二甲基羟基天冬氨酸盐 | 471242-80-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 二甲基羟基天冬氨酸盐
• 英文名称: dimethyl β-hydroxyaspartate
• 英文别名: Dimethyl 2-amino-3-hydroxybutanedioate
• CAS: 471242-80-5
• 化学式: C₆H₁₁NO₅
• 分子量: 177.157
• InChiKey: FKPFNKFGJIMFFG-UHFFFAOYSA-N

物化性质

• 沸点：
  299.0±40.0 °C(Predicted)
• 密度：
  1.298±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于乙酸乙酯、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  98.8
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  二甲基羟基天冬氨酸盐 、 (S)-2-[tert-Butoxycarbonyl-((E)-1-carboxy-2-methyl-but-1-enyl)-aminocarbonyl]-2,5-dihydro-pyrrole-1-carboxylic acid tert-butyl ester 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 作用下， 以79%的产率得到2-{(E)-2-[tert-Butoxycarbonyl-((S)-1-tert-butoxycarbonyl-2,5-dihydro-1H-pyrrole-2-carbonyl)-amino]-3-methyl-pent-2-enoylamino}-3-hydroxy-succinic acid dimethyl ester
  参考文献：
  名称：

  形成脱氢氨基酸的立体特异性消除：幻视素三肽侧链的合成

  摘要：

  近年来，基于它们作为商品化学品的重要性以及它们在生物活性天然产品中的存在，人们对 R,â-脱氢氨基酸越来越感兴趣。R,â-脱氢氨基酸不对称氢化的有效方法允许获得多种非天然氨基酸。1 脱氢氨基酸也存在于许多天然产物中，包括抗霉素、腱毒素和磷酸酶抑制剂微囊藻毒素和节球藻毒素。2 不饱和由于烯烃的存在，氨基酸引入了构象刚性元素以及反应性的变化。 3 在本报告中，我们描述了一种有效的立体选择性方法，用于从现成的 α-羟基氨基酸合成 R,α-脱氢氨基酸.

  DOI：

  10.1021/ja991037q

文献信息

• Rheology control agents
  申请人：Lenges Peter Christian

  公开号：US20060155146A1

  公开（公告）日：2006-07-13

  The present invention provides for a rheology control agent that includes a following compound represented by the following formula: wherein A, B, C and D equal CH 2 , CHR, NH, or O, and A, B, C and D may be the same or different and at least one of A and B equals NH and at least one of C and D equals NH; and wherein R 1 , R 2 , and R 3 may be the same or different and represent a linear, branched, hyper-branched, or dendritic ether, polyether or hydrocarbon based chain, optionally forming at least one carbon-based ring, being saturated or unsaturated and R 2 represents linear or branched alkylenes, ethers, polyethers, or polyester linkages and at least one of R 1 , R 2 , and R 3 comprises an ester group or an amide group which is branched off from the main chain; excluded from Formula (1) is a compound wherein R 2 is CH 2 —CH 2 —CH 2 —CH 2 —CH(C(O)OCH 3 ), A, B, C, and D are equal to NH and R 1 and R 3 are both equal to a linear octyl hydrocarbon chain; the rheology control agent is suitable for solvent-borne and water-borne coating composition having improved rheology control useful for OEM refinishing or repainting the exterior of automobile and truck bodies and parts thereof.

  本发明提供了一种流变控制剂，包括下式所示的化合物：其中A、B、C和D等于CH2、CHR、NH或O，A、B、C和D可以相同也可以不同，且至少有一个A和B等于NH，至少有一个C和D等于NH；R1、R2和R3可以相同也可以不同，表示线性、支链、超支链或树枝状醚、聚醚或碳氢基链，可选地形成至少一个碳基环，饱和或不饱和，其中R2表示线性或支链烷基、醚、聚醚或聚酯键合，且R1、R2和R3中至少有一个包括从主链上分支出的酯基或酰胺基；式（1）中不包括R2为CH2—CH2—CH2—CH2—CH(C(O)OCH3)、A、B、C和D均等于NH，且R1和R3均等于线性辛基碳氢链的化合物；该流变控制剂适用于改善流变控制的溶剂型和水性涂料组合物，可用于汽车和卡车车身及其零部件的OEM翻新或重新涂装。
• Coating compositions containing rheology control agents
  申请人：Lenges Peter Christian

  公开号：US20060155021A1

  公开（公告）日：2006-07-13

  The present invention provides for a coating composition containing a rheology control agent having improved rheology control particularly in low VOC solvent-borne coating compositions and water-borne coating compositions useful for OEM refinishing or repainting the exterior of automobile and truck bodies and parts thereof; the rheology control agent used in the coating composition comprises the following compound represented by the following formula wherein A, B, C and D equal CH 2 , CHR, NH, or O, and A, B, C and D may be the same or different and at least one of A and B equals NH and at least one of C and D equals NH; and wherein R 1 , R 2 , and R 3 are described in the specification.

  本发明提供了一种含有流变控制剂的涂料组合物，该流变控制剂尤其在低挥发性有机化合物溶剂型涂料组合物和水性涂料组合物中具有更好的流变控制效果，该涂料组合物可用于汽车和卡车车身及其部件的OEM修补或重新涂装；该涂料组合物中使用的流变控制剂包括下式所代表的以下化合物 其中 A、B、C 和 D 等于 CH 2 、CHR、NH 或 O，且 A、B、C 和 D 可以相同或不同，A 和 B 中至少有一个等于 NH，C 和 D 中至少有一个等于 NH；以及 其中 R 1 , R 2 和 R 3 在说明书中有所描述。
• COATING COMPOSITIONS CONTAINING RHEOLOGY CONTROL AGENTS
  申请人：E.I. du Pont de Nemours and Company

  公开号：EP1838749A1

  公开（公告）日：2007-10-03
• SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
  申请人：GlaxoSmithKline LLC

  公开号：EP2997029B1

  公开（公告）日：2019-01-09
• Rheology Control Agents
  申请人：Lenges Christian Peter

  公开号：US20100204376A1

  公开（公告）日：2010-08-12

  The present invention provides for a rheology control agent that includes a following compound represented by the following formula: wherein A, B, C and D equal CH 2 , CHR, NH, or O, and A, B, C and D may be the same or different and at least one of A and B equals NH and at least one of C and D equals NH; and wherein R 1 , R 2 , and R 3 may be the same or different and represent a linear, branched, hyper-branched, or dendritic ether, polyether or hydrocarbon based chain, optionally forming at least one carbon-based ring, being saturated or unsaturated and R 2 represents linear or branched alkylenes, ethers, polyethers, or polyester linkages and at least one of R 1 , R 2 , and R 3 comprises an ester group or an amide group which is branched off from the main chain; excluded from Formula (1) is a compound wherein R 2 is CH 2 —CH 2 —CH 2 —CH 2 —CH(C(O)OCH 3 ), A, B, C, and D are equal to NH and R 1 and R 3 are both equal to a linear octyl hydrocarbon chain; the rheology control agent is suitable for solvent-borne and water-borne coating composition having improved rheology control useful for OEM refinishing or repainting the exterior of automobile and truck bodies and parts thereof.