The invention concerns a method for preparing optionally substituted 3-indolcarboxylic acid esters, with hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-one. The invention is characterized in that the optionally substituted 3-indolcarboxylic acid is converted by means of a suitable halogenating agent, into corresponding acid halide, preferably corresponding acid chloride, and the latter is transformed with hexahydro-8-hydroxy-2,6-methano-2H-chinolizin-3(4H)-one. The invention is characterized in that the entire reaction occurs in acid medium with a maximum pH of 7.
本发明涉及一种制备可选取代的3-
吲哚羧酸酯的方法,使用六氢-8-羟基-2,6-甲基-2H-
喹啉-3(4H)-酮。本发明的特点在于,通过适当的卤化剂将可选取代的3-
吲哚羧酸转化为相应的酸卤化物,优选相应的酸
氯化物,然后将其与六氢-8-羟基-2,6-甲基-2H-
喹啉-3(4H)-酮反应。本发明的特点在于,整个反应在酸性介质中进行,pH值最大为7。