{3-[4-(5-chloro-3-pyrimidin-5-yl-1H-pyrrolo[2,3-b]pyridin-2-yl)phenoxy]-2-methoxypropyl}dimethylamine | 664991-51-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: {3-[4-(5-chloro-3-pyrimidin-5-yl-1H-pyrrolo[2,3-b]pyridin-2-yl)phenoxy]-2-methoxypropyl}dimethylamine
• 英文别名: {3-[4-(5-chloro-3-pyrimidin-5-yl-1H-pyrrolo[2,3-b]pyridin-2-yl)phenoxy]-2-methoxpropyl}dimethylamine；3-[4-(5-chloro-3-pyrimidin-5-yl-1H-pyrrolo[2,3-b]pyridin-2-yl)phenoxy]-2-methoxy-N,N-dimethylpropan-1-amine
• CAS: 664991-51-9
• 化学式: C₂₃H₂₄ClN₅O₂
• 分子量: 437.929
• InChiKey: VUXKONBSFSSKOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-氯-2-碘-3-(5-嘧啶)-1H-吡咯并[2,3-B]吡啶 、 {2-methoxy-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]propyl}dimethylamine 生成 {3-[4-(5-chloro-3-pyrimidin-5-yl-1H-pyrrolo[2,3-b]pyridin-2-yl)phenoxy]-2-methoxypropyl}dimethylamine
  参考文献：
  名称：

  Substituted pyrrolopyridines

  摘要：

  提供了公式（I）的新化合物，其中R1、R2和R3如规范中定义，并且其药学上可接受的盐；以及它们的制备过程、含有它们的组合物和它们在治疗中的用途。这些化合物是Itk激酶的抑制剂。

  公开号：

  US20050261331A1

文献信息

• [EN] SUBSTITUTED PYRROLOPYRIDINES<br/>[FR] PYRROLOPYRIDINES SUBSTITUES
  申请人：ASTRAZENECA AB

  公开号：WO2004016609A1

  公开（公告）日：2004-02-26

  There are provided novel compounds of formula (I) wherein R1, R2 and R3 are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.

  提供了式(I)的新化合物，其中R1、R2和R3如规范中所定义，并且其药学上可接受的盐；以及它们的制备方法、含有它们的组合物以及它们在治疗中的用途。这些化合物是激酶Itk的抑制剂。
• Ruthenium complexes, process for preparation thereof, and processes for producing open-ring polymer of cycloolefins and hydrogenation products thereof by using the complex as catalyst
  申请人：Sakamoto Masato

  公开号：US20050014916A1

  公开（公告）日：2005-01-20

  The present invention relates to ruthenium complex compound wherein a heteroatom-containing carbene compound having a six-membered ring structure is bonded to ruthenium and a process for the preparation thereof; a process for producing ring-opened cyclic olefin polymer by subjecting a cyclic olefin to ring-opening metathesis polymerization in the presence of such a ruthenium complex compound; and a process for producing hydrogenated product of ring-opened cyclic olefin polymers by hydrogenating the carbon-carbon double bonds of the above ring-opened polymers. The invention gives hydrogenated product of ring-opened cyclic olefin polymers having physical properties different from those of hydrogenated product of ring-opened polymers of the prior art. Particularly, the use of dicyclopentadiene can give a hydrogenated product of ring-opened cyclic olefin polymer excellent in heat resistance, and this product can be advantageously used as parts or formed products for medical appliances or electrical components.

  本发明涉及一种钌配合物化合物，其中将具有六元环结构的含杂原子的卡宾化合物与钌结合，以及其制备方法；一种通过在此类钌配合物存在下将环状烯烃经环开环甲硫烯聚合制备环开环环状烯烃聚合物的方法；以及一种通过氢化上述环开环聚合物的碳碳双键制备环开环环状烯烃聚合物的氢化产物的方法。该发明提供了具有与先前技术中环开环聚合物氢化产物不同物理性质的环开环环状烯烃聚合物的氢化产物。特别地，使用二环戊二烯可以得到热性能优异的环开环环状烯烃聚合物的氢化产物，该产品可有利地用作医疗器械或电子元件的零部件或成型产品。
• SUBSTITUTED PYRROLOPYRIDINES
  申请人：AstraZeneca AB

  公开号：EP1539757A1

  公开（公告）日：2005-06-15