4-hydroxy-6-isopropylpyridazin-3(2H)-one | 1616378-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-hydroxy-6-isopropylpyridazin-3(2H)-one
• 英文别名: 4-hydroxy-6-isopropylpyridazine-3(2H)-one；6-Propan-2-yl-1,2-dihydropyridazine-3,4-dione
• CAS: 1616378-79-0
• 化学式: C₇H₁₀N₂O₂
• 分子量: 154.169
• InChiKey: UPNFCKKKLKWKBP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-bis(benzyloxy)-6-(prop-1-en-2-yl)pyridazine 在 palladium on activated charcoal 、 氢气 作用下， 以 乙醇 为溶剂， 生成 4-hydroxy-6-isopropylpyridazin-3(2H)-one
  参考文献：
  名称：

  [EN] PYRIDAZINONES AS DAAO ENZYME INHIBITORS
  [FR] PYRIDAZINONES À TITRE D'INHIBITEURS D'ENZYMES DAAO

  摘要：

  本发明提供了化合物(I)及其药用可接受的盐，其中R1和R2如规范中定义，以及它们的制备方法，含有它们的药物组合物以及它们在治疗中的用途。

  公开号：

  WO2014096757A1

文献信息

• CEPHEM COMPOUND HAVING PYRIDINIUM GROUP
  申请人：Nishitani Yasuhiro

  公开号：US20140114060A1

  公开（公告）日：2014-04-24

  The present invention provides a novel compound which has a broad antibacterial spectrum and particularly exhibits a high antibacterial activity on β-lactamase-producing gram-negative bacteria. Specifically provided are: a compound represented by formula (I) wherein the meaning of each symbol is as defined in the description, an amino-group-protected form of a type of the compound which has the amino group on a ring in a position-7 side chain, or a pharmaceutically acceptable salt of the compound or the amino-group-protected form; and a pharmaceutical composition containing the compound, the amino-group-protected form or the pharmaceutically acceptable salt.

  本发明提供了一种新型化合物，具有广泛的抗菌谱，特别对产β-内酰胺酶的革兰氏阴性细菌表现出高抗菌活性。具体提供的是：一种由式(I)表示的化合物，其中每个符号的含义如描述中定义的那样，一种在环上具有氨基团的化合物的保护形式，该化合物在位置-7侧链上具有氨基团，或者化合物或氨基团保护形式的药用可接受盐；以及含有该化合物、氨基团保护形式或药用可接受盐的药物组合物。
• CEPHEM COMPOUND HAVING PSEUDO-CATECHOL GROUP
  申请人：Yamawaki Kenji

  公开号：US20130079319A1

  公开（公告）日：2013-03-28

  A compound of the formula: wherein X is —N═, —CH═, or the like; W is —CH 2 — or the like; U is —S— or the like; R 1 and R 2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; Q is a single bond or the like; R 3 is hydrogen or the like; Ring A is a 6-membered aromatic heterocyclic group having 1-3 nitrogen atoms; each R 4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; G is —C(═O)— or the like; D is a single bond, —NH—, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.

  该化合物的化学式为：其中X为—N═、—CH═或类似基团；W为—CH2—或类似基团；U为—S—或类似基团；R1和R2各自独立地为氢、卤素、选择性取代的低碳基或类似基团；Q为单键或类似键；R3为氢或类似基团；环A为一个6元芳香杂环基团，具有1-3个氮原子；每个R4独立地为氢、卤素或类似基团；m为0到2的整数；G为—C(═O)—或类似基团；D为单键、—NH—或类似基团；E为一个环状季铵基团，或者是在7侧链上的氨基处的酯、保护化合物、药学上可接受的盐或其溶剂化物。
• PYRIDAZINONES AS DAAO ENZYME INHIBITORS
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20150329495A1

  公开（公告）日：2015-11-19

  The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R 1 and R 2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明提供式（I）的化合物及其药学上可接受的盐，其中R1和R2如规范中所定义，其制备过程，包含它们的制药组合物以及它们在治疗中的使用。
• 2-SUBSTITUTED CEPHEM COMPOUNDS
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299223A1

  公开（公告）日：2015-10-22

  The present invention relates to 2-substituted cephem compounds of Formula (I) having a quaternary ammonium group on the 3-side chain, preferably together with a cathechol group, or pharmaceutically acceptable salts thereof, which exhibit potent antimicrobial spectrum against a variety of bacteria including Gram negative bacteria and/or Gram positive bacteria, corresponding pharmaceutical compositions, methods of making, treatment methods for bacterial infections or uses thereof.

  本发明涉及具有第3侧链上季铵基团的2-取代头孢菌素化合物（I）, 与儿茶酚基团一起更佳，或其药学上可接受的盐，对包括革兰氏阴性菌和/或革兰氏阳性菌在内的多种细菌具有强效的抗微生物谱，相应的制药组合物，制备方法，治疗细菌感染的方法或其用途。
• 2 substituted cephem compounds
  申请人：Glaxo Group Limited

  公开号：US10174053B2

  公开（公告）日：2019-01-08

  The compounds of the subject invention are related to 2-substituted cephem compounds, which have a wide antimicrobial spectrum, in particular exhibit potent antimicrobial activity against beta-lactamase producing Gram negative bacteria, and pharmaceutical compositions comprising the same.

  本发明的化合物与 2-取代的头孢化合物有关，它们具有广泛的抗菌谱，特别是对β-内酰胺酶产生的革兰氏阴性菌具有强效抗菌活性，以及包含这些化合物的药物组合物。