1,5-di-O-acetyl-1-deuterio-2,3,4,6-tetra-O-methyl-D-glucitol | 64726-62-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,5-di-O-acetyl-1-deuterio-2,3,4,6-tetra-O-methyl-D-glucitol
• 英文别名: 1,5-di-O-acetyl-(1-deuterio)-2,3,4,6-tetra-O-methylglucitol；[(2S,3R,4R,5R)-5-acetyloxy-1-deuterio-2,3,4,6-tetramethoxyhexyl] acetate
• CAS: 64726-62-1
• 化学式: C₁₄H₂₆O₈
• 分子量: 323.348
• InChiKey: OVCJDQPBVXUBBF-NDNBGFGISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (2R,3S,4R,6R)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol 生成 1,5-di-O-acetyl-1-deuterio-2,3,4,6-tetra-O-methyl-D-glucitol
  参考文献：
  名称：

  DOARES, STEVEN H.;ALBERSHEIM, PETER;DARVILL, ALAN G., CARBOHYDR. RES., 210,(1991) C. 311-317

  摘要：

  DOI：

文献信息

• Structural Characterization of Cranberry Arabinoxyloglucan Oligosaccharides
  作者：Kimberly M. Auker、Christina M. Coleman、Mei Wang、Bharathi Avula、Susanna L. Bonnet、Lindsey L. Kimble、Bridget D. Mathison、Boon P. Chew、Daneel Ferreira

  DOI：10.1021/acs.jnatprod.8b01044

  日期：2019.3.22

  indicate that arabinoxyloglucan oligosaccharides are present in cranberry products and may contribute to the antiadhesion properties of urine produced after cranberry consumption, but relatively little is known regarding the oligosaccharide components of cranberry. This report describes the isolation from two cranberry sources and the complete structure elucidation of two arabinoxyloglucan oligosaccharides

  蔓越莓（Vaccinium macrocarpon）产品可在北美食品，果汁和膳食补充剂市场中广泛使用。蔓越莓的使用已广泛用于预防尿路感染（UTI）和其他已报道的健康益处。我们研究小组的初步发现表明，蔓越莓产品中存在阿拉伯糖基葡聚糖低聚糖，可能有助于食用蔓越莓后产生的尿液的抗粘连特性，但对蔓越莓的低聚糖成分知之甚少。该报告描述了从两种蔓越莓来源的分离，以及通过使用碳水化合物特异性NMR光谱法和化学衍生化方法对两种阿拉伯糖基葡聚糖低聚糖的完整结构阐明。这些化合物被鉴定为七糖β-d-吡喃葡萄糖基-（1→4）-[α-d-吡喃吡喃糖基-（1→6）]-β-d-吡喃葡萄糖基-（1→4）-β-d-吡喃葡萄糖基-（1→4）-[α-1-阿拉伯呋喃糖基-（1→2）-α-d-吡喃吡喃糖基-（1→6）]-β-d-吡喃葡萄糖（1）和八糖β-d-吡喃葡萄糖基- （1→4）-[α-1-阿拉伯呋喃糖基-（1→2）-α-d-
• Haemophilus influenzae lipopolysaccharide inner-core oligosaccharide epitopes as vaccines for the prevention of haemophilus influenzae infections
  申请人：Richards C James

  公开号：US20050153057A1

  公开（公告）日：2005-07-14

  The present invention relates to a lipopolysaccharide moiety comprising a conserved triheptosyl inner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extension, and to vaccines obtaines therefrom which are cross-reactive for Haemophilus influenzae strains. The invention also relates to defined mutations in the biosynthetic machinery for lipopolysaccharide (LPS;) expression in Haemophilus influenzae useful to obtain the abovementioned moiety. The invention also relates to using conjugates of the LPS from the mutant strains so obtained to elicit a heterologous immune response against a wide range of disease-causing H. influenzae strains. More specifically, the invention relates to vaccines for prevention of bacterial infections comprising core lipopolysaccharide of Haemophilus influenzae . A lipopolysaccharide moiety comprising a conserved triheptosylinner-core moiety of lipopolysaccharide substantially free of variable outer core oligosaccharide chain extensions.

  本发明涉及一种脂多糖分子，该分子由基本不含可变外核寡糖链延伸的脂多糖保守三庚糖基内核分子组成，并涉及由此获得的疫苗，该疫苗对以下细菌具有交叉反应性 流感嗜血杆菌 菌株产生交叉反应的疫苗。本发明还涉及在流感嗜血杆菌中表达脂多糖（LPS）的生物合成机制中定义的突变。 流感嗜血杆菌 以获得上述分子。本发明还涉及使用从如此获得的突变菌株中提取的 LPS 的共轭物来引起针对多种致病流感嗜血杆菌的异源免疫反应。 流感嗜血杆菌 菌株的异源免疫反应。更具体地说，本发明涉及用于预防细菌感染的疫苗，该疫苗包含流感嗜血杆菌的核心脂多糖。 流感嗜血杆菌 .一种脂多糖分子，包括基本不含可变外核寡糖链延伸的脂多糖保守三链烷基内核分子。
• YORK, WILLIAM S.;KIEFER, LAURA L.;ALBERSHEIM, PETER;DARVILL, ALAN G., CARBOHYDR. RES., 208,(1990) C. 175-182
  作者：YORK, WILLIAM S.、KIEFER, LAURA L.、ALBERSHEIM, PETER、DARVILL, ALAN G.

  DOI：——

  日期：——
• Characterization of the lipopolysaccharide O-antigen of Cronobacter turicensis HPB3287 as a polysaccharide containing a 5,7-diacetamido-3,5,7,9-tetradeoxy-d-glycero-d-galacto-non-2-ulosonic acid (legionaminic acid) residue
  作者：Leann L. MacLean、Evgeny Vinogradov、Franco Pagotto、Malcolm B. Perry

  DOI：10.1016/j.carres.2011.09.003

  日期：2011.11

  Cronobacter turicensis, previously known as Enterobacter sakazakii, is a Gram-negative opportunistic foodborne pathogen that has been reported as a cause of life-threatening neonatal infections. From chemical and physical analyses involving composition analysis, methylation, two-dimensional high-resolution nuclear magnetic resonance, and mass spectrometry methods, the antigenic 0-polysaccharide in the smooth-type lipopolysaccharide of C. turicensis (strain HPB 3287) was determined to be a high molecular mass polymer of a repeating pentasaccharide unit composed of D-galactose, D-glucose, 2-acetamido-2-deoxy-D-galactose, and 5,7-diacetamido-3,5,7,9-tetradeoxy-D-glycero-D-galacto-non-2-ulosonic acid (leg-ionaminic acid), in a molar ratio 2:1:1:1, and having the structure:alpha-D-Glcp1down arrow4[-> 3)-beta-D-Galp-(1 -> 3)-beta-D-GalpNAc-(1 -> 4)-alpha-D-Galp-(1 -> 4)-alpha-Leg5Ac7Ac-(2 ->](0). (C) 2011 Elsevier Ltd. All rights reserved.
• HAEMOPHILUS INFLUENZAE LIPOPOLYSACCHARIDE INNER-CORE OLIGOSACCHARIDE EPITOPES AS VACCINES FOR THE PREVENTION OF HAEMOPHILUS INFLUENZAE INFECTIONS
  申请人：Aventis Pasteur Limited

  公开号：EP1313771B1

  公开（公告）日：2007-03-21