1,3,5-trimethyl-4-pyridinone | 2683-34-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1,3,5-trimethyl-4-pyridinone
• 英文别名: 1,3,5-Trimethyl-pyridon-4；1,3,5-trimethyl-1H-pyridin-4-one；1,3,5-Trimethylpyridin-4-one
• CAS: 2683-34-3
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: BTQRWIFEWAAETG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,3,5-trimethyl-4-pyridinone 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以18%的产率得到2,3-dihydro-1,3,5-trimethyl-4-pyridinone
  参考文献：
  名称：

  Hatton, Paul M.; Sternhell, Sever, Journal of Heterocyclic Chemistry, 1992, vol. 29, # 4, p. 935 - 946

  摘要：

  DOI：
• 作为产物：
  描述：

  4-chloro-1,3,5-trimethylpyridine iodide 在 sodium hydroxide 作用下， 反应 2.5h， 以42%的产率得到1,3,5-trimethyl-4-pyridinone
  参考文献：
  名称：

  Hatton, Paul M.; Sternhell, Sever, Journal of Heterocyclic Chemistry, 1992, vol. 29, # 4, p. 935 - 946

  摘要：

  DOI：

文献信息

• COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS
  申请人：Alios Bio Pharma, Inc.

  公开号：US20150238498A1

  公开（公告）日：2015-08-27

  Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection with one or more small molecule compounds. Examples of paramyxovirus infection include an infection caused by human respiratory syncytial virus (RSV).

  本文披露了一些新的抗病毒化合物，以及包含一种或多种抗病毒化合物的药物组合物和合成它们的方法。还披露了使用一种或多种小分子化合物改善和/或治疗副黏液病毒病毒感染的方法。副黏液病毒感染的例子包括由人类呼吸道合胞病毒(RSV)引起的感染。
• PROCESS FOR PRODUCING AROMATIC CARBOXYLIC ACID
  申请人：DAICEL CHEMICAL INDUSTRIES, LTD.

  公开号：EP1734029A1

  公开（公告）日：2006-12-20

  A method of this invention produces an aromatic carboxylic acid, by oxidizing an aromatic compound B with oxygen in the presence of a catalytic nitrogen-containing cyclic compound A to thereby yield a corresponding aromatic carboxylic acid, the aromatic compound B having one or more hydrocarbon groups alone as substituents on its aromatic ring, and the catalytic nitrogen-containing cyclic compound A having a skeleton represented by following Formula (i): wherein X represents oxygen atom or an -OR group, and wherein R represents hydrogen atom or a hydroxyl-protecting group, as a constitutive member of its ring. The method includes the step of carrying out a reaction at a concentration of the aromatic compound B in the reaction system of 3.0 percent by weight or less, while continuously feeding the catalytic nitrogen-containing cyclic compound A, the aromatic compound B, a reaction solvent, and oxygen to a reactor and continuously extracting a reaction mixture from the reactor. This method can produce aromatic carboxylic acids with industrially good productivity without the need for special reaction facilities and without undergoing many steps.

  本发明的一种生产芳香族羧酸的方法，是在催化含氮环状化合物 A 的存在下，用氧气氧化芳香族化合物 B，从而得到相应的芳香族羧酸，芳香族化合物 B 的芳香环上有一个或多个单独的烃基作为取代基，而催化含氮环状化合物 A 的骨架由下式(i)表示： 其中 X 代表氧原子或-OR 基团，以及 其中 R 代表氢原子或羟基保护基团，作为其环的构成成员。该方法包括以下步骤：在反应体系中芳香族化合物 B 的浓度为 3.0%（重量百分比）或更低时进行反应，同时将催化的含氮环状化合物 A、芳香族化合物 B、反应溶剂和氧气连续加入反应器中，并连续从反应器中提取反应混合物。这种方法不需要特殊的反应设备，也不需要经过许多步骤，就能生产出工业生产效率高的芳香族羧酸。
• Methods for producing aromatic carboxylic acids
  申请人：Hirai Naruhisa

  公开号：US20070191634A1

  公开（公告）日：2007-08-16

  A method of this invention produces an aromatic carboxylic acid, by oxidizing an aromatic compound B with oxygen in the presence of a catalytic nitrogen-containing cyclic compound A to thereby yield a corresponding aromatic carboxylic acid, the aromatic compound B having one or more hydrocarbon groups alone as substituents on its aromatic ring, and the catalytic nitrogen-containing cyclic compound A having a skeleton represented by following Formula (i): wherein X represents oxygen atom or an —OR group, and wherein R represents hydrogen atom or a hydroxyl-protecting group, as a constitutive member of its ring. The method includes the step of carrying out a reaction at a concentration of the aromatic compound B in the reaction system of 3.0 percent by weight or less, while continuously feeding the catalytic nitrogen-containing cyclic compound A, the aromatic compound B, a reaction solvent, and oxygen to a reactor and continuously extracting a reaction mixture from the reactor. This method can produce aromatic carboxylic acids with industrially good productivity without the need for special reaction facilities and without undergoing many steps.
• US7524986B2
  申请人：——

  公开号：US7524986B2

  公开（公告）日：2009-04-28