4-羟基-alpha1-[[[6-(2-苯基乙氧基)己基]氨基]甲基]-1,3-苯二甲醇 | 94749-02-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-羟基-alpha1-[[[6-(2-苯基乙氧基)己基]氨基]甲基]-1,3-苯二甲醇
• 中文别名: 沙美特罗杂质B
• 英文名称: Des(phenylbutoxy)phenylethoxy salmeterol
• 英文别名: 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(2-phenylethoxy)hexylamino]ethyl]phenol
• CAS: 94749-02-7
• 化学式: C₂₃H₃₃NO₄
• 分子量: 387.5
• InChiKey: SFLNGSUKAXWYTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  28
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  82
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1,3-苯二甲醇, ALPHA1-(氨基甲基)-4-羟基- 、 (2-((6-bromohexyl)oxy)ethyl)benzene 生成 4-羟基-alpha1-[[[6-(2-苯基乙氧基)己基]氨基]甲基]-1,3-苯二甲醇
  参考文献：
  名称：

  SKIDMORE, IAN FREDERICK;LUNTS, LAWRENCE HENRY CHARLES;FINCH, HARRY;NAYLOR+

  摘要：

  DOI：

文献信息

• Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
  申请人：Robinson B. Cynthia

  公开号：US20050026884A1

  公开（公告）日：2005-02-03

  A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a β2-agonist bronchodilator for the treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or any other respiratory disease.

  一种药物或兽药组合物，包含选自脱氢表雄酮和/或硫酸脱氢表雄酮或其盐的第一种活性剂，以及包含β2-激动剂支气管扩张剂的第二种活性剂，用于治疗哮喘、慢性阻塞性肺病或任何其他呼吸道疾病。该组合物以各种配方和试剂盒的形式提供。本专利的产品适用于哮喘、慢性阻塞性肺病或任何其他呼吸道疾病的预防和治疗。
• SKIDMORE, IAN FREDERICK;LUNTS, LAWRENCE HENRY CHARLES;FINCH, HARRY;NAYLOR+
  作者：SKIDMORE, IAN FREDERICK、LUNTS, LAWRENCE HENRY CHARLES、FINCH, HARRY、NAYLOR+

  DOI：——

  日期：——
• SKIDMORE, I. F.;LUNTS, L. H. C.;FINCH, H.;NAYLOR, A.
  作者：SKIDMORE, I. F.、LUNTS, L. H. C.、FINCH, H.、NAYLOR, A.

  DOI：——

  日期：——
• ——
  作者：SKIDMORE I. F.、 LUNTS L. H. C.、 FINCH H.、 NAYLOR A.

  DOI：——

  日期：——
• COMBINATION OF DEHYDROEPIANDROSTERONE OR DEHYDROEPIANDROSTERONE-SULFATE WITH A BETA-AGONIST BRONCHODILATOR FOR TREATMENT OF ASTHMA OR CHRONIC OBSTRUCTIVE PULMONARY DISEASE
  申请人：Robinson Cynthia B.

  公开号：US20090285900A1

  公开（公告）日：2009-11-19

  A pharmaceutical or veterinary composition, comprises a first active agent selected from a dehydroepiandrosterone and/or dehydroepiandrosterone-sulfate, or a salt thereof, and a second active agent comprising a β2-agonist bronchodilator for the treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases. The composition is provided in various formulations and in the form of a kit. The products of this patent are applied to the prophylaxis and treatment of asthma, chronic obstructive pulmonary disease, or other respiratory diseases.