麦根酸 | 69199-37-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 麦根酸
• 英文名称: mugineic acid
• 英文别名: (2S)-1-[(2S,3S)-3-carboxy-3-[[(3S)-3-carboxy-3-hydroxypropyl]amino]-2-hydroxypropyl]azetidine-2-carboxylic acid
• CAS: 69199-37-7
• 化学式: C₁₂H₂₀N₂O₈
• 分子量: 320.299
• InChiKey: GJRGEVKCJPPZIT-JBDRJPRFSA-N

物化性质

• 溶解度：
  可微溶于水

计算性质

• 辛醇/水分配系数(LogP)：
  -6.7
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  168
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  benzyl N-<(2S,2'S,3S)-3'-tert-butoxycarbonylamino-3'-benzyloxycarbonyl-2'-tert-butyldimethylsiloxypropyl>-2-azetidinecarboxylate 生成 麦根酸
  参考文献：
  名称：

  HAMADA, YASUMASA;IWAI, KIYOTAKA;SHIOIRI, TAKAYUKI, TETRAHEDRON LETT., 31,(1990) N5, C. 5041-5042

  摘要：

  DOI：

文献信息

• [EN] ANTIBACTERIAL SIDEROMYCINS<br/>[FR] SIDÉROMYCINES ANTIBACTÉRIENNES
  申请人：MILLER MARVIN J

  公开号：WO2016027262A1

  公开（公告）日：2016-02-25

  A compound, comprising: an Fe(III)-binding and/or Fe(III)-bound siderophore; one or more optional linker covalently bound to the siderophore; and daptomycin covalently bound to the linker, or, if no linker is present, then to the siderophore; or pharmaceutically acceptable salt or solvate thereof.

  一种化合物，包括：与Fe(III)结合和/或Fe(III)结合的铁载体；一个或多个可选的与铁载体共价结合的连接剂；以及共价结合到连接剂的达托霉素，或者如果没有连接剂存在，则共价结合到铁载体；或其药用可接受的盐或溶剂。
• [EN] COMPOSITIONS AND METHODS FOR PREPARING AND USING AZETIDINES<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE PRÉPARATION ET D'UTILISATION D'AZÉTIDINES
  申请人：UNIV VIRGINIA PATENT FOUNDATION

  公开号：WO2019204740A1

  公开（公告）日：2019-10-24

  The present disclosure provides azetidine compounds of Formula I and their pharmaceutically acceptable salts, their compositions, and methods for their use in determining azetidine compound binding to proteins. The azetidine compounds are useful as probes, for monitoring diacylglycerol kinase activity, and for identifying druggable targets.

  本公开提供了Formula I的氮杂环化合物及其药用盐，它们的组合物，以及它们在确定氮杂环化合物与蛋白质结合方面的使用方法。这些氮杂环化合物可用作探针，用于监测二酰基甘油激酶活性，并用于识别可药用的靶标。
• EFFECTIVE PRODUCTION PROCESS FOR MUGINEIC ACID COMPOUND
  申请人：Suntory Holdings Limited

  公开号：EP2103599A1

  公开（公告）日：2009-09-23

  A method for producing mugineic acids, which is represented by the following scheme: (wherein R1 and R2 represent a hydrogen atom or a hydroxyl group, R3 represents a hydroxyl group or an amino group, R4 and R7 represent a hydrogen atom or a protecting group of a carboxyl group, R5 represents a protecting group of an amino group, R6 represents a protecting group of a carboxyl group, and R8 represents -OR9 (wherein R9 represents a protecting group of a hydroxyl group) or -NHR10 (wherein R10 represents a protecting group of an amino group)).

  一种生产麦角酸的方法，由以下方案代表：（其中R1和R2代表氢原子或羟基，R3代表羟基或氨基，R4和R7代表氢原子或羧基的保护基，R5代表氨基的保护基，R6代表羧基的保护基，R8代表-OR9（其中R9代表羟基的保护基）或-NHR10（其中R10代表氨基的保护基）。
• [EN] CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS<br/>[FR] PEROXYDES CYCLIQUES UTILISÉS EN TANT QUE PROMÉDICAMENTS POUR L'ADMINISTRATION SÉLECTIVE D'AGENTS
  申请人：UNIV CALIFORNIA

  公开号：WO2015123595A1

  公开（公告）日：2015-08-20

  Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa- 8-azaspiro[4.5] decane. Also disclosed is a pharmaceutical composition containing the compound and a phannaceutically acceptable carrier.

  本文披露了前药组合物及其用于治疗和检测疾病的方法。具体地，本文披露了一种具有螺合1,2,4-三噁烷和哌啶环的化合物的公式(I)，即1,2,4-三氧杂-8-氮杂螺[4.5]癸烷。还披露了含有该化合物和药用载体的药物组合物。
• GLYCERO-COMPOUND HAVING TRIPLE BOND AND MEMBRANE MATERIAL CONTAINING THE SAME
  申请人：BABA Teruhiko

  公开号：US20070105823A1

  公开（公告）日：2007-05-10

  The present invention provides a chemically stable and novel glycero-compound having one or two triple bonds, one molecule of a glycerol and one or two molecules of a fatty alcohol having a triple bond being linked through an ether bond, an organic group being linked to residual hydroxyl groups of the glycerol, which can be used as a membrane material for forming a vesicle membrane due to its high intermolecular cohesive force, and also provides a membrane forming material containing the same. The glycero-compound has a triple bond represented by the following general formula (1): wherein n and m each represents a number of 1 to 17 and the total (n+m) is a number of 4 to 18, n and m may be the same or different, and R represents a hydrogen atom, a metal atom, a phosphoric acid group, or an organic group which may be linked through a phosphoric acid group.

  本发明提供了一种化学稳定且新颖的甘油化合物，其中含有一个或两个三键，一个甘油分子和一个或两个含有三键的脂肪醇分子通过醚键连接，有机基与甘油的残余羟基连接，由于其高分子间内聚力可用作形成囊泡膜的膜材料，还提供了含有相同物质的膜形成材料。该甘油化合物具有以下一般式（1）所代表的三键：其中n和m分别表示1到17之间的数字，总数（n+m）为4到18之间的数字，n和m可以相同也可以不同，R表示氢原子、金属原子、磷酸基或可以通过磷酸基连接的有机基。