5,7-dimethyl-2,1-benzisothiazole | 69719-20-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5,7-dimethyl-2,1-benzisothiazole
• 英文别名: 5.7-Dimethyl-benzo(c)-1λ⁴.2-thiazol；5,7-Dimethyl-2,1-benzothiazole
• CAS: 69719-20-6
• 化学式: C₉H₉NS
• 分子量: 163.243
• InChiKey: KPAISARRFWYKMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5,7-dimethyl-2,1-benzisothiazole 在 硫酸 、 硝酸 作用下， 反应 0.5h， 以90%的产率得到5,7-dimethyl-4-nitro-2,1-benzisothiazole
  参考文献：
  名称：

  Danylec, Basil; Davis, Michael, Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 533 - 536

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4,6-三甲基苯胺 在 N-sulfinylmethanesulfonamide 作用下， 以48%的产率得到5,7-dimethyl-2,1-benzisothiazole
  参考文献：
  名称：

  Danylec, Basil; Davis, Michael, Journal of Heterocyclic Chemistry, 1980, vol. 17, p. 533 - 536

  摘要：

  DOI：

文献信息

• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• DANYLEC B.; DAVIS M., J. HETEROCYCL. CHEM., 1980, 17, NO 3, 533-536
  作者：DANYLEC B.、 DAVIS M.

  DOI：——

  日期：——
• KLINGEBIEL U.; BENTMANN D., Z. NATURFORSCH., 1979, B 34, NO 1, 123-124
  作者：KLINGEBIEL U.、 BENTMANN D.

  DOI：——

  日期：——
• METHOD FOR EXPANDING HEMATOPOIETIC STEM CELLS USING HETEROCYCLIC COMPOUND
  申请人：Nishino Taito

  公开号：US20100266556A1

  公开（公告）日：2010-10-21

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various hematopoietic disorders is provided. A method for expanding hematopoietic stem cells and/or hematopoietic progenitor cells, which comprises culturing hematopoietic stem cells and/or hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein X, Y, X, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined in the description), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof.
• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：The UNIVERSITY OF TOKYO

  公开号：US20140227780A1

  公开（公告）日：2014-08-14

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, including separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) where R 1 to R 7 , W, X, Y, Z, Ar 1 and n are as defined in the description to differentiate them into megakaryocytes and/or platelets.