2-methyl-3-phenylindolizin-1-yl acetate | 58476-05-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-methyl-3-phenylindolizin-1-yl acetate
• 英文别名: 1-(acetyloxy)-2-methyl-3-(phenyl)indolizine；2-Methyl-3-phenyl-1-indolizinylacetat；1-acetoxy-2-methyl-3-phenyl-indolizine；(2-Methyl-3-phenylindolizin-1-yl) acetate
• CAS: 58476-05-4
• 化学式: C₁₇H₁₅NO₂
• 分子量: 265.312
• InChiKey: XUDUENDULIYZPR-UHFFFAOYSA-N

物化性质

• 密度：
  1.13±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 3.0h， 生成 2-methyl-3-phenylindolizin-1-yl acetate
  参考文献：
  名称：

  A novel and efficient approach to highly substituted indolizines via 5-endo-trig iodocyclization

  摘要：

  A new approach to indolizines has been developed using a 5-endo-trig iodocyclization of allylic esters followed by isomerization and dehydroiodination facilitated by triethylamine at rt This mild procedure enabled us to synthesize a number of highly substituted indolizines in good yields. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2007.10.037

文献信息

• Desulfitative palladium-catalyzed direct C-3 arylation of indolizines with arylsulfonyl chlorides
  作者：Wei Zhang、Fang Liu、Baoli Zhao

  DOI：10.1002/aoc.3326

  日期：2015.8

  Pd‐catalyzed desulfitative approach to C‐3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1‐methyl‐2‐pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C‐3 arylation of indolizines

  已经开发了一种高效的Pd催化的吲哚嗪衍生物C-3芳基化脱硫方法，并且该方案使用易于获得的芳基磺酰氯作为氮气氛下的芳基化试剂。这种转化是在1-甲基-2-吡咯烷酮和二甲氧基乙烷的混合溶剂中使用简单的三苯基膦作为配体进行的，这为吲哚嗪的C-3芳基化提供了一种新方法。版权所有©2015 John Wiley＆Sons，Ltd.
• Intramolecular CN Bond Formation under Metal-free Conditions: Synthesis of Indolizines
  作者：Junliang Wu、Wei Lin Leng、Hongze Liao、Kim Le Mai Hoang、Xue-Wei Liu

  DOI：10.1002/asia.201403400

  日期：2015.4

  Polysubstituted indolizine derivatives are constructed via intramolecular CN bond formation/CH bond cleavage under metal‐free conditions. These methods offer straightforward pathways to transform pyridyl chalcones into a variety of indolizines.

  多取代的中氮茚衍生物经由分子内Ç构造 N键形成/ C 不含金属的条件下，H键裂解。这些方法提供了将吡啶基查耳酮转化为多种吲哚嗪的直接途径。
• POHJAHLA E., ACTA CHEM. SCAND. <ACSA-A4>, 1975, B29, NO 10, 1079-1084
  作者：POHJAHLA E.

  DOI：——

  日期：——