1,4-bis(4-methyl-phenylamino)-6-carboxy-anthraquinone | 853022-33-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 1,4-bis(4-methyl-phenylamino)-6-carboxy-anthraquinone
• 英文别名: 5,8-bis(4-methylanilino)-9,10-dioxoanthracene-2-carboxylic acid
• CAS: 853022-33-0
• 化学式: C₂₉H₂₂N₂O₄
• 分子量: 462.505
• InChiKey: IOCHVQUKLRTZFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,4-Dihydroxy-2,3-dihydro-6-carboxy-anthraquinone 、 乙烷,三氯氟- 在 硼酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 戊醇 、 水 为溶剂， 生成 1,4-bis(4-methyl-phenylamino)-6-carboxy-anthraquinone
  参考文献：
  名称：

  Quencher compositions comprising anthraquinone moieties

  摘要：

  本发明提供了一种新型猝灭剂组合物，包括蒽醌猝灭剂基团。当连接到生物分子（如天然或改性多聚核苷酸、寡核苷酸、核苷、核苷酸、碳水化合物和肽）时，蒽醌猝灭剂基团可用作猝灭剂标记。例如，多聚核苷酸可在3'端标记荧光猝灭剂固相支持组合物，也可在内部或5'端标记多聚核苷酸。可检测的探针可能具有类似分子信标、蝎子探针、日出探针、构象辅助探针和TaqMan探针的格式。

  公开号：

  US20050227254A1

文献信息

• Novel methods for quantification of microRNAs and small interfering RNAs
  申请人：Jacobsen Nana

  公开号：US20050272075A1

  公开（公告）日：2005-12-08

  The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.

  本发明涉及核糖核酸、探针和检测、定量以及监测成熟微小RNA和小干扰RNA（siRNA）表达的方法。此外，本发明还涉及监测其他非编码RNA、mRNA剪接变体的表达，以及检测和定量RNA编辑、单个转录本的等位变体、突变、缺失或重复特定外显子的方法，例如与人类疾病如癌症相关的改变。此外，本发明还涉及检测、定量以及监测脱氧核糖核酸的表达的方法。
• Probes, libraries and kits for analysis of mixtures of nucleic acids and methods for constructing the same
  申请人：Ramsing Birger Niels

  公开号：US20060166238A1

  公开（公告）日：2006-07-27

  The invention relates to nucleic acid probes, nucleic acid probe libraries, and kits for detecting, classifying, or quantifying components in a complex mixture of nucleic acids, such as a transcriptome, and methods of using the same. The invention also relates to methods of identifying nucleic acid probes useful in the probe libraries and to methods of identifying a means for detection of a given nucleic acid.

  本发明涉及核酸探针、核酸探针库和用于检测、分类或定量核酸复杂混合物（例如转录组）中的组分的工具箱以及使用它们的方法。本发明还涉及识别有用于探针库的核酸探针的方法，以及识别给定核酸检测手段的方法。
• NOVEL METHODS FOR QUANTIFICATION OF MICRORNAS AND SMALL INTERFERING RNAS
  申请人：Jacobsen Nana

  公开号：US20110076675A1

  公开（公告）日：2011-03-31

  The invention relates to ribonucleic acids, probes and methods for detection, quantification as well as monitoring the expression of mature microRNAs and small interfering RNAs (siRNAs). The invention furthermore relates to methods for monitoring the expression of other non-coding RNAs, mRNA splice variants, as well as detecting and quantifying RNA editing, allelic variants of single transcripts, mutations, deletions, or duplications of particular exons in transcripts, e.g., alterations associated with human disease such as cancer. The invention furthermore relates to methods for detection, quantification as well as monitoring the expression of deoxy nucleic acids.

  本发明涉及到核糖核酸、探针和方法，用于检测、定量以及监测成熟微小RNA和小干扰RNA（siRNA）的表达。此外，本发明还涉及监测其他非编码RNA、mRNA剪接变体的表达，以及检测和定量RNA编辑、单个转录本的等位变体、突变、缺失或转录本中特定外显子的重复等，例如与人类疾病（如癌症）相关的变化。此外，本发明还涉及检测、定量以及监测脱氧核糖核酸的表达方法。
• Quencher composition comprising anthraquinone moieties
  申请人：Exiqon A/S

  公开号：EP1538154A1

  公开（公告）日：2005-06-08

  The present invention provides novel quencher composition comprising anthraquinone quencher moieties. The anthraquinone quencher moieties are useful as quencher labels when attached to biomolecules such as natural or modified polynucleotides, oligonucleotides, nucleosides, nucleotides, carbohydrates and peptides. For example, polynucleotides can be labeled at the 3' terminus with fluorescence quencher solid support compositions, and polynucleotides can be labeled at internally or at the 5' terminus. The detectable probes may have a format like molecular beacons, scorpion probes, sunrise probes, conformationally assisted probes and TaqMan probes.

  本发明提供了包含蒽醌淬灭剂分子的新型淬灭剂组合物。当蒽醌淬灭剂分子连接到生物大分子，如天然或修饰的多核苷酸、寡核苷酸、核苷酸、核苷酸、碳水化合物和肽时，可用作淬灭剂标签。例如，可以用荧光淬灭剂固体支持物组合物在多核苷酸的 3'末端进行标记，也可以在多核苷酸的内部或 5'末端进行标记。可检测探针的形式可以是分子信标、蝎子探针、日出探针、构象辅助探针和 TaqMan 探针。
• METHODS FOR QUANTIFICATION OF MICRORNAS AND SMALL INTERFERING RNAS
  申请人：Exiqon A/S

  公开号：EP1735459B1

  公开（公告）日：2012-01-25