(6-Bromo-7-methoxy-1,3-benzodioxol-5-yl)methoxy-tri(propan-2-yl)silane | 1044800-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: (6-Bromo-7-methoxy-1,3-benzodioxol-5-yl)methoxy-tri(propan-2-yl)silane
• CAS: 1044800-98-7
• 化学式: C₁₈H₂₉BrO₄Si
• 分子量: 417.415
• InChiKey: AQNZWYFCOZGZIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.88
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (6-Bromo-7-methoxy-1,3-benzodioxol-5-yl)methoxy-tri(propan-2-yl)silane 、 (S)-4-Isopropyl-2-(2,3,4,5-tetramethoxy-phenyl)-4,5-dihydro-oxazole 在 magnesium 、 1,2-二溴乙烷 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Catalyzed Cyclizations Leading to Enrichment of Functionality and Chirality. A General Approach to Dibenzocyclooctadiene Lignans from α,ω-Diynes

  摘要：

  The [B-Sn]-mediated cyclization of alpha,omega-diynes results in not only an increase in the functionalizable groups (incorporated as highly versatile vinyl-B and vinyl-Sn groups) but also an increase in new serviceable stereochemical elements. The alkylidene functionalities at C-7 and C-8 offer unprecedented opportunities for the synthesis of highly functionalized dibenzocyclooctadienes. Examples of interiotherins and gomisins are provided.

  DOI：

  10.1021/ol8013792

文献信息

• Catalyzed Cyclizations Leading to Enrichment of Functionality and Chirality. A General Approach to Dibenzocyclooctadiene Lignans from α,ω-Diynes
  作者：Ramakrishna Reddy Singidi、T. V. RajanBabu

  DOI：10.1021/ol8013792

  日期：2008.8.7

  The [B-Sn]-mediated cyclization of alpha,omega-diynes results in not only an increase in the functionalizable groups (incorporated as highly versatile vinyl-B and vinyl-Sn groups) but also an increase in new serviceable stereochemical elements. The alkylidene functionalities at C-7 and C-8 offer unprecedented opportunities for the synthesis of highly functionalized dibenzocyclooctadienes. Examples of interiotherins and gomisins are provided.