine (3) and with a boron derivative in a solvent in the presence of a base.

  本发明涉及一种制备具有高抗菌活性和高安全性的喹诺酮化合物的方法，其产率高且简单。 通过在溶剂中在碱的存在下将化合物（2）与环状胺（3）的盐和硼衍生物反应，通过一锅法制备所需的喹诺酮羧酸衍生物（1）。
• Method for Production of Quinolone-Containing Lyophilized Preparation
  申请人：Nishimoto Norihiro

  公开号：US20080300403A1

  公开（公告）日：2008-12-04

  The present invention is directed to a lyophilized preparation which contains a synthetic quinolone antibacterial compound and, as a solo additive, a pH-adjusting agent, and which exhibits an excellent reconstituting property. The invention provides a method for producing a lyophilized preparation containing a synthetic quinolone antibacterial compound as an active ingredient, characterized by including, sequentially, cooling an aqueous solution containing a synthetic quinolone antibacterial compound and a pH-adjusting agent to yield a frozen product, elevating the temperature of the frozen product, and re-cooling the resultant to prepare the lyophilized preparation.

  本发明涉及一种冻干制剂，其包含合成喹诺酮类抗菌化合物和一个pH调节剂作为单一添加剂，并表现出优异的重构性能。本发明提供了一种制备含有合成喹诺酮类抗菌化合物作为活性成分的冻干制剂的方法，其特征在于依次包括将含有合成喹诺酮类抗菌化合物和pH调节剂的水溶液冷却以产生冻结产物，提高冻结产物的温度，然后再次冷却以制备冻干制剂。