2-Dimethylamino-6-fluorbenzamid | 107485-44-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Dimethylamino-6-fluorbenzamid
• 英文别名: 2-(Dimethylamino)-6-fluorobenzamide
• CAS: 107485-44-9
• 化学式: C₉H₁₁FN₂O
• 分子量: 182.198
• InChiKey: OOCPQLDZKZSIEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Dimethylamino-6-fluorbenzamid 、 对氯苯异氰酸酯 生成 克兰氟脲
  参考文献：
  名称：

  J. Agr. Food Chem. 1973, 21, 993-998

  摘要：

  DOI：

文献信息

• Method of treating haematologic diseases and pharmaceutical compositions to be used therefor
  申请人：DUPHAR INTERNATIONAL RESEARCH B.V

  公开号：EP0324521A2

  公开（公告）日：1989-07-19

  The present invention relates to a method of treating hematopoietic diseases in a warm-blooded living being by administration of a composition comprising at least one compound of the general formula wherein R₁ is a phenyl group, a C₁-C₁₆ alkyl group, a C₆-C₁₂ (bridged) cycloalkyl group, a cyclohexadienyl group, a styryl group, a phenyl(C₁-C₄)alkyl group, an N-oxypyridyl group or a heteroaryl group having 1 or 2 nitrogen atoms in its nucleus, which groups may be substituted with one or more substituents selected from the group consisting of halogen, C₁-C₆ alkyl, C₁-C₄ haloalkyl, C₁-C₄ alkoxy, C₁-C₄ haloalkoxy, C₁-C₄ alkylthio, C₁-C₄ haloalkylthio, nitro, hydroxy, C₁-C₅ alkanoyloxy and amino, which amino group may be substituted with a C₂-C₅ alkanoyl group or with 1 or 2 C₁-C₄ alkyl groups which, together with the amino N, may form a heterocyclic ring; X is an oxygen atom or a sulphur atom; R₃ is a hydrogen atom, a C₁-C₄ alkyl group or a C₂-C₅ alkoxyalkyl group; Y is an oxygen atom or a sulphur atom; R₄ is a hydrogen atom or a C₁-C₄ alkyl group; n is 0 or 1; and R₂ is a hydrogen atom, a C₁-C₆ alkyl group, a phenyl group, a C₆-C₁₂ (bridged) cycloalkyl group, a phenyl(C₁-C₄)alkyl group or a heterocyclic group having 1-3 hetero atoms selected from N, O and S in its nucleus, which phenyl group, cycloalkyl group, phenylalkyl group and heterocyclic group may be substituted with one or more substituents selected from the group consisting of halogen, C₁-C₆ alkyl, C₁-C₄ haloalkyl, C₁-C₄ alkoxy, a C₁-C₄ haloalkoxy, C₁-C₄ alkylthio, C₁-C₄ haloalkylthio, C₁-C₄ alkylsulphinyl, C₁-C₄ haloalkylsulphinyl, C₁-C₄ alkylsulphonyl, C₁-C₄ haloalkylsulphonyl, optionally substituted C₃-C₁₂ cycloalkyl, optionally substituted C₃-C₁₂ cycloalkoxy, nitro, hydroxy, cyano, C₂-C₅ alkylcarbonyl, C₂-C₅ alkoxycarbonyl, optionally substituted benzoyl, optionally substituted phenoxy, optionally substituted phenyl(C₁-C₄)alkoxy, optionally substituted heteroaryloxy having 1 or 2 heteroatoms in its aromatic nucleus selected from N, O and S, and amino, which amino group may be substituted with a C₂-C₅ alkanoyl group or with 1 or 2 C₁-C₄ alkyl groups which, together with the amino N, may form a heterocyclic ring, which ring may comprise an additional N and may be substituted in its turn; or wherein two of the said substituents together constitute a C₁-C₃ alkylenedioxy group or haloalkylenedioxy group.

  本发明涉及一种通过施用包含至少一种通式化合物的组合物来治疗温血动物造血疾病的方法。 其中 R₁ 是苯基、C₁-C₁₆ 烷基、C₆-C₁₂ (桥联)环烷基、环己二烯基、苯乙烯基、苯基(C₁-C₄)烷基、N-oxypyridyl 基团或在其原子核中有 1 或 2 个氮原子的杂芳基，这些基团可被一个或多个选自卤素的取代基取代、C₁-C₆ 烷基、C₁-C₄ 卤代烷基、C₁-C₄ 烷氧基、C₁-C₄ 卤代烷氧基、C₁-C₄ 烷硫基、C₁-C₄ 卤代烷硫基、硝基、羟基、C₁-C₅ 烷酰氧基和氨基、其中氨基可被 C₂-C₅ 烷酰基或 1 或 2 个 C₁-C₄ 烷基取代，这些基团与氨基 N 可形成杂环； X 是氧原子或硫原子； R₃ 是氢原子、C₁-C₄ 烷基或 C₂-C₅ 烷氧基烷基； Y 是氧原子或硫原子； R₄ 是氢原子或 C₁-C₄ 烷基； n 是 0 或 1；以及 R₂是氢原子、C₁-C₆烷基、苯基、C₆-C₁₂(桥联)环烷基、苯基(C₁-C₄)烷基或在其核中具有 1-3 个选自 N、O 和 S 的杂原子的杂环基团，其中苯基、环烷基、苯基烷基和杂环基都是氢原子、C₁-C₄烷基、苯基(C₁-C₄)烷基和杂环基、苯基、环烷基、苯基烷基和杂环基团可被一个或多个取代基取代，取代基可选 自卤素、C₁-C₆ 烷基、C₁-C₄ 卤代烷基、C₁-C₄ 烷氧基组成的组、C₁-C₄卤代烷氧基、C₁-C₄烷硫基、C₁-C₄卤代烷硫基、C₁-C₄烷基亚磺酰基、C₁-C₄卤代烷基亚磺酰基、C₁-C₄烷基磺酰基、C₁-C₄卤代烷基磺酰基、任选取代的 C₃-C₁₂ 环烷基、任选取代的 C₃-C₁₂ 环烷氧基、硝基、羟基、氰基、C₂-C₅ 烷羰基、C₂-C₅烷氧羰基、任选取代的苯甲酰基、任选取代的苯氧基、任选取代的苯基（C₁-C₄）烷氧基、任选取代的杂芳基氧基，其芳香核中有 1 或 2 个选自 N、O 和 S 的杂原子，以及氨基，该氨基可被 C₂-C₅ 烷酰基或 1 或 2 个 C₁-C₄ 烷基取代，该烷基与氨基 N 可形成杂环，该环可包括一个额外的 N 并可依次被取代； 或其中两个取代基共同构成 C₁-C₃ 烷二氧基或卤代烷二氧基。
• J. Agr. Food Chem. 1973, 21, 993-998
  作者：

  DOI：——

  日期：——