methoxy-[2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-ylamino]-acetic acid ethyl ester | 478036-07-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methoxy-[2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-ylamino]-acetic acid ethyl ester
• 英文别名: Ethyl 2-methoxy-2-[[2-methoxy-6-[2-methoxy-4-(trifluoromethoxy)phenyl]-5-methylpyridin-3-yl]amino]acetate
• CAS: 478036-07-6
• 化学式: C₂₀H₂₃F₃N₂O₆
• 分子量: 444.408
• InChiKey: HPHGJXZPZRZDHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  88.1
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  乙醛酸乙酯 、 2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-ylamine 以 甲醇 为溶剂， 生成 methoxy-[2-methoxy-6-(2-methoxy-4-trifluoromethoxy-phenyl)-5-methyl-pyridin-3-ylamino]-acetic acid ethyl ester
  参考文献：
  名称：

  2,5-diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylpyrimidines

  摘要：

  提供作为CRF 1受体选择性调节剂的Diarylpyrazine、diarylpyridine和diarylpyrimidine化合物。这些化合物对治疗多种中枢神经系统和外周疾病特别有效，包括压力、焦虑、抑郁、心血管疾病和进食障碍。还提供了治疗这些疾病的方法以及包装的药物组合物。Formula I的化合物也可用作CRF受体的定位探针和CRF受体结合测定中的标准。给出了使用这些化合物进行受体定位研究的方法。

  公开号：

  US20030119844A1

文献信息

• 2,5-Diarylpyrazines, 2,5-diarylpyridines and 2,5-diarylprimidines
  申请人：Huang Jianhua

  公开号：US20050176721A1

  公开（公告）日：2005-08-11

  Diarylpyrazine, diarylpyridine, and diarylpyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of Formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

  提供了作为CRF 1 受体选择性调节剂的二芳基吡嗪、二芳基吡啶和二芳基嘧啶化合物。这些化合物在治疗许多中枢神经系统和周围疾病，特别是压力、焦虑、抑郁、心血管疾病和进食障碍方面具有用途。还提供了治疗这些疾病的方法以及包装的制药组合物。公式 I 的化合物也可用作CRF受体定位的探针，以及CRF受体结合测定中的标准。给出了使用这些化合物进行受体定位研究的方法。
• 2,5-DIARYLPYRAZINES, 2,5-DIARYLPYRIDINES AND 2,5-DIARYLPYRIMIDINES AS CRF1 RECEPTOR MODULATORS
  申请人：Neurogen Corporation

  公开号：EP1399428A1

  公开（公告）日：2004-03-24
• US6887875B2
  申请人：——

  公开号：US6887875B2

  公开（公告）日：2005-05-03
• [EN] 2,5-DIARYLPYRAZINES, 2,5-DIARYLPYRIDINES AND 2,5-DIARYLPYRIMIDINES AS CRF1 RECEPTOR MODULATORS<br/>[FR] 2,5-DIARYLPYRAZINES, 2,5-DIARYLPYRIDINES ET 2,5-DIARYLPYRIMIDINES UTILISES COMME MODULATEURS DE RECEPTEURS CRF1
  申请人：NEUROGEN CORP

  公开号：WO2002100838A1

  公开（公告）日：2002-12-19

  Diarylpyrazine, diarylpyridine, and diarylpyrimidine compounds that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of formula I are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.
• [EN] PHARMACEUTICAL COMPOSITIONS, AZO-HETEROCYCLIC COMPOUNDS AND METHOD FOR THE PRODUCTION AND USE THEREOF<br/>[FR] COMPOSITIONS PHARMACEUTIQUES, COMPOSES AZO-HETEROCYCLIQUES ET PROCEDES DE FABRICATION ET D'UTILISATION CORRESPONDANTS
  申请人：CHEMICAL DIVERSITY RES INST LT

  公开号：WO2005018531A2

  公开（公告）日：2005-03-03

  The inventive pharmaceutical composition exhibits an inhibiting activity with respect to serine proteinase (Kaspaz) and comprises an active substance embodied in the form of a pharmaceutically acceptable quantity of an azo-heterocyclic compound of general formula 1, 2 and 3 or the salts thereof with pharmacologically acceptable acid, hydrate one N-oxide.