5.5-Dimethyl-1.4.5.6-tetrahydropyrimidin-2-yl-hydrazin | 73960-02-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5.5-Dimethyl-1.4.5.6-tetrahydropyrimidin-2-yl-hydrazin
• 英文别名: 5,5-dimethyl-tetrahydro-pyrimidin-2-one hydrazone；5,5-dimethyl-2-hydrazino-1,4,5,6-tetrahydro-pyrimidine；(5,5-dimethyl-4,6-dihydro-1H-pyrimidin-2-yl)hydrazine
• CAS: 73960-02-8
• 化学式: C₆H₁₄N₄
• mdl: MFCD19216622
• 分子量: 142.204
• InChiKey: VLQKZIWFCOHEHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  225.1±23.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  62.4
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5.5-Dimethyl-1.4.5.6-tetrahydropyrimidin-2-yl-hydrazin 、 反式,反式-1,5-双[4-(三氟甲基)苯基]-1,4-戊二烯-3-酮 生成 Hydramethylnon
  参考文献：
  名称：

  LOVELL, J. B.

  摘要：

  DOI：

文献信息

• Substituted 9,10-anthracene-bis hydrazones and pharmaceutical compositions containing same
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0018850A1

  公开（公告）日：1980-11-12

  There are disclosed anthracene-9,10- bis- carbonyl- lydrazones and derivatives thereof useful for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers. The compounds can be represented by the formula: wherein Z is a trivalent moiety selected from the group consisting of those of the formulae: wherein n is 0, 1, 2 or 3 and R is hydrogen, lower alkyl, cycloalkyl, phenyl or benzyl; R1 is of hydrogen or lower alkyl; R2 is selected from the group consisting of monovalent moieties of the formulae: wherein p is 1, 2 or 3, q is 0, 1 or 2, R' is hydrogen or lower alkyl, R" is lower alkyl R7 is a moiety of the formula: wherein m is 2, 3, 4 or 5, R1, R' and R" are as hereinbefore defined and the moiety -NR'R" may be pyrrolidino, piperidino, morpholino or N-methylpiperazino, X isoxo (O=), thioxo (S=) or imino (R'-N=) wherein R' is as hereinbefore defined), and R3, R4, R5 and R6 are each individually selected from the group consisting of hydrogen, halogen, hydroxy, nitro, amino, sulfonamido, lower alkyl; and the pharmacologically acceptable acid-addition and quaternary ammonium salts thereof. These compunds can be prepared by reaction of 9,10- anthracenedialdehyde with a hydrazine. The dialdehyde is obtained from the reaction of anthracene with paraformaldehyde and hydrochloric acid, giving the 9,10-bis-(chloromethyl)anthracene derivative, which then is treated with sodium in ethanol. Or anthracene can be reacted with vinylene carbonate, to give a cyclic carbonate which is hydrol- ised to the diol, which in turn is treated with lead tetraacetate in acetic acid to give the 9,10-anthracenedicarboxaldehyde. Or 9,10-anthracenediacetonitrile, a substituted hydrazine hyrochloride, sodium acetate and Raney nickel is reduced with hydrogen to give the anthracene bis-hydrazone.

  已公开的蒽-9,10-双羰基-利德拉宗及其衍生物可用于抑制移植小鼠肿瘤的生长，以及诱导白血病和相关癌症的消退和/或缓解。 这些化合物可由式表示： 其中 Z 是三价分子，选自由下列式子组成的组 其中 n 为 0、1、2 或 3，R 为氢、低级烷基、环烷基、苯基或苄基；R1 为氢或低级烷基；R2 选自由下列式子组成的组 其中 p 是 1、2 或 3，q 是 0、1 或 2，R' 是氢或低级烷基，R" 是低级烷基 R7 是式中的分子： 其中 m 是 2、3、4 或 5，R1、R' 和 R" 如前定义，分子 -NR'R" 可以是吡咯烷基、哌啶基、吗啉基或 N-甲基哌嗪基，X 是异氧代（O=）、其中 R' 如前定义），R3、R4、R5 和 R6 各自单独选自氢、卤素、羟基、硝基、氨基、磺酰胺基、低级烷基组成的组；以及药理学上可接受的酸加成盐和季铵盐。 这些化合物可通过 9,10-蒽二醛与肼反应制备。二甲醛是由蒽与多聚甲醛和盐酸反应得到的，从而得到 9,10-双（氯甲基）蒽衍生物，然后用钠在乙醇中进行处理。或者将蒽与碳酸乙烯酯反应，生成环状碳酸酯，碳酸酯与二元醇反应生成二元醇，二元醇在乙酸中与四乙酸铅反应生成 9,10-蒽二甲醛。或者将 9,10-蒽二乙腈、取代的盐酸肼、醋酸钠和雷尼镍与氢还原，得到蒽双腙。
• Preparation of 5,5-dimethyl-2-hydrazino-1,4,5,6-tetrahydropyrimidine hydrohalide
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0034250A1

  公开（公告）日：1981-08-26

  A process for preparing 5,5-dimethyl-2-hydrazino-1,4,5,6-tetrahydropyrimidine hydrohalide by reacting neopentyldiamine with a guanidine hydrohalide followed by treating the so-formed reaction product with hydrazine to yield the desired tetrahydropyrimidine hydrohalide. Alternatively, neopentyldiamine, guanidine hydrohalide and hydrazine can be admixed and reacted to yield the desired tetrahydropyrimidine hydrohalide.

  一种制备 5,5-二甲基-2-肼基-1,4,5,6-四氢嘧啶氢卤化物的工艺，先将新戊二胺与胍氢卤化物反应，然后用肼处理反应生成物，得到所需的四氢嘧啶氢卤化物。或者，也可以将新戊二胺、氢化胍和肼混合并反应，生成所需的四氢嘧啶氢卤化物。
• 2-hydrazino-1H-imidazoles
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0146711A2

  公开（公告）日：1985-07-03

  This disclosure describes platinum chelates of 2- hydrazino-1-aza(or 1,3-diaza)-1-cyclo-alkenes which possess activity as antitumor agents.

  本公开介绍了具有抗肿瘤活性的 2- 肼基-1-氮杂（或 1,3-二氮杂）-1-环烯的铂螯合物。
• Pentadienone hydrazone, and its use as insecticidal agent
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0008854B1

  公开（公告）日：1983-03-09
• Process for preparing 2-hydrazino-1,3-diazacycoalk-2-ene hydrohalides
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0158020B1

  公开（公告）日：1988-05-25