Dimethyl 3-methylidenepentanedioate | 101567-38-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Dimethyl 3-methylidenepentanedioate
• CAS: 101567-38-8
• 化学式: C₈H₁₂O₄
• 分子量: 172.18
• InChiKey: KLYCSEKGIVPKSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Dimethyl 3-methylidenepentanedioate 、 苯甲酰乙酸甲酯 以65%的产率得到
  参考文献：
  名称：

  HUANG, YUJIN;LU, XIYAN, TETRAHEDRON LETT., 28,(1987) N 49, 6219-6220

  摘要：

  DOI：
• 作为产物：
  描述：

  dimethyl 3-acetyloxy-3-methylpentanedioate 、 对甲苯磺酸一水合物 生成 Dimethyl 3-methylidenepentanedioate
  参考文献：
  名称：

  SARGSYAN, M. S.;MKRTUMYAN, S. A.;GEVORKYAN, A. A., ARM. XIM. ZH., 1985, 38, N 9, 577-582

  摘要：

  DOI：

文献信息

• HUANG, YUJIN;LU, XIYAN, TETRAHEDRON LETT., 28,(1987) N 49, 6219-6220
  作者：HUANG, YUJIN、LU, XIYAN

  DOI：——

  日期：——
• Dendritic Polymers With Enhanced Amplification and Interior Functionality
  申请人：Tomalia A. Donald

  公开号：US20070298006A1

  公开（公告）日：2007-12-27

  Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
• US4670163A
  申请人：——

  公开号：US4670163A

  公开（公告）日：1987-06-02
• US7985424B2
  申请人：——

  公开号：US7985424B2

  公开（公告）日：2011-07-26
• [EN] N-SULFONAMIDO POLYCYCLIC PYRAZOLYL COMPOUNDS<br/>[FR] COMPOSÉS N-SULFONAMIDO PYRAZOLYLES POLYCYCLIQUES
  申请人：ELAN PHARM INC

  公开号：WO2010028213A2

  公开（公告）日：2010-03-11

  The current invention provides compounds having a structure according to Formulae (1), (2), (3), and (4): wherein the A-ring, B-ring, C-ring, m, n, R25, R50, and R51 are as described in the specification. The invention also provides pharmaceutical compositions comprising compounds of Formulae (1), (2), (3), and (4), as well as methods of treating cognitive disorders, such as Alzheimer's disease. The invention further provides intermediates useful in preparing the compounds of Formulae (1), (2), (3), and (4).