4,5,6,7,9,9a,10,11,12,13,14,14a-dodecahydrocyclohepta[c][1,4]diazepino [6,7,1-ij]quinoline | 620948-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 4,5,6,7,9,9a,10,11,12,13,14,14a-dodecahydrocyclohepta[c][1,4]diazepino [6,7,1-ij]quinoline
• 英文别名: 4,5,6,7,9,9a,10,11,12,13,14,14a-Dodecahydrocyclohepta[c][1,4]diazepino[6,7,1-ij]quinoline；10,13-diazatetracyclo[8.8.1.02,8.015,19]nonadeca-1(18),15(19),16-triene
• CAS: 620948-38-1
• 化学式: C₁₇H₂₄N₂
• 分子量: 256.391
• InChiKey: BHAKYGPGPDLCEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-acetyl-4,5,6,7,9,9a,10,11,12,13,14,14a-dodecahydrocyclohepta[c][1,4]diazepino[6,7,1-ij]quinoline 在 氢氧化钾 、 水 作用下， 以 甲醇 为溶剂， 反应 48.0h， 以63%的产率得到4,5,6,7,9,9a,10,11,12,13,14,14a-dodecahydrocyclohepta[c][1,4]diazepino [6,7,1-ij]quinoline
  参考文献：
  名称：

  [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents

  摘要：

  提供公式I的化合物或其药用可接受的盐：其中R1至R7在此处定义。公式I的化合物是5HT2c受体激动剂或部分激动剂，可用于治疗多种疾病。

  公开号：

  US20040009970A1

文献信息

• [1,4]Diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents
  申请人：Ramamoorthy Sivaramakrishnan P.

  公开号：US20070004707A1

  公开（公告）日：2007-01-04

  Compounds of Formula I or a pharmaceutically acceptable salt thereof are provided: where R 1 through R 7 are defined herein. The compounds of Formula I are 5HT2c agonists or partial agonists, and are useful for treating a variety of disorders.

  提供公式I的化合物或其药学上可接受的盐：其中R1到R7在此定义。公式I的化合物是5HT2c激动剂或部分激动剂，并且可用于治疗各种疾病。
• [1,4]diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents
  申请人：Wyeth LLC

  公开号：US07687620B2

  公开（公告）日：2010-03-30

  Compounds of Formula I or a pharmaceutically acceptable salt thereof are provided: where R1 through R7 are defined herein. The compounds of Formula I are 5HT2c agonists or partial agonists, and are useful for treating a variety of disorders.

  提供公式I或其药学上可接受的盐的化合物：其中R1到R7在此定义。公式I的化合物是5HT2c激动剂或部分激动剂，可用于治疗各种疾病。
• (1,4)DIAZEPINO(6,7,1-IJ)QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS
  申请人：Wyeth

  公开号：EP1497293B1

  公开（公告）日：2008-06-11
• Treatment of substance abuse
  申请人：Rosenzweig-Lipson Sharon

  公开号：US20070167438A1

  公开（公告）日：2007-07-19

  The present invention provides methods and compositions for use in the treatment, prevention, and/or alleviation of drug abuse and/or its symptoms. In particular, the invention demonstrates that compositions comprising compounds of formula I are useful in such treatment, prevention, and/or alleviation: or a pharmaceutically acceptable salt thereof, wherein each of n, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein.
• Methods for modulating bladder function
  申请人：Jacobson William

  公开号：US20070225274A1

  公开（公告）日：2007-09-27

  This invention provides methods and pharmaceutical compositions for modulating bladder function, and in particular for maintaining bladder control or treating urinary incontinence.