n-formyl-α,α-dimethyl-4-(phenylethynyl)-benzylamine | 54737-73-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: n-formyl-α,α-dimethyl-4-(phenylethynyl)-benzylamine
• 英文别名: N-Formyl-α,α-dimethyl-4-(phenylethinyl)-benzylamin；N-formyl-alpha,alpha-dimethyl-4-(phenylethynyl)-benzylamine；N-[2-[4-(2-phenylethynyl)phenyl]propan-2-yl]formamide
• CAS: 54737-73-4
• 化学式: C₁₈H₁₇NO
• 分子量: 263.339
• InChiKey: KHGXLWLOLJTXTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  n-formyl-α,α-dimethyl-4-(phenylethynyl)-benzylamine 在 盐酸 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 α,α-dimethyl-4-(phenylethynyl)-benzylamine hydrochloride
  参考文献：
  名称：

  Chemical compounds and the process for preparing same

  摘要：

  本申请公开了制备苯乙炔基芳基胺和苯乙炔基烷基胺的方法。将N-甲酰基碘苯基胺与金属苯乙炔基反应，随后还原或水解产生所需的苯乙炔基苯基胺。相应的苯乙烯基烷基胺由苯乙炔基苯基胺的催化氢化反应产生。

  公开号：

  US03957871A1
• 作为产物：
  描述：

  copper(I) phenylacetylenide 、 对碘苯甲酸乙酯 、 甲基溴化镁 、 氰化钠 生成 n-formyl-α,α-dimethyl-4-(phenylethynyl)-benzylamine
  参考文献：
  名称：

  Antiarrhythmic agents. 2-, 3-, and 4-Substituted benzylamines

  摘要：

  The synthesis of a series of 2-, 3-, and 4-substituted benzylamine derivatives is described. These compounds were studied for their effect on experimental cardiac arrhythmias. Many of the derivatives, but in particular 2-(p-methoxyphenylethynyl)benzylamine (3d), alpha,alpha-dimethyl-4y(phenylethynyl)benzylamine (7a), and alpha,alpha-dimethyl-4-phenethylbenzylamine (12g), showed good antiarrhythmic activity.

  DOI：

  10.1021/jm00236a006

文献信息

• Combination therapy
  申请人：——

  公开号：US20040102360A1

  公开（公告）日：2004-05-27

  The present invention relates to methods of treating cancer using a combination of at least two Akt inhibitors or a compound which is an inhibitor of Akt and an inhibitor of a protein kinase, which methods comprise administering to a mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound(s) which are inhibitors of Akt and compound(s) which are inhibitors of protein kinases. The invention also relates to methods of preparing such compositions.

  本发明涉及使用至少两种Akt抑制剂的组合或一种同时是Akt抑制剂和蛋白激酶抑制剂的化合物来治疗癌症的方法，该方法包括向哺乳动物施用来自以下组合中选择的至少两种治疗剂的量，该组合包括Akt抑制剂和蛋白激酶抑制剂。该发明还涉及制备这种组合物的方法。
• Method of treating cancer
  申请人：——

  公开号：US20040106540A1

  公开（公告）日：2004-06-03

  The present invention is directed to a method of treating cancer which comprises administration of a compound which selectively inhibits the activity of one or two of the isoforms of Akt, a serine/threonine protein kinase. The invention is particularly directed to the method wherein the compound is dependent on the presence of the plestrin homology domain of Akt for its inhibitory activity.

  本发明涉及一种治疗癌症的方法，包括给予一种选择性抑制一种或两种Akt异构体（一种丝氨酸/苏氨酸蛋白激酶）活性的化合物。本发明特别涉及一种方法，其中所述化合物的抑制活性依赖于Akt的plestrin同源结构域的存在。
• .alpha.,.alpha.-Dialkyl-4-phenethyl-benzylamines and the salts thereof
  申请人：Merck & Co., Inc.

  公开号：US04017543A1

  公开（公告）日：1977-04-12

  This application discloses methods of preparing .alpha.,.alpha.-diloweralkyl substituted benzylamines by the catalytic hydrogenation of the corresponding .alpha.,.alpha.-dialkyl-4-(phenyl-ethynyl)-benzylamine. The produced .alpha.,.alpha.-diloweralkylamines are converted to the corresponding N-alkyl and N,N-dialkyl derivatives thereof. The amines and their alkylated derivatives are useful as antiarrhythmics.

  这个申请公开了一种制备α，α-二低烷基取代苯基胺的方法，其通过对应的α，α-二烷基-4-（苯乙炔基）-苯基胺的催化氢化反应而制得。所产生的α，α-二低烷基胺转化为相应的N-烷基和N，N-二烷基衍生物。这些胺及其烷基化衍生物可用作抗心律失常药物。
• Inhibitors of akt activity
  申请人：——

  公开号：US20040143117A1

  公开（公告）日：2004-07-22

  The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.

  本发明涉及含有2,3-二苯基喹啉基团的化合物，其抑制Akt酶活性，一种丝氨酸/苏氨酸蛋白激酶。本发明进一步涉及含有本发明化合物的化疗组合物以及治疗癌症的方法，包括给予本发明化合物的给药。
• A METHOD OF TREATING CANCER
  申请人：Merck & Co., Inc.

  公开号：EP1379250A2

  公开（公告）日：2004-01-14