2-Allyl-1-allyloxy-4-benzyloxy-benzene | 205433-79-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-Allyl-1-allyloxy-4-benzyloxy-benzene
• 英文别名: 4-phenylmethoxy-1-prop-2-enoxy-2-prop-2-enylbenzene
• CAS: 205433-79-0
• 化学式: C₁₉H₂₀O₂
• 分子量: 280.367
• InChiKey: MZGOFTOKOGRXPJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Allyl-1-allyloxy-4-benzyloxy-benzene 反应 14.0h， 以77%的产率得到2,6-Diallyl-4-benzyloxy-phenol
  参考文献：
  名称：

  Photochemistry of Substituted 4,4-Dimethoxy-2,5-Cyclohexadienones

  摘要：

  Abstract4,4‐Dimethoxy‐2,5‐cyclohexadienones 9–14 were prepared from the corresponding hydroquinone monomethyl ethers by oxidation with thallium trinitrate in methanol. Irradiation of solutions of 9–13 in methanol with a broad band of UV light centered at 350 nm in a Rayonet reactor afforded 2‐cyclopentenone derivatives 15–19 in moderate to excellent yields, whereas irradiation of 14 in methanol gave phenol 8 along with other unidentified products. Irradiation of 11–14 in benzene yielded substituted phenols. The plausible reaction pathways for the product formation are discussed.

  DOI：

  10.1002/jccs.199800001
• 作为产物：
  描述：

  3-溴丙烯 、 2-丙烯基-4-苄氧基苯酚 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 反应 20.0h， 以96%的产率得到2-Allyl-1-allyloxy-4-benzyloxy-benzene
  参考文献：
  名称：

  Photochemistry of Substituted 4,4-Dimethoxy-2,5-Cyclohexadienones

  摘要：

  Abstract4,4‐Dimethoxy‐2,5‐cyclohexadienones 9–14 were prepared from the corresponding hydroquinone monomethyl ethers by oxidation with thallium trinitrate in methanol. Irradiation of solutions of 9–13 in methanol with a broad band of UV light centered at 350 nm in a Rayonet reactor afforded 2‐cyclopentenone derivatives 15–19 in moderate to excellent yields, whereas irradiation of 14 in methanol gave phenol 8 along with other unidentified products. Irradiation of 11–14 in benzene yielded substituted phenols. The plausible reaction pathways for the product formation are discussed.

  DOI：

  10.1002/jccs.199800001

文献信息

• Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists
  申请人：——

  公开号：US20040024034A1

  公开（公告）日：2004-02-05

  Compounds represented by the following (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H, alkyl or haloalkyl, the polymethylene chain (II), is saturated or may contain a carbon-carbon double bond, while n is 2, 3, 4, W is O or S, Y is an unsubsituted or substituted phenylene, naphthylene or 1, 2, 3, 4 tetrahydronaphthylene, R3 is H, alkyl or haloalkyl. R4 is H, alkyl, haloalkyl or a substituted or unsubstituted benzyl, are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.

  以下化合物（I）及其药用可接受的盐、溶剂化合物和水合物，其中R1是未取代或取代的芳基、杂环芳基、环烷基、芳基-烷基、杂环芳基-烷基或环烷基-烷基，R2是H、烷基或卤代烷基，聚亚甲基链（II）饱和或可能含有碳-碳双键，n为2、3、4，W为O或S，Y是未取代或取代的苯基、萘基或1,2,3,4-四氢萘基，R3是H、烷基或卤代烷基。R4是H、烷基、卤代烷基或取代或未取代的苄基，用于调节过氧化物酶体增殖物激活受体，特别是在糖尿病治疗中是有用的。
• Oxazolyl-aryloxyacetic acid derivatives and their use as PPAR agonists
  申请人：Brooks Alisa Dawn

  公开号：US20050250825A1

  公开（公告）日：2005-11-10

  Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H, alkyl or haloalkyl, the polymethylene chain (H), is saturated or may contain a carbon-carbon double bond, while n is 2, 3, 4, W is O or S, Y is an unsubstituted phenylene, naphthylene or 1, 2, 3, 4 tetrahydronaphthylene, R3 is H, alkyl or haloalkyl, R4 is H, alkyl, haloalkyl or a substituted or unsubstituted benzyl, are useful for modulating a peroxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.

  以下结构式（I）所代表的化合物及其药学上可接受的盐、溶剂化合物和水合物，其中R1是未取代或取代的芳基、杂环芳基、环烷基、芳基-烷基、杂环芳基-烷基或环烷基-烷基，R2是氢、烷基或卤代烷基，聚亚甲基链（H）是饱和的或可能含有碳-碳双键，而n为2、3、4，W为O或S，Y为未取代的苯基、萘基或1、2、3、4-四氢萘基，R3是氢、烷基或卤代烷基，R4是氢、烷基、卤代烷基或取代或未取代的苄基，可用于调节过氧化物酶体增殖物激活受体，特别是用于治疗糖尿病。
• OXAZOLYL-ARYLOXYACETIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS
  申请人：Brooks Dawn Alisa

  公开号：US20080146631A1

  公开（公告）日：2008-06-19

  Compounds represented by the following structural formula (I), and pharmaceutically acceptable salts, solvates and hydrates thereof, wherein R1 is an unsubstituted or substituted aryl, heteroaryl, cycloalkyl, aryl-alkyl, heteroaryl-alkyl or cycloalkyl-alkyl, R2 is H, alkyl or haloalkyl, the polymethylene chain (II), is saturated or may contain a carbon-carbon double bond, while n is 2, 3, 4, W is O or S, Y is an unsubstituted or substituted phenylene, naphthylene or 1, 2, 3, 4 tetrahydronaphthylene, R3 is H, alkyl or haloalkyl, R4 is H, alkyl, haloalkyl or a substituted or unsubstituted benzyl, are useful for modulating a preoxisome proliferator activated receptor, particularly in the treatment of diabetes mellitus.

  以下结构式（I）所代表的化合物，以及其药学上可接受的盐、溶剂合物和水合物，其中R1为未取代或取代的芳基、杂环芳基、环烷基、芳基烷基、杂环芳基烷基或环烷基烷基，R2为H、烷基或卤代烷基，多亚甲基链（II）为饱和或含有碳-碳双键，n为2、3、4，W为O或S，Y为未取代或取代的苯基、萘基或1,2,3,4-四氢萘基，R3为H、烷基或卤代烷基，R4为H、烷基、卤代烷基或取代或未取代的苄基。这些化合物对于调节前线体增生激活受体特别是在糖尿病治疗中是有用的。
• US6982278B2
  申请人：——

  公开号：US6982278B2

  公开（公告）日：2006-01-03
• US7351728B2
  申请人：——

  公开号：US7351728B2

  公开（公告）日：2008-04-01