4-(5-chloro-2-phenyl-1H-indole-7-yl)amino-piperidine-1-yl-carboxylic acid phenylamide | 1120333-35-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-(5-chloro-2-phenyl-1H-indole-7-yl)amino-piperidine-1-yl-carboxylic acid phenylamide
• 英文别名: 4-(5-chloro-2-phenyl-1H-indol-7-yl)amino-piperidin-1-yl-carboxylic acid phenylamide；4-[(5-chloro-2-phenyl-1H-indol-7-yl)amino]-N-phenylpiperidine-1-carboxamide
• CAS: 1120333-35-8
• 化学式: C₂₆H₂₅ClN₄O
• 分子量: 444.964
• InChiKey: RJSPUNTVEZUYKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  60.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (5-chloro-2-phenyl-1H-indole-7-yl)-piperidine-4-yl-amine 、 异氰酸苯酯 生成 4-(5-chloro-2-phenyl-1H-indole-7-yl)amino-piperidine-1-yl-carboxylic acid phenylamide
  参考文献：
  名称：

  Indole and indazole compounds as an inhibitor of cellular necrosis

  摘要：

  本发明涉及吲哚或吲唑化合物，其药学上可接受的盐或异构体，用于预防或治疗细胞坏死和与坏死相关的疾病。本发明还涉及一种预防或治疗细胞坏死和与坏死相关的疾病的方法和组合物，其包括所述吲哚或吲唑化合物作为活性成分。

  公开号：

  US08436038B2

文献信息

• INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS
  申请人：Kim Soon Ha

  公开号：US20100197673A1

  公开（公告）日：2010-08-05

  The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

  本发明涉及吲哚或吲唑化合物，其药学上可接受的盐或异构体，用于预防或治疗细胞坏死和与坏死相关的疾病。本发明还涉及一种用于预防或治疗细胞坏死和与坏死相关疾病的方法和组合物，包括所述吲哚或吲唑化合物作为活性成分。
• [EN] INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS<br/>[FR] COMPOSÉS D'INDOLE ET D'INDAZOLE EN TANT QU'INHIBITEURS DE NÉCROSE CELLULAIRE
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2009025478A1

  公开（公告）日：2009-02-26

  The present invention relates to indole or indazole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole or indazole compounds as an active ingredient.

  本发明涉及吲哚或吲唑化合物，其药用盐或异构体，可用于预防或治疗细胞坏死和与坏死相关的疾病。本发明还涉及一种用于预防或治疗细胞坏死和与坏死相关疾病的方法和组合物，包括所述吲哚或吲唑化合物作为活性成分。
• Benzamides Useful as S1P Receptor Modulators
  申请人：Mattes Henri

  公开号：US20100197753A1

  公开（公告）日：2010-08-05

  The invention relates to novel aromatic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, b their use as medicaments and to medicaments comprising them.

  本发明涉及新的芳香化合物，其公式为，在该公式中所有的变量如规范中定义，以自由形式或盐形式存在，涉及它们的制备方法，它们作为药物的用途以及包含它们的药物。
• PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING OPHTHALMIC DISORDERS
  申请人：CATHOLIC UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US20150038500A1

  公开（公告）日：2015-02-05

  The invention relates to a pharmaceutical composition for preventing or treating an ophthalmologic disease comprising a compound of formula (1) as defined in the specification, or a pharmaceutically acceptable salt or isomer thereof as an active ingredient. Also, the invention relates to a composition for cleansing or preserving a contact lens comprising the above active ingredient.
• US8436038B2
  申请人：——

  公开号：US8436038B2

  公开（公告）日：2013-05-07