2-formyl-2',5-dihydroxy-5'-methyl-3,3'-dimethoxybenzophenone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-formyl-2',5-dihydroxy-5'-methyl-3,3'-dimethoxybenzophenone
• 英文别名: 4-Hydroxy-2-(2-hydroxy-3-methoxy-5-methylbenzoyl)-6-methoxybenzaldehyde
• 化学式: C₁₇H₁₆O₆
• 分子量: 316.31
• InChiKey: KPTNCHGMLXFDLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-formyl-2',5-dihydroxy-5'-methyl-3,3'-dimethoxybenzophenone 在 sodium chlorite 、 sodium dihydrogenphosphate 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 1.08h， 以3.6 mg的产率得到daldinolide B
  参考文献：
  名称：

  Isoindolinones, Phthalides, and a Naphthoquinone from the Fruiting Body of Daldinia concentrica

  摘要：

  A chemical investigation of the ascomycetes of Daldinia concentrica was performed using silica gel column chromatography, ODS column chromatography, and preparative HPLC. Two new isoindolinone compounds, daldinans B (1) and C (2), two new phthalide compounds, daldinolides A (3) and B (4), and a new naphthoquinone, daldiquinone (5), were isolated together with two known compounds (6 and 7). The structures of 1, 2, and 5 were established using NMR, MS, and IR methods, and the structures of 3 and 4 were determined by derivatization from known compounds (6 and 7). 5 exhibited antiangiogenesis activity against HUVECs (IC50 = 7.5 mu M).

  DOI：

  10.1021/acs.jnatprod.7b00976

文献信息

• Structures of a Novel Binaphthyl and Three Novel Benzophenone Denvatives with Plant-Growth Inhibitory Activity from the Fungus Daldinia concentrica.
  作者：Toshihiro HASHIMOTO、Shigenobu TAHARA、Shigeru TAKAOKA、Motoo TORI、Yoshinori ASAKAWA

  DOI：10.1248/cpb.42.1528

  日期：——

  A novel binaphthyl (1) and three novel benzophenone derivatives (2-4) have been isolated from the fungus (Ascomycetes) Daldinia concentrica. Their structures have been established by a combination of high resolution NMR spectra, X-ray crystallographic analysis and chemical degradation. Compounds 2 and 3 possess plant-growth inhibitory activity.

  从真菌（子囊菌）Daldinia concentrica 中分离出了一种新型二萘基（1）和三种新型二苯甲酮衍生物（2-4）。通过结合使用高分辨率核磁共振光谱、X 射线晶体分析和化学降解方法，我们确定了它们的结构。化合物 2 和 3 具有抑制植物生长的活性。
• Biologically Active Substances of Japanese Inedible Mushrooms
  作者：Yoshinori Asakawa、Toshihiro Hashimoto

  DOI：10.3987/rev-97-sr(n)6

  日期：——