butylphosphate-5'-thymidine-3'-phosphatebutyl | 403717-06-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: butylphosphate-5'-thymidine-3'-phosphatebutyl
• 英文别名: (2R,3S)-2-((butoxy(hydroxy)phosphoryl)oxy)methyl-(5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl) butyl hydrogen phosphate；Bisphosphocin nu-3；[(2R,3S,5R)-3-[butoxy(hydroxy)phosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl butyl hydrogen phosphate
• CAS: 403717-06-6
• 化学式: C₁₈H₃₂N₂O₁₁P₂
• 分子量: 514.406
• InChiKey: ZXQBUNYVGNOEBQ-ARFHVFGLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  170
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  butylphosphate-5'-thymidine-3'-phosphatebutyl 在 sodium hydroxide 作用下， 以 水 为溶剂， 以48 %的产率得到disodium (2R,3S)-2-((butoxy(hydroxy)phosphoryloxy)methyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl butyl phosphate
  参考文献：
  名称：

  [EN] METHODS FOR PREPARING BISPHOSPHOCINS
  [FR] PROCÉDÉS DE PRÉPARATION DE BISPHOSPHOCINES

  摘要：

  Methods for synthesizing Bisphosphocins use chemical modification of dialcoholic compounds avoiding the use of tetrazole and tertiary butyl hydroperoxide.

  公开号：

  WO2023004130A1

文献信息

• Antimicrobial and Antiviral Compounds and Methods for Their Use
  申请人：Dale Roderic M.K.

  公开号：US20110135713A1

  公开（公告）日：2011-06-09

  The present invention provides protonated compounds having antiviral and antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi. The invention also provides antiviral compositions comprising compounds of the invention. Viruses that may be treated by compositions of the invention include, but are not limited to, HIV, HSV, CMV, HBV, HCV and influenza virus.

  本发明提供了具有抗病毒和抗微生物活性的质子化化合物。本发明还提供了包含本发明中的质子化合物的抗微生物组合物。本发明中的质子化合物提供了对耐药菌株和机会性真菌的有效抗微生物活性。本发明还提供了包含本发明化合物的抗病毒组合物。可以通过本发明组合物治疗的病毒包括但不限于HIV，HSV，CMV，HBV，HCV和流感病毒。
• Antimicrobial and Antiviral Compounds and Methods for their Use
  申请人：Dale M.K. Roderic

  公开号：US20070053971A1

  公开（公告）日：2007-03-08

  The present invention provides protonated compounds having antiviral and antimicrobial activity. The invention also provides antimicrobial compositions comprising protonated compounds of the invention. The protonated compounds of the invention provide efficacious antimicrobial activity against resistant strains of bacteria and opportunistic fungi. The invention also provides antiviral compositions comprising compounds of the invention. Viruses that may be treated by compositions of the invention include, but are not limited to, HIV, HSV, CMV, HBV, HCV and influenza virus.

  本发明提供了具有抗病毒和抗微生物活性的质子化化合物。本发明还提供了包含本发明的质子化合物的抗微生物组合物。本发明的质子化合物对耐药菌株和机会性真菌提供了有效的抗微生物活性。本发明还提供了包括本发明化合物的抗病毒组合物。本发明的组合物可以治疗的病毒包括但不限于HIV、HSV、CMV、HBV、HCV和流感病毒。
• Antimicrobial compounds, compositions, and uses thereof
  申请人：Lakewood Amedex, Inc.

  公开号：US11377468B2

  公开（公告）日：2022-07-05

  A method of treating an infection of at least one of a wound or a ulcer in a patient in need thereof according to an embodiment includes administering to the patient an effective amount of a compound having the formula: or a pharmaceutically acceptable salt thereof.

  根据一个实施方案，治疗有需要的患者伤口或溃疡中至少一种感染的方法包括向患者施用有效量的式化合物： 或其药学上可接受的盐。
• ANTIMICROBIAL AND ANTIVIRAL COMPOUNDS AND METHODS FOR THEIR USE
  申请人：Oligos Etc. Inc.

  公开号：EP2079313A2

  公开（公告）日：2009-07-22
• ANTIMICROBIAL COMPOUNDS, COMPOSITIONS, AND USES THEREOF
  申请人：Lakewood Amedex, Inc.

  公开号：US20210238215A1

  公开（公告）日：2021-08-05

  A method of treating an infection of at least one of a wound or a ulcer in a patient in need thereof according to an embodiment includes administering to the patient an effective amount of a compound having the formula: or a pharmaceutically acceptable salt thereof.