6,7-dihydroxy-2-oxo-2H-1-benzopyran-3-carbonyl chloride | 84738-36-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 6,7-dihydroxy-2-oxo-2H-1-benzopyran-3-carbonyl chloride
• 英文别名: 6,7-Dihydroxychromone-3-carbonyl chloride；6,7-Dihydroxychromone-3-carboxylic chloride；6,7-dihydroxychromon-3-carbonyl chloride；6,7-dihydroxy-2-oxochromene-3-carbonyl chloride
• CAS: 84738-36-3
• 化学式: C₁₀H₅ClO₅
• 分子量: 240.6
• InChiKey: HVWIYRWMOQAIIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6,7-二羟基香豆素-3-羧酸 在 氯化亚砜 作用下， 以 二氯甲烷 、 苯 为溶剂， 生成 6,7-dihydroxy-2-oxo-2H-1-benzopyran-3-carbonyl chloride
  参考文献：
  名称：

  7-.alpha.-methoxycephalosporin derivatives, and antibacterial drugs

  摘要：

  小说7.alpha.-甲氧基头孢菌素衍生物，其药学上可接受的盐，其制备过程以及涉及该衍生物或盐的抗菌药物。该衍生物或盐对革兰氏阳性菌和革兰氏阴性菌有效。

  公开号：

  US04344944A1

文献信息

• Cephalosporin compounds and antibacterial drugs containing the same
  申请人：Eisai Co., Ltd.

  公开号：US04285941A1

  公开（公告）日：1981-08-25

  Novel cephalosporin compounds of the general formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted nitrogen-containing heterocyclic-thio group, R.sub.2 represents hydrogen or hydroxy, and R.sub.3, R.sub.4 and R.sub.5 each represents hydrogen, hydroxy or acyloxy, and their salts, and processes for the preparation thereof. The novel compounds and their salts have antibacterial activity.

  一种一般公式为：##STR1## 的新头孢菌素化合物，其中R.sub.1代表取代或未取代的含氮杂环硫基团，R.sub.2代表氢或羟基，R.sub.3、R.sub.4和R.sub.5分别代表氢、羟基或酰氧基，以及它们的盐，并且其制备方法。这些新化合物及其盐具有抗菌活性。
• Cephalosporin derivatives, and antibacterial drugs containing the
  申请人：Eisai Co., Ltd.

  公开号：US04285939A1

  公开（公告）日：1981-08-25

  New cephalosporin derivatives represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents hydroxy, acyloxy, and hydrogen provided that two or three of R.sub.1, R.sub.2, and R.sub.3 are not hydrogen at the same time, and their salts, and processes for the preparation thereof. The cephalosporin derivatives of the present invention are useful as antibacterial drugs.

  新的头孢菌素衍生物的一般式表示为：##STR1## 其中R.sub.1，R.sub.2和R.sub.3分别表示羟基，酰氧基和氢，条件是R.sub.1，R.sub.2和R.sub.3中的两个或三个同时不是氢，并且它们的盐以及制备它们的过程。本发明的头孢菌素衍生物可用作抗菌药物。
• Cephalosporin compounds
  申请人：Eisai Co., Ltd.

  公开号：US04468394A1

  公开（公告）日：1984-08-28

  A compound represented by the formula: ##STR1## wherein R.sub.1 is hydrogen or methoxy; R.sub.2 is hydrogen or hydroxy; R is ##STR2## wherein R.sub.3 and R.sub.4 are hydroxy or acyloxy, Y is oxygen, sulfur or >N-R.sub.5 wherein R.sub.5 is hydrogen or lower alkyl, and Z is sulfur or >N-R.sub.5 wherein R.sub.5 has the same meanings as defined above; and X is ##STR3## wherein R.sub.6 is acyloxy or nitrogen-containing heterocyclicthio which may have substituent(s), a pharmaceutically accpetable salt thereof, and a carboxylic ester thereof. This compound has improved antibacterial activity against Kleb. pneumoniae and Pseud. aeruginosa.

  一种化合物的化学式为：##STR1##其中R.sub.1是氢或甲氧基；R.sub.2是氢或羟基；R是##STR2##其中R.sub.3和R.sub.4是羟基或酰氧基，Y是氧，硫或>N-R.sub.5，其中R.sub.5是氢或较低的烷基，Z是硫或>N-R.sub.5，其中R.sub.5具有上述定义的相同含义；X是##STR3##其中R.sub.6是酰氧基或含氮杂环硫基，可以具有取代基，其药学上可接受的盐和羧酸酯。该化合物对Kleb. pneumoniae和Pseud. aeruginosa具有改善的抗菌活性。
• Cephalosporin derivatives, and antibacterial drugs comprising said
  申请人：Eisai Co., Ltd.

  公开号：US04285940A1

  公开（公告）日：1981-08-25

  New cephalosporin derivatives having the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents hydroxy or acyloxy and their salts, and processes for the production thereof. The cephalosporin derivatives of the present invention are useful as antibacterial drugs.

  新的头孢菌素衍生物具有以下一般式：##STR1## 其中R.sub.1和R.sub.2分别代表羟基或酰氧基及其盐，并提供其生产方法。本发明的头孢菌素衍生物可用作抗菌药物。
• N-(substituted chromone-3-carbonyl)-phenylglycine derivatives
  申请人：Eisai Co., Ltd.

  公开号：EP0054578A1

  公开（公告）日：1982-06-30

  N-(Substituted chromone-3-carbonyl) phenylglycine derivatives represented by the formula in which R, represents a hydrogen atom, and each R, represents a hydrogen atom, an alkoxycarbonyl group or a chlorine-substituted carbonyl group, are useful intermediates for cephem compounds which are excellent as antibacterial agents.

  N-（取代的色酮-3-羰基）苯基甘氨酸衍生物由式（其中 R 代表氢原子，每个 R 代表氢原子、烷氧羰基或氯取代的羰基）表示，是具有优异抗菌性能的头孢类化合物的有用中间体。