methiozolin | 403640-27-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methiozolin
• 英文别名: 5-{(2,6-difluorobenzyloxy)methyl}-4,5-dihydro-5-methyl-3-(3-methylthiophene-2-yl)-isoxazole；methiozoline；5-[(2,6-difluorophenyl)methoxymethyl]-5-methyl-3-(3-methylthiophen-2-yl)-4H-1,2-oxazole
• CAS: 403640-27-7
• 化学式: C₁₇H₁₇F₂NO₂S
• 分子量: 337.39
• InChiKey: OPEJGICLTMWFNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-甲基噻吩醛 在 sodium hydroxide 、 N-氯代丁二酰亚胺 、 盐酸羟胺 、 sodium hydride 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.25h， 生成 methiozolin
  参考文献：
  名称：

  5-(2,6-Difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)- 1,2-isoxazoline as a Useful Rice Herbicide

  摘要：

  5-(2,6-Difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)-1,2-isoxazoline derivative was synthesized, and its herbicidal activity was assessed under glasshouse and flooded paddy conditions. 5-(2,6-Difluorobenzyl)oxymethyl-5-methyl-3-(3-methylthiophen-2-yl)-1,2-isoxazoline demonstrated good rice selectivity and potent herbicidal activity against annual weeds at 125 g of a.i. ha(-1) under greenhouse conditions. Soil application of this compound showed complete control of barnyardgrass to the fourth leaf stage at 250 g of a.i. ha(-1). Field trials indicated that this compound controlled annual weeds rapidly with a good tolerance on transplanted rice seedlings by postemergence and soil application. This compound showed a low mammalian and environmental toxicity in various toxicological tests.

  DOI：

  10.1021/jf051284f

文献信息

• [EN] HERBICIDAL ISOXAZOLINE DERIVATIVES<br/>[FR] DÉRIVÉS D'ISOXAZOLINE HERBICIDES
  申请人：SYNGENTA LTD

  公开号：WO2011033251A1

  公开（公告）日：2011-03-24

  The present invention relates to isoxazoline-oxime derivatives of formula (I); where R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for making compounds of formula (1), to herbicidal compositions comprising these compounds and to methods of using these compounds to control plant growth.

  本发明涉及式(I)的异噁唑啉-肟衍生物；其中R1、R2、R3、R4、R5、R6、R7、R8和X如权利要求1所定义；或其盐或N-氧化物。此外，本发明涉及制备式(1)化合物的过程和中间体，涉及包含这些化合物的除草剂组合物，以及使用这些化合物控制植物生长的方法。
• [EN] N-OXY PYRAZOLO-TRIAZEPINE-DIONE DERIVATIVES<br/>[FR] DÉRIVÉS N-OXY PYRAZOLO-TRIAZÉPINE-DIONE
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2012175666A1

  公开（公告）日：2012-12-27

  Compounds of formula (I) wherein the substituents are as defined in claim 1, are useful as a pesticides and herbicides.

  式（I）中的化合物，其中取代基如权利要求1中所定义的那样，可用作杀虫剂和除草剂。
• [EN] SUBSTITUTED PYRIMIDINES AND TRIAZINES AS HERBICIDES<br/>[FR] PYRIMIDINES ET TRIAZINES SUBSTITUÉES UTILISÉES EN TANT QU'HERBICIDES
  申请人：FMC CORP

  公开号：WO2021183980A1

  公开（公告）日：2021-09-16

  Disclosed are compounds of Formula I, stereoisomers, TV-oxides, and salts thereof, wherein; A is selected from A-2, A-2, A-3, A-4, A-5, A-6, A-7, A-8, A-9 and A-10 and A, A-l, A-2, A-3, A-4, A-5, A-6, A-7, A-8, A-9, A-10, R1 through R20b, W, X and Y are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

  公开的是Formula I的化合物，立体异构体，TV-氧化物及其盐，其中；A从A-2，A-2，A-3，A-4，A-5，A-6，A-7，A-8，A-9和A-10中选择，A，A-l，A-2，A-3，A-4，A-5，A-6，A-7，A-8，A-9，A-10，R1到R20b，W，X和Y如披露中定义。还公开了含有Formula I化合物的组合物以及用于控制不受欢迎植被的方法，包括将不受欢迎的植被或其环境与本发明的化合物或组合物的有效量接触。
• [EN] 1 - AZA - SPIRO [4.5] DEC- 3 - ENE AND 1, 8 - DIAZA - SPIRO [4.5 ] DEC- 3 - ENE DERIVATIVES AS PESTICIDES<br/>[FR] DÉRIVÉS DE 1-AZA-SPIRO[4.5]DÉC-3-ÈNE ET DE 1,8-DIAZA-SPIRO[4.5]DÉC-3-ÈNE EN TANT QUE PESTICIDES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2013150015A1

  公开（公告）日：2013-10-10

  A compound of the formula (I), wherein the substituents are as defined in claim 1, are useful as a pesticides.

  式（I）的化合物，其中取代基如权利要求1所定义的那样，可用作杀虫剂。
• [EN] PYRROLIDINONES AS HERBICIDES<br/>[FR] PYRROLIDINONES SERVANT D'HERBICIDES
  申请人：DU PONT

  公开号：WO2015084796A1

  公开（公告）日：2015-06-11

  Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof;. whereinRl,R2,R3,R4, R5, R6, Ql, Q2,yl, and Y2are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling undesired vegetation comprising contacting the undesired vegetation or its environment with an effective amount of a compound or a composition of the invention.

  公开了Formula 1的化合物，包括所有立体异构体、N-氧化物和盐；其中R1、R2、R3、R4、R5、R6、Q1、Q2、y1和y2如披露中定义。还公开了含有Formula 1化合物的组合物以及用于控制不受欢迎植被的方法，包括将不受欢迎的植被或其环境与本发明的化合物或组合物的有效量接触。