5-Nitro-2,2-diphenyl-benzo[1,3]dioxole | 88145-35-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Nitro-2,2-diphenyl-benzo[1,3]dioxole
• 英文别名: 5-Nitro-2,2-diphenyl-2H-1,3-benzodioxole；5-nitro-2,2-diphenyl-1,3-benzodioxole
• CAS: 88145-35-1
• 化学式: C₁₉H₁₃NO₄
• 分子量: 319.317
• InChiKey: GYHXZMMEEKPSTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  64.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-Nitro-2,2-diphenyl-benzo[1,3]dioxole 在 镍 氢气 作用下， 以 乙醇 为溶剂， 以85%的产率得到2,2-diphenyl-benzo[1,3]dioxol-5-amine
  参考文献：
  名称：

  Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity

  摘要：

  A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-l-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.03.005
• 作为产物：
  描述：

  4-硝基儿茶酚 、 二氯二苯甲烷 以61%的产率得到
  参考文献：
  名称：

  HOUWING, H. A.;OENE, J. C.;HORN, A. S., PHARM. WEEKBL. SCI. ED., 1983, 5, N 4, 177-181

  摘要：

  DOI：

文献信息

• Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity
  作者：Christophe Bénard、Fatima Zouhiri、Marie Normand-Bayle、Michèle Danet、Didier Desmaële、Hervé Leh、Jean-François Mouscadet、Gladys Mbemba、Claire-Marie Thomas、Sabine Bonnenfant、Marc Le Bret、Jean d'Angelo

  DOI：10.1016/j.bmcl.2004.03.005

  日期：2004.5

  A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-l-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments. (C) 2004 Elsevier Ltd. All rights reserved.
• HOUWING, H. A.;OENE, J. C.;HORN, A. S., PHARM. WEEKBL. SCI. ED., 1983, 5, N 4, 177-181
  作者：HOUWING, H. A.、OENE, J. C.、HORN, A. S.

  DOI：——

  日期：——