ethyl 2-hydroxy-3-isopropyl-5-oxo-2H,3H,5H-thiazolo<3,2-a>pyridine-8-carboxylate | 145904-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: ethyl 2-hydroxy-3-isopropyl-5-oxo-2H,3H,5H-thiazolo<3,2-a>pyridine-8-carboxylate
• 英文别名: Ethyl 2-hydroxy-5-oxo-3-propan-2-yl-2,3-dihydro-[1,3]thiazolo[3,2-a]pyridine-8-carboxylate
• CAS: 145904-30-9
• 化学式: C₁₃H₁₇NO₄S
• 分子量: 283.348
• InChiKey: FSMDAQHKRUPQTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  92.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  diethyl 2-isopropenyl-4-oxo-1-thia-3-azabicyclo<4.2.0>octa-5,7-diene-2,7-dicarboxylate 在 platinum(IV) oxide sodium tetrahydroborate 、 氢气 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 3.0h， 生成 ethyl 2-hydroxy-3-isopropyl-5-oxo-2H,3H,5H-thiazolo<3,2-a>pyridine-8-carboxylate
  参考文献：
  名称：

  Reductive and catalytic rearrangements of 2-vinyl-1,3-thiazetidines

  摘要：

  2-Vinyl-1,3-thiazetidines have been shown to undergo a novel rearrangement to give thiazolidines such as 3 in good yield on hydrogenation using heterogeneous catalysts. When homogeneous catalysts are used, rearrangement takes a different course and thiazines such as 1 are formed. Borohydride reduction yields thiolactols such as 20.

  DOI：

  10.1016/s0040-4020(01)89044-x

文献信息

• Reductive and catalytic rearrangements of 2-vinyl-1,3-thiazetidines
  作者：Nigel K Capps、Gareth M Davies、David Loakes、Douglas W Young

  DOI：10.1016/s0040-4020(01)89044-x

  日期：——

  2-Vinyl-1,3-thiazetidines have been shown to undergo a novel rearrangement to give thiazolidines such as 3 in good yield on hydrogenation using heterogeneous catalysts. When homogeneous catalysts are used, rearrangement takes a different course and thiazines such as 1 are formed. Borohydride reduction yields thiolactols such as 20.