10-Methyl-phenothiazinyl-(1)-essigsaeure | 17800-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 10-Methyl-phenothiazinyl-(1)-essigsaeure
• 英文别名: (10-methyl-10H-phenothiazin-1-yl)-acetic acid；2-(10-Methylphenothiazin-1-yl)acetic acid
• CAS: 17800-37-2
• 化学式: C₁₅H₁₃NO₂S
• 分子量: 271.34
• InChiKey: KAHRFLNLZKQCCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  65.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-oxochromen-2-carbonyl azide 、 10-Methyl-phenothiazinyl-(1)-essigsaeure 生成 2-(10-methyl-10H-phenothiazin-2-yl)-N-(4-oxo-4H-chromen-2-yl)-acetamide
  参考文献：
  名称：

  PAYARD M.; PARIS J.; COUQUELET J.; BASTIDE J.; ZAPALUS PH., EUR. J. MED. CHEM., 1976, 11, NO 1, 13-18

  摘要：

  DOI：

文献信息

• Method of delivering drug with aid of effervescent activity generated in environment of use
  申请人：ALZA CORPORATION

  公开号：EP0040899A2

  公开（公告）日：1981-12-02

  An osmotically driven device for dispensing an active agent into a fluid environment is disclosed, which device comprises a semipermeable wall surrounding and defining an inner compartment containing an active agent having limited solubility in the fluid, an outlet passageway through the wall for connecting the compartment with the exterior 'of the device for dispensing the active agent, the device characterized in that the compartment contains a basic compound that generates carbon dioxide gas on being dispensed from the compartment, thereby improving the delivery of the active agent from the device.

  本发明公开了一种将活性剂分配到流体环境中的渗透压驱动装置，该装置包括一个围绕并限定内室的半透壁，内室中含有在流体中溶解度有限的活性剂；一个穿过壁的出口通道，用于连接内室与装置外部'以分配活性剂；该装置的特征在于，内室中含有一种碱性化合物，从内室分配活性剂时会产生二氧化碳气体，从而改善活性剂从装置中的输送。
• Dosage form with means for governing rate of gas formation
  申请人：ALZA CORPORATION

  公开号：EP0250083A2

  公开（公告）日：1987-12-23

  A dosage form (20) for delivering a beneficial drug formulation (26) to an environment of use, comprising: a) a wall (22) comprising at least in part a composition permeable to the passage of fluid and substantially impermeable to the passage of a drug formulation (26) which wall surrounds and defines; b) a compartment (25); c) a dosage amount of a beneficial drug formulation in the compartment; and d) exit means (23) in the wall of the dosage form that connects compartment (25) with the exterior of the dosage form for delivering the drug formulation (26) from the dosage form; characterised by e) means for producing a biologically acceptable gas (27) in the compartment, said means comprising a pharmaceutically acceptable gas release rate controlling means (28); characterised by c) a dosage amount of an anti-inflammatory drug selected from an acylcarboxylic acid or enolic acid anti-inflammatory drug in the compartment (25); and by d) means (27) for producing gaseous carbon dioxide in the compartment, said means comprising a polymeric film (28) surrounding a member selected from a carbonate and bicarbonate.

  一种将有益药物制剂（26）输送到使用环境中的剂型（20），包括 a) 壁（22），该壁至少部分由可渗透流体并基本不透过药物制剂（26）的成分组成，该壁包围并限定了药物制剂（26）； b) 隔室（25） c) 小室中有益药物制剂的剂量；以及 d) 位于剂型壁上的出口装置（23），用于连接隔室（25）和剂型外部，以便将药物制剂 （26）从剂型中输送出来； 其特征是 e) 在隔室中产生生物可接受气体（27）的装置，所述装置包括药物可接受气体释放速率控制装置（28）； 其特征是 d) 在隔室中产生气态二氧化碳的装置（27），所述装置包括围绕选自碳酸盐和碳酸氢盐的构件的聚合物薄膜（28）。
• US4265874A
  申请人：——

  公开号：US4265874A

  公开（公告）日：1981-05-05
• US4391814A
  申请人：——

  公开号：US4391814A

  公开（公告）日：1983-07-05
• US4344929A
  申请人：——

  公开号：US4344929A

  公开（公告）日：1982-08-17