(3,4-Difluorophenoxy)-acetaldehyde | 342435-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3,4-Difluorophenoxy)-acetaldehyde
• 英文别名: 2-(3,4-Difluorophenoxy)acetaldehyde
• CAS: 342435-27-2
• 化学式: C₈H₆F₂O₂
• 分子量: 172.131
• InChiKey: RNQLPHHLLJDRTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(2,2-dimethoxyethoxy)-1,2-difluorobenzene 在 硫酸 、 水 作用下， 以 溶剂黄146 为溶剂， 反应 5.0h， 以68%的产率得到(3,4-Difluorophenoxy)-acetaldehyde
  参考文献：
  名称：

  IMIDAZOLE DERIVATIVES AND THEIR USE AS RAF KINASE INHIBITORS

  摘要：

  公开号：

  EP1232153B1

文献信息

• Compounds
  申请人：SmithKline Beecham p.l.c.

  公开号：US07026336B1

  公开（公告）日：2006-04-11

  Compounds of formula (I) wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; Y is NR10R11, NR10C(Z)NR10R11, NR10COOR11 or NR10SO2R11; Ar is phenyl or a 5- or 6-membered heteroaryl ring either of which may be optionally substituted; n is 0, 1, 2, 3 or 4; and R1, R2, R3, R4, R10 and R11 have the meanings given in the description; and pharmaceutically acceptable salt thereof.

  化合物的公式（I），其中X为O，CH2，S或NH，或者X-R1基团为氢；V为CH或N；Y为NR10R11，NR10C（Z）NR10R11，NR10COOR11或NR10SO2R11；Ar为苯基或5或6成员的杂环，其中任何一个都可以选择性地被取代；n为0，1，2，3或4；R1，R2，R3，R4，R10和R11具有描述中给出的含义；以及其药学上可接受的盐。
• Bi-functional complexes and methods for making and using such complexes
  申请人：Gouliaev Alex Haahr

  公开号：US11225655B2

  公开（公告）日：2022-01-18

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

  本发明涉及一种合成双功能复合物的方法，该复合物包括分子部分和识别分子部分的识别寡核苷酸部分。根据本发明的合成方法的一部分优选在一种或多种有机溶剂中进行，此时包含可选保护标签或寡核苷酸标识符的新生双功能复合物与固体支持物相连接，合成方法的另一部分优选在适合于将寡核苷酸标签酶加到溶液中的新生双功能复合物的条件下进行。
• BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Nuevolution A/S

  公开号：EP2558577A1

  公开（公告）日：2013-02-20
• BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES
  申请人：Gouliaev Alex Haahr

  公开号：US20130281324A1

  公开（公告）日：2013-10-24

  The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
• US7026336B1
  申请人：——

  公开号：US7026336B1

  公开（公告）日：2006-04-11