2-(4-Amino-2,3,5,6-tetramethylphenoxy)-N-methyl-N-{1-[2-(N-methylanilino)-2-oxoethyl]-4-piperidinyl}acetamide | 760936-93-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-Amino-2,3,5,6-tetramethylphenoxy)-N-methyl-N-{1-[2-(N-methylanilino)-2-oxoethyl]-4-piperidinyl}acetamide
• 英文别名: 2-[4-[[2-(4-amino-2,3,5,6-tetramethylphenoxy)acetyl]-methylamino]piperidin-1-yl]-N-methyl-N-phenylacetamide
• CAS: 760936-93-4
• 化学式: C₂₇H₃₈N₄O₃
• 分子量: 466.624
• InChiKey: VXISLODNDOWMDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  79.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(4-Amino-2,3,5,6-tetramethylphenoxy)-N-methyl-N-(4-piperidinyl)acetamide 、 N-methyl-N-phentyl-2-bromoacetamide 生成 2-(4-Amino-2,3,5,6-tetramethylphenoxy)-N-methyl-N-{1-[2-(N-methylanilino)-2-oxoethyl]-4-piperidinyl}acetamide
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Aminophenoxyacetamide derivatives and pharmaceutical composition containing thereof
  申请人：——

  公开号：US20030139447A1

  公开（公告）日：2003-07-24

  There is provided an aminophenoxyacetamide derivative of the formula (I): wherein, R 1 to R 4 are, independent from each other, hydrogen atom; optionally substituted alkyl group; E 1 is —NR 4 — and E 2 is oxygen atom or —NR 10 ; Q is group —X—Y—Q′ (X and Y are connecting bond; X is alkylene or alkenylene group, etc.; Y is selected from the groups consisting of C═O, NHC(═O), C(═O)NH, etc.; Q′ is hydrogen atom or pheny, pyridyl groups which may be substituted, etc.), or a pharmaceutically acceptable salt thereof. These compounds have neuroprotective effect by introducing the CalbindinD-28k, one of Ca 2+ -binding proteins. 11

  提供了一种氨基苯氧乙酰胺衍生物，其化学式为(I)：其中，R1至R4独立地为氢原子；可选择取代的烷基基团；E1为—NR4—，E2为氧原子或—NR10；Q为基团—X—Y—Q′（X和Y为连接键；X为烷基或烯基基团等；Y选自由C═O、NHC(═O)、C(═O)NH等组成的基团；Q′为氢原子或苯基、可取代的吡啶基团等），或其药学上可接受的盐。这些化合物通过引入钙结合蛋白之一的CalbindinD-28k具有神经保护作用。
• AMINOPHENOXYACETAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
  申请人：Asubio Pharma Co., Ltd.

  公开号：EP1228367B1

  公开（公告）日：2007-09-26
• US7067533B2
  申请人：——

  公开号：US7067533B2

  公开（公告）日：2006-06-27
• [EN] AMINOPHENOXYACETAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF<br/>[FR] DERIVES D'AMINOPHENOXYACETAMIDE ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：SUNTORY LTD

  公开号：WO2001079170A2

  公开（公告）日：2001-10-25

  There is provided an aminophenoxyacetamide derivative of the formula (I): wherein, R1 to R4 are, independent from each other, hydrogen atom; optionally substituted alkyl group; E?1 is -NR4- and E2¿ is oxygen atom or -NR10; Q is group -X-Y-Q' (X and Y are connecting bond; X is alkylene or alkenylene group, etc.; Y is selected from the groups consisting of C=O, NHC(=O), C(=O)NH, etc.; Q' is hydrogen atom or pheny, pyridyl groups which may be substituted, etc.),or a pharmaceutically acceptable salt thereof.These compounds have neuroprotective effect by introducing the CalbindinD-28k, one of Ca2+-binding proteins.11